{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:03:04Z","timestamp":1788991384716,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"unspecified","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Karolinska Institutet Research Foundation","award":["2018-01558"],"award-info":[{"award-number":["2018-01558"]}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["190043"],"award-info":[{"award-number":["190043"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The substantial differences in socioeconomic and lifestyle exposures between urban and rural areas in China may lead to urban\u2013rural disparity in cancer risk. This study aimed to assess the urban\u2013rural disparity in cancer incidence in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from 36 regional cancer registries in China in 2008\u20132012, we compared the age-standardised incidence rates of cancer by sex and anatomic site between rural and urban areas. We calculated the rate difference and rate ratio comparing rates in rural versus urban areas by sex and cancer type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence rate of all cancers in women was slightly lower in rural areas than in urban areas, but the total cancer rate in men was higher in rural areas than in urban areas. The incidence rates in women were higher in rural areas than in urban areas for cancers of the oesophagus, stomach, and liver and biliary passages, but lower for cancers of thyroid and breast. Men residing in rural areas had higher incidence rates for cancers of the oesophagus, stomach, and liver and biliary passages, but lower rates for prostate cancer, lip, oral cavity and pharynx cancer, and colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest substantial urban\u2013rural disparity in cancer incidence in China, which varies across cancer types and the sexes. Cancer prevention strategies should be tailored for common cancers in rural and urban areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-042762","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T11:37:09Z","timestamp":1619782629000},"page":"e042762","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Urban\u2013rural disparity in cancer incidence in China, 2008\u20132012: a cross-sectional analysis of data from 36 cancer registers"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-5627","authenticated-orcid":false,"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Hua","family":"Xie","sequence":"additional","affiliation":[{"name":"Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"2025120600022216000_11.4.e042762.1","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1016\/S2214-109X(18)30488-1","article-title":"Disparities by province, age, and sex in site-specific cancer burden attributable to 23 potentially modifiable risk factors in China: a comparative risk assessment","volume":"7","author":"Chen","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2025120600022216000_11.4.e042762.2","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/ijc.30825","article-title":"Cancer incidence and mortality: a cohort study in China, 2008-2013","volume":"141","author":"Pan","year":"2017","journal-title":"Int J Cancer"},{"key":"2025120600022216000_11.4.e042762.3","first-page":"19","article-title":"Esophageal cancer incidence and mortality in China, 2009","volume":"5","author":"Chen","year":"2013","journal-title":"J Thorac Dis"},{"key":"2025120600022216000_11.4.e042762.4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/1759-7714.12322","article-title":"Esophageal cancer statistics in China, 2011: estimates based on 177 cancer registries","volume":"7","author":"Zeng","year":"2016","journal-title":"Thorac Cancer"},{"key":"2025120600022216000_11.4.e042762.5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.21147\/j.issn.1000-9604.2018.03.01","article-title":"Incidence and mortality of stomach cancer in China, 2014","volume":"30","author":"Yang","year":"2018","journal-title":"Chin J Cancer Res"},{"key":"2025120600022216000_11.4.e042762.6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/1074286","article-title":"Analysis of mortality and survival rate of liver cancer in Zhejiang Province in China: a general population-based study","volume":"2019","author":"Fei","year":"2019","journal-title":"Can J Gastroenterol Hepatol"},{"key":"2025120600022216000_11.4.e042762.7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/1759-7714.12575","article-title":"Urban rural disparity in female breast cancer incidence rate in China and the increasing trend in parallel with socioeconomic development and urbanization in a rural setting","volume":"9","author":"Wen","year":"2018","journal-title":"Thorac Cancer"},{"key":"2025120600022216000_11.4.e042762.8","first-page":"663","article-title":"[Analysis of incidence and mortality of thyroid cancer in China, 2010]","volume":"48","author":"Yang","year":"2014","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"2025120600022216000_11.4.e042762.9","unstructured":"CI5 XI - Home, 2020. 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