{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:00:20Z","timestamp":1785333620722,"version":"3.55.0"},"reference-count":22,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key Research and Development Program project of Liaoning Province","award":["2019JH2\/10300013"],"award-info":[{"award-number":["2019JH2\/10300013"]}]},{"name":"Young and middle-aged scientific and technological talent support plan project, Shenyang city, China","award":["RC200437"],"award-info":[{"award-number":["RC200437"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,1,7]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The strategy for upper gastrointestinal cancer (UGC) screening has not yet been determined, especially in northeast China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The sample was from an ongoing prospective population-based cohort for cancer screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>This study belonged to the Chinese Urban Cancer Screening Program. The analysis was based on the recruitment of participants aged 40\u201374 in Northeast China from 2016 to 2017. Totally, 39\u2009369 eligible participants were recruited, 8772 were evaluated to be at high risk for UGC, 1957 underwent endoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>\n                      \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test and multifactor logistic regression model was performed to analyse influencing factors of participation rate. Receiver operating characteristic curve analysis was applied to evaluate the diagnostic power of the high-risk assessment. The Cox regression model was used to estimate hazard ratio (HR) for the potential value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The high-risk rate was 22.28% and the participation rate of endoscopy screening was 22.31%. Factors such as age at 45\u201359 years, female sex, high level of education, occupation for professional and technical personnel, former drinking, secondary smoking, less physical activity, history of trauma or mental depression, history of upper gastrointestinal system disease and family history of UGC were associated with increased participation in endoscopy screening (all the p&lt;0.05). There were five UGCs, 86 oesophageal precancerous lesions and 145 gastric precancerous lesions, and the detection rates were 0.26%, 4.39% and 7.41%, respectively. The detection rate for both oesophageal and gastric lesions increased with age and was higher for men than for women (all the p&lt;0.05). After a 3-year follow-up, 30 UGCs had been diagnosed and the high risk of UGC increased the mortality risk ratio (HR: 1.90, 95%\u2009confidence interval (CI) 1.41 to 2.56).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The participation rate and outcomes of UGC screening were promising in our study and will provide important reference for evaluating value of UGC screening in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-046134","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T12:31:02Z","timestamp":1644928262000},"page":"e046134","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Outcomes of upper gastrointestinal cancer screening in high-risk individuals: a population-based prospective study in Northeast China"],"prefix":"10.1136","volume":"12","author":[{"given":"Zhifu","family":"Yu","sequence":"first","affiliation":[{"name":"Liaoning Office for Cancer Control and Research, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zuo","sequence":"additional","affiliation":[{"name":"Liaoning Office for Cancer Control and Research, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yu","sequence":"additional","affiliation":[{"name":"Liaoning Office for Cancer Control and Research, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoulan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Chronic Non-Communicable Diseases, Heping District Center for Disease Control and Prevention, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chronic Non-Communicable Diseases, Dadong District Center for Disease Control and Prevention, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5224-7828","authenticated-orcid":false,"given":"Yunyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Liaoning Office for Cancer Control and Research, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"2025121400223439000_12.2.e046134.1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"2025121400223439000_12.2.e046134.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"2025121400223439000_12.2.e046134.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.10.098"},{"key":"2025121400223439000_12.2.e046134.4","doi-asserted-by":"crossref","unstructured":"Yang S , Wu S , Huang Y , et al . Screening for oesophageal cancer. Cochrane Database Syst Rev 2012;2.doi:10.1002\/14651858.CD007883.pub2","DOI":"10.1002\/14651858.CD007883.pub2"},{"key":"2025121400223439000_12.2.e046134.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.0423"},{"key":"2025121400223439000_12.2.e046134.6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/ajr.12064","article-title":"Reduction of gastric cancer mortality by endoscopic and radiographic screening in an isolated island: a retrospective cohort study","volume":"21","author":"Matsumoto","year":"2013","journal-title":"Aust J Rural Health"},{"key":"2025121400223439000_12.2.e046134.7","first-page":"725","article-title":"Overview of the National cancer screening programme and the cancer screening status in Korea","volume":"12","author":"Kim","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"2025121400223439000_12.2.e046134.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.128"},{"key":"2025121400223439000_12.2.e046134.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2014.11.009"},{"key":"2025121400223439000_12.2.e046134.10","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cgh.2018.03.014","article-title":"Model for identifying individuals at risk for esophageal adenocarcinoma","volume":"16","author":"Kunzmann","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025121400223439000_12.2.e046134.11","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux012"},{"key":"2025121400223439000_12.2.e046134.12","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70072-X"},{"key":"2025121400223439000_12.2.e046134.13","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1002\/cam4.2578","article-title":"Determinants of participation and detection rate of upper gastrointestinal cancer from population-based screening program in China","volume":"8","author":"Guo","year":"2019","journal-title":"Cancer Med"},{"key":"2025121400223439000_12.2.e046134.14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145097","article-title":"Massive endoscopic screening for esophageal and gastric cancers in a high-risk area of China","volume":"10","author":"Zheng","year":"2015","journal-title":"PLoS One"},{"key":"2025121400223439000_12.2.e046134.15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315520"},{"key":"2025121400223439000_12.2.e046134.16","first-page":"246","article-title":"Endoscopic screening for precancerous lesions of the esophagus in a high risk area in northern Iran","volume":"17","author":"Roshandel","year":"2014","journal-title":"Arch Iran Med"},{"key":"2025121400223439000_12.2.e046134.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050041"},{"key":"2025121400223439000_12.2.e046134.18","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bpg.2017.09.002","article-title":"Alcohol, smoking and risk of oesophago-gastric cancer","volume":"31","author":"Dong","year":"2017","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2025121400223439000_12.2.e046134.19","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.01249","article-title":"Sarcopenia and sarcopenic obesity as novel risk factors for gastric carcinogenesis: a health checkup cohort study","volume":"9","author":"Kim","year":"2019","journal-title":"Front Oncol"},{"key":"2025121400223439000_12.2.e046134.20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s10120-019-01033-8","article-title":"Diabetes mellitus is associated with an increased risk of gastric cancer: a cohort study","volume":"23","author":"Yang","year":"2020","journal-title":"Gastric Cancer"},{"key":"2025121400223439000_12.2.e046134.21","doi-asserted-by":"crossref","DOI":"10.1038\/srep35707","article-title":"Effectiveness evaluation of organized screening for esophageal cancer: a case-control study in Linzhou City, China","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"2025121400223439000_12.2.e046134.22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320200"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-046134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:22:44Z","timestamp":1765700564000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-046134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,15]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bmjopen-2020-046134"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-046134","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}