{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:13:52Z","timestamp":1792696432967,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500306"],"award-info":[{"award-number":["81500306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["No.2018-I2M-1-001"],"award-info":[{"award-number":["No.2018-I2M-1-001"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,10,25]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Heart rate (HR) is a risk factor of mortality in many cardiovascular diseases but no clinical studies have focused on the association between HR and prognosis in patients with acute type A aortic dissection (ATAAD). This study aimed to evaluate the association between HR and long-term mortality and establish the criteria of HR in patients with ATAAD who underwent total aortic arch replacement combined with the frozen elephant trunk (TAR+FET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting and participants<\/jats:title>\n                    <jats:p>Retrospective cohort study that studied all consecutive patients with ATAAD who underwent TAR+FET in the Fuwai Hospital between 2009 and 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes and measures<\/jats:title>\n                    <jats:p>30-day postoperative, and estimated long-term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 707 patients with ATAAD who underwent TAR+FET were followed up for a median duration of 29 months (range, 5\u201377 months). In multivariate logistic analysis, HR (p&lt;0.001), age (p&lt;0.001), renal insufficiency (p=0.033), ejection fraction (p=0.005), cardiopulmonary bypass time (p&lt;0.001) and intraoperative blood loss (p=0.002) were significantly associated with 30-day postoperative and estimated long-term mortalities. A hinge point with a sharp increase in estimated long-term mortality was identified at 80 beats\/min (bpm), and compared with HR \u226480 bpm, HR &gt;80 bpm was associated with an almost threefold higher long-term mortality. HRs \u226460, 60\u201370, 70\u201380, 80\u201390, 90\u2013100, 100\u2013110 and &gt;110 bpm were associated with 3.9%, 4.0%, 3.8%, 7.2%, 9.5%, 10.1% and 14.4% yearly risks of death, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HR is a powerful predictor of long-term mortality in patients with ATAAD undergoing TAR+FET. HR &gt;80 bpm is independently associated with elevated long-term mortality for patients with ATAAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-047221","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T12:40:19Z","timestamp":1636634419000},"page":"e047221","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Predictive value of heart rate in patients with acute type A aortic dissection: a retrospective cohort study"],"prefix":"10.1136","volume":"11","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[{"name":"Anaesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College Fuwai Hospital, Xicheng District, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qipeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Pain Medicine, Peking University Third Hospital, Beijing, 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