{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T17:02:59Z","timestamp":1765731779779,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"French Ministry of health","award":["9000 euros"],"award-info":[{"award-number":["9000 euros"]}]},{"name":"French Ministry of health","award":["COVID-19-20-0135"],"award-info":[{"award-number":["COVID-19-20-0135"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,4,24]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Healthcare workers are more likely to be infected by SARS-CoV-2. In order to assess the infectious risk associated with working in a hospital, we sought to estimate the proportion of healthcare professionals infected with SARS-CoV-2 by screening staff in a University Medical Center in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A hospital-wide screening campaign (comprising a serological test and a questionnaire) ran from 18 May to 26 July 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>The seroprevalence rate was analysed in a multivariate analysis according to sociodemographic variables (age, sex and profession), exposure to SARS-CoV-2 and symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4840 professionals were included, corresponding to 74.5% of the centre\u2019s staff. The seroprevalence rate (95% CI) was 9.7% (7.0% to 12.4%). Contact with a confirmed case of COVID-19 was significantly associated with seropositivity (OR (95% CI: 1.43, (1.15 to 1.78)). The seroprevalence rate was significantly higher among nursing assistants (17.6%) than among other healthcare professionals. The following symptoms were predictive of COVID-19: anosmia (OR (95% CI): 1.55, (1.49 to 1.62)), ageusia (1.21, (1.16 to 1.27)), fever (1.15, (1.12 to 1.18)), myalgia (1.03, (1.01 to 1.06)) and headache (1.03, (1.01 to 1.04)).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-047010","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T06:48:53Z","timestamp":1652770133000},"page":"e047010","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Hospital-wide SARS-CoV-2 antibody screening of 4840 staff members in a University Medical Center in France: a cross-sectional study"],"prefix":"10.1136","volume":"12","author":[{"given":"Marion","family":"Pierson-Marchandise","sequence":"first","affiliation":[{"name":"Department of Preventions, Risks, Medical Information and Epidemiology, CHU Amiens-Picardie, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Castelain","sequence":"additional","affiliation":[{"name":"Department of Virology, CHU Amiens-Picardie, Amiens, France"},{"name":"AGIR Research Unit, EA 4294, Amiens University, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Department of Preventions, Risks, Medical Information and Epidemiology, CHU Amiens-Picardie, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Brochot","sequence":"additional","affiliation":[{"name":"Department of Virology, CHU Amiens-Picardie, Amiens, France"},{"name":"AGIR Research Unit, EA 4294, Amiens University, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Schmit","sequence":"additional","affiliation":[{"name":"AGIR Research Unit, EA 4294, Amiens University, Amiens, France"},{"name":"Infectious Disease, CHU Amiens-Picardie, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momar","family":"Diouf","sequence":"additional","affiliation":[{"name":"Department of Statistics, University Hospital Centre Amiens-Picardie, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Ganry","sequence":"additional","affiliation":[{"name":"Department of Preventions, Risks, Medical Information and Epidemiology, CHU Amiens-Picardie, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-6707","authenticated-orcid":false,"given":"Maxime","family":"Gignon","sequence":"additional","affiliation":[{"name":"Department of Preventions, Risks, Medical Information and Epidemiology, CHU Amiens-Picardie, Amiens, France"},{"name":"CRP CPO, Amiens University, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"2025121408581703000_12.5.e047010.1","unstructured":"Sant\u00e9 Publique France . Recensement national des cas de COVID-19 chez les professionnels en \u00e9tablissements de sant\u00e9 [online]. Available: \/etudes-et-enquetes\/recensement-national-des-cas-de-covid-19-chez-les-professionnels-en-etablissements-de-sante [Accessed 20 Aug 2020]."},{"key":"2025121408581703000_12.5.e047010.2","unstructured":"World Health Organization . Population-based age-stratified seroepidemiological investigation protocol for COVID-19 virus infection, 17 March 2020 [online]. Report No.: WHO\/2019-nCoV\/Seroepidemiology\/2020.1, 2020. Available: https:\/\/apps.who.int\/iris\/handle\/10665\/331656 [Accessed 25 Feb 2022]."},{"key":"2025121408581703000_12.5.e047010.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104569"},{"key":"2025121408581703000_12.5.e047010.4","unstructured":"R Core Team . R: A language and environment for statistical computing. R foundation for statistical computing, Vienna, Austria [online], 2013. Available: https:\/\/www.r-project.org\/ [Accessed 9 Oct 2020]."},{"key":"2025121408581703000_12.5.e047010.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3517"},{"key":"2025121408581703000_12.5.e047010.6","unstructured":"Sant\u00e9 Publique France . COVID-19: point \u00e9pid\u00e9miologique du 9 juillet 2020 [online]. 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