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Phase I determined key characteristics using an experienced-based codesign approach. Phase II evaluated the intervention using various measures and qualitative interviews in a mixed methods approach. Descriptive statistics were used to analyse measures data and framework analysis to analyse interviews.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A specialist cancer centre, UK.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>11 in phase I and 21 in phase II. Participants were in cancer treatment, recovery or palliative care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome<\/jats:title>\n                  <jats:p>Primary outcome: acceptability of the intervention, assessed by &gt;60% uptake of three sessions. Secondary outcomes: impact on psychological well-being using EQ-5D\/QLQ-C30, Profile of Mood Scale, Warwick and Edinburgh Mental Well-being Scale, Depression and Anxiety Severity Scale 21, Self-Compassion Scale, Acceptance and Action Questionnaire and a locally developed questionnaire to capture self-compassion post use. Physiological impact was assessed by change in heart rate (HR)\/HR variability and electrodermal activity (EDA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty participants (mean age=48.7 years; SD=16.87); 65% (n=13) completed three sessions. Mental well-being improved following each use and from baseline to after session 3 (VR 1\u2014z=2.846, p\u22640.01; VR 2\u2014z=2.501, p\u22640.01; VR 3\u2014z=2.492, p\u22640.01). There was statistically significant difference in mean scores for EDA at mid-session and post session compared with pre session (<jats:italic>F<\/jats:italic> (1.658, 4.973)=13.364, p&lt;0.05). There was statistically significant reduction in stress levels from baseline to post session 3. Participants found the intervention acceptable and highlighted areas for development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The intervention is acceptable and feasible and has shown positive effects on mental well-being\/stress in the oncology setting. Larger studies are needed to confirm findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-047626","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T12:15:38Z","timestamp":1644495338000},"page":"e047626","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["SafeSpace: what is the feasibility and acceptability of a codesigned virtual reality intervention, incorporating compassionate mind training, to support people undergoing cancer treatment in a clinical setting?"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-8215","authenticated-orcid":false,"given":"Geraldine","family":"O'Gara","sequence":"first","affiliation":[{"name":"Applied Health Research, Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, Portsmouth Hospitals NHS Trust, Portsmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Georgopoulou","sequence":"additional","affiliation":[{"name":"Applied Health Research, Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Anstiss","sequence":"additional","affiliation":[{"name":"Virtual Health Labs, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Macquarrie","sequence":"additional","affiliation":[{"name":"School of Computing and Mathematical Sciences, University of Greenwich, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Wheatstone","sequence":"additional","affiliation":[{"name":"Patient and Public Representative, Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbie","family":"Bellman","sequence":"additional","affiliation":[{"name":"Patient and Public Representative, Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Mental Health Research Unit, Derbyshire Healthcare NHS Foundation Trust, Derby, Derbyshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Steed","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Applied Health Research, Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"2025101810402704000_12.2.e047626.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605148"},{"key":"2025101810402704000_12.2.e047626.2","unstructured":"Macmillan . 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