{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:43:44Z","timestamp":1784169824633,"version":"3.55.0"},"reference-count":39,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"unspecified","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV20\/00923"],"award-info":[{"award-number":["COV20\/00923"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,2,12]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and preliminary results as recruitment is still open.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Three subcohorts can be identified at recruitment. Subcohort 1 includes women giving birth between 23 March and 25 May 2020; they have been retrospectively recruited and could have been exposed to COVID-19 only in their third trimester of pregnancy. Subcohort 2 includes women giving birth from 26 May 2020 on; they are being prospectively recruited and could have been exposed to COVID-19 in both their second and third trimesters of pregnancy. Subcohort 3 includes women in their 12 week of pregnancy prospectively recruited from 26 May 2020 on; they could have been exposed to COVID-19 anytime in their pregnancy. All women are being tested for SARS-CoV-2 infection using both RT-PCR for RNA detection and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies using immunochemoluminiscency tests; if the mother is tested positive for SARS-CoV-2 RNA, a nasopharyngeal swab is also obtained from the child for RT-PCR analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings to date<\/jats:title><jats:p>As of 22 October, 1167 women have been recruited (266, 354 and 547 for subcohorts 1, 2 and 3, respectively). Fourteen women tested positive to SARS-CoV-2 RNA by the day of delivery. All 14 children born from these women tested negative for SARS-CoV-2 RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Future plans<\/jats:title><jats:p>Children from women included in subcohort 3 are expected to be recruited by the end of 2020. Children will be followed-up for 1\u2009year in order to ascertain the effect that COVID-19 on their development.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2020-044224","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T16:18:11Z","timestamp":1614356291000},"page":"e044224","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8569-861X","authenticated-orcid":false,"given":"Javier","family":"Llorca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Lechosa-Mu\u00f1iz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Gortazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Fern\u00e1ndez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Jubete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J","family":"Cabero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"2024101905114315000_11.2.e044224.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"2024101905114315000_11.2.e044224.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"2024101905114315000_11.2.e044224.3","doi-asserted-by":"publisher","DOI":"10.3390\/v12020194"},{"key":"2024101905114315000_11.2.e044224.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.03008.x"},{"key":"2024101905114315000_11.2.e044224.5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/aogs.13921","article-title":"Clinical course of coronavirus disease-2019 in pregnancy","volume":"99","author":"Pereira","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2024101905114315000_11.2.e044224.6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0140-6736(20)31714-1","article-title":"Seroprevalence and presentation of SARS-CoV-2 in pregnancy","volume":"396","author":"Crovetto","year":"2020","journal-title":"Lancet"},{"key":"2024101905114315000_11.2.e044224.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.04.013"},{"key":"2024101905114315000_11.2.e044224.8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ajog.2020.03.021","article-title":"Coronavirus disease 2019 (COVID-19) pandemic and pregnancy","volume":"222","author":"Dashraath","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2024101905114315000_11.2.e044224.9","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13901"},{"key":"2024101905114315000_11.2.e044224.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2107"},{"key":"2024101905114315000_11.2.e044224.11","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6925a1"},{"key":"2024101905114315000_11.2.e044224.12","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/1471-0528.16403","article-title":"Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study","volume":"127","author":"Prabhu","year":"2020","journal-title":"BJOG"},{"key":"2024101905114315000_11.2.e044224.13","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13867"},{"key":"2024101905114315000_11.2.e044224.14","doi-asserted-by":"crossref","unstructured":"Hedermann G , Hedley PL , B\u00e6kvad-Hansen M , et al . 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