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General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p&lt;0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p&lt;0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p&lt;0.001) showed a higher incidence in the central obesity group than in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2020-047230","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T16:35:58Z","timestamp":1621960558000},"page":"e047230","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-8108","authenticated-orcid":false,"given":"Jae-Sung","family":"Nam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Ho","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasan Almazouq","family":"Fahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Eun","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Gyun","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Heon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-3225","authenticated-orcid":false,"given":"Hyung-Ju","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"2021060309555870000_11.5.e047230.1"},{"key":"2021060309555870000_11.5.e047230.2","doi-asserted-by":"crossref","DOI":"10.1186\/s40733-015-0001-7","article-title":"Asthma and obesity: mechanisms and clinical implications","volume":"1","author":"Baffi","year":"2015","journal-title":"Asthma Res Pract"},{"key":"2021060309555870000_11.5.e047230.3","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00253","article-title":"Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity","volume":"9","author":"Costa","year":"2018","journal-title":"Front Physiol"},{"key":"2021060309555870000_11.5.e047230.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01004.x"},{"key":"2021060309555870000_11.5.e047230.5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/02770903.2017.1341522","article-title":"Effect of obesity on sinonasal disease in asthma","volume":"55","author":"Kanagalingam","year":"2018","journal-title":"J Asthma"},{"key":"2021060309555870000_11.5.e047230.6","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1002\/lary.24038","article-title":"Obesity and the risk of chronic rhinosinusitis, allergic rhinitis, and acute otitis media in school-age children","volume":"123","author":"Sidell","year":"2013","journal-title":"Laryngoscope"},{"key":"2021060309555870000_11.5.e047230.7","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0166-z"},{"key":"2021060309555870000_11.5.e047230.8","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3228"},{"key":"2021060309555870000_11.5.e047230.9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jaip.2014.09.022","article-title":"Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency","volume":"3","author":"Kashani","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2021060309555870000_11.5.e047230.10","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens","year":"2012","journal-title":"Rhinol Suppl"},{"key":"2021060309555870000_11.5.e047230.11","first-page":"145","article-title":"Eosinophilic nasal polyps are a rich source of eotaxin, eotaxin-2 and eotaxin-3","volume":"44","author":"Olze","year":"2006","journal-title":"Rhinology"},{"key":"2021060309555870000_11.5.e047230.12","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20191"},{"key":"2021060309555870000_11.5.e047230.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.018"},{"key":"2021060309555870000_11.5.e047230.14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis. 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