{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:02:08Z","timestamp":1787731328376,"version":"build-2784847793"},"reference-count":105,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019111","name":"Perron Institute for Neurological and Translational Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100019111","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Neurotrauma Research Program, Department of Health, State Government of Western Australia"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,4,19]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mild traumatic brain injury (mTBI) is a complex injury with heterogeneous physical, cognitive, emotional and functional outcomes. Many who sustain mTBI recover within 2\u2009weeks of injury; however, approximately 10%\u201320% of individuals experience mTBI symptoms beyond this \u2018typical\u2019 recovery timeframe, known as persistent post-concussion symptoms (PPCS). Despite increasing interest in PPCS, uncertainty remains regarding its prevalence in community-based populations and the extent to which poor recovery may be identified using early predictive markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>(1) Establish a research dataset of people who have experienced mTBI and document their recovery trajectories; (2) Evaluate a broad range of novel and established prognostic factors for inclusion in a predictive model for PPCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      The Concussion Recovery Study (\n                      <jats:italic>CREST<\/jats:italic>\n                      ) is a prospective, longitudinal observational cohort study conducted in Perth, Western Australia.\n                      <jats:italic>CREST<\/jats:italic>\n                      is recruiting adults aged 18\u201365 from medical and community-based settings with acute diagnosis of mTBI.\n                      <jats:italic>CREST<\/jats:italic>\n                      will create a state-wide research dataset of mTBI cases, with data being collected in two phases.\n                      <jats:italic>Phase I<\/jats:italic>\n                      collates data on demographics, medical background, lifestyle habits, nature of injury and acute mTBI symptomatology. In\n                      <jats:italic>Phase II<\/jats:italic>\n                      , participants undergo neuropsychological evaluation, exercise tolerance and vestibular\/ocular motor screening, MRI, quantitative electroencephalography and blood-based biomarker assessment. Follow-up is conducted\n                      <jats:italic>via<\/jats:italic>\n                      telephone interview at 1, 3, 6 and 12\u2009months after injury. Primary outcome measures are presence of PPCS and quality of life, as measured by the Post-Concussion Symptom Scale and the Quality of Life after Brain Injury questionnaires, respectively. Multivariate modelling will examine the prognostic value of promising factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Human Research Ethics Committees of Royal Perth Hospital (#RGS0000003024), Curtin University (HRE2019-0209), Ramsay Health Care (#2009) and St John of God Health Care (#1628) have approved this study protocol. Findings will be published in peer-reviewed journals and presented at scientific conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12619001226190.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-046460","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T13:21:40Z","timestamp":1620912100000},"page":"e046460","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Predicting outcome following mild traumatic brain injury: protocol for the longitudinal, prospective, observational Concussion Recovery (\n                    <i>CREST<\/i>\n                    ) cohort study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-5068","authenticated-orcid":false,"given":"Aleksandra 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