{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:41:30Z","timestamp":1790876490993,"version":"4.1.0"},"reference-count":39,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,6,15]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>There is a lack of evidence about the use of local anaesthetics (LAs) in patients with cardiovascular diseases (CVD) in dental procedures. Thus, this study evaluated the safety of using LA with vasoconstrictor to determine the risk of cardiovascular events in patients with CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We have searched in Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (via Ovid), EMBASE (via Ovid), Healthstar (via Ovid), CINAHL, Web of Science and ClinicalTrials.gov for randomised controlled trials (RCTs) up to January 2020. We have included RCTs involving adults with CVD within two groups: intervention group with LA with vasoconstrictor and control group with LA without vasoconstrictor. The primary outcomes assessed were death, mortality by a specific cause, stroke, acute myocardial infarction, hospitalisation, pain, bleeding and arrhythmias. The secondary outcomes were ST segment depression, anxiety, adverse effects and changes in haemodynamic parameters. The data were pooled using random effects meta-analyses and the confidence in the estimates was verified using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten RCTs (n=478 participants) were included. Most of them had a high risk of bias. There were more cases of pain and bleeding in groups without vasoconstrictor. Meta-analysis demonstrated a decrease in the systolic blood pressure with the use of LA with vasoconstrictor (standard mean difference \u22120.95, 95%\u2009CI \u22121.35 to \u22120.55) after procedure. Overall, for the other outcomes assessed there was no statistical difference. The quality of evidence was considered low according to the GRADE profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that the use of LA with vasoconstrictors (epinephrine in low doses) is safe in patients with some types of CVD. However, the low quality of evidence demonstrated that literature needs further studies in order to confirm these results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Protocol registration<\/jats:title>\n                    <jats:p>PROSPERO (CRD42016045421).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-044357","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T12:37:21Z","timestamp":1626352641000},"page":"e044357","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Local anaesthetics combined with vasoconstrictors in patients with cardiovascular disease undergoing dental procedures: systematic review and meta-analysis"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-528X","authenticated-orcid":false,"given":"Caio Chaves","family":"Guimaraes","sequence":"first","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic, Instituto de Pesquisas S\u00e3o Leopoldo Mandic, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3684-3275","authenticated-orcid":false,"given":"Luciane Cruz","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-1806","authenticated-orcid":false,"given":"Cristiane de C\u00e1ssia","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Cama","family":"Ramacciato","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Anesthesiology and Therapeutics, Faculdade S\u00e3o Leopoldo Mandic, Instituto de Pesquisas S\u00e3o Leopoldo Mandic, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-9075","authenticated-orcid":false,"given":"Marcus Tolentino","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universidade de Sorocaba, Sorocaba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy de Oliveira","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic, Instituto de Pesquisas S\u00e3o Leopoldo Mandic, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Karol","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Faculdade S\u00e3o Leopoldo Mandic, Instituto de Pesquisas S\u00e3o Leopoldo Mandic, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-7883","authenticated-orcid":false,"given":"Rog\u00e9rio Hel\u00e1dio Lopes","family":"Motta","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Anesthesiology and Therapeutics, Faculdade S\u00e3o Leopoldo Mandic, Instituto de Pesquisas S\u00e3o Leopoldo Mandic, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"2025121511155734000_11.7.e044357.1","unstructured":"World Health Organization . 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