{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T22:08:21Z","timestamp":1781474901133,"version":"3.54.1"},"reference-count":29,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,11,26]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Both physical diseases such as infection and chronic pain and psychological disorders such as depression have been associated with herpes zoster (HZ) reactivation. However, the relationship between de Quervain syndrome (DQS), a painful tenosynovitis and HZ remains unclear. We investigated whether DQS increases the risk of HZ reactivation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective population-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>We used a subset of Taiwan\u2019s National Health Insurance Research Database, the Longitudinal Health Insurance Database which contains the registration files and original claims data of 1\u2009million randomly selected individuals from the National Health Insurance programme. The case group in this study comprised patients newly diagnosed with DQS between 2000 and 2012. Individuals without DQS comprised the control group. Cases and controls were 1:1 matched by age, sex and index year (defined as the year of DQS diagnosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Approximately 55% of the participants were \u226449 years. Most participants were women (77%). The incidence rate of HZ in the DQS group was 8.39 per 1000 person years. After adjustments for age, sex and comorbidities, patients with DQS had a 1.30 times higher risk of HZ reactivation than the control group. Stratification analysis revealed taht DQS increases the HZ risk in individuals \u226464 years, women, and patients without comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DQS is associated with an increased risk of HZ. Clinicians should be aware of this risk when dealing with patients with DQS, particularly in young adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-046891","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T12:13:56Z","timestamp":1640261636000},"page":"e046891","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Association between de Quervain syndrome and herpes zoster: a population-based cohort study"],"prefix":"10.1136","volume":"11","author":[{"given":"Chao-Yu","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, Taiwan"},{"name":"Department of Optometry \/ Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan"},{"name":"Center for General Education, National Taichung University of Science and Technology, Taichung, Taiwan"},{"name":"Department of General Education, National Chin-Yi University of Technology, Taichung, Taiwan"},{"name":"Rural Generalist Program Japan, GENEPRO, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Der-Shin","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-3676","authenticated-orcid":false,"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan"},{"name":"Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"2025121407420224000_11.12.e046891.1","doi-asserted-by":"crossref","unstructured":"Cooper C , Hunter\u2019s PK , Occupations Dof . Chapter 57: Repeated movements and repeated trauma affecting the musculoskeletal system. In: Edited by Baxter PJ, Aw Tc, Cockcroft a, et al. Tenth Edition. Hodder Arnold, 2010.","DOI":"10.1201\/b13467-76"},{"key":"2025121407420224000_11.12.e046891.2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/art.20535","article-title":"Prevalence and impact of musculoskeletal disorders of the upper limb in the general population","volume":"51","author":"Walker-Bone","year":"2004","journal-title":"Arthritis Care Res"},{"key":"2025121407420224000_11.12.e046891.3","unstructured":"Satteson E , Tannan SC , De Quervain Tenosynovitis . StatPearls [Internet]. 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