{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:28:21Z","timestamp":1773865701423,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"unspecified","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"At the time of the study\u2019s onset, one of the authors (SO) was granted by the BMBF (German ministry for education and research) funded project \u2018ArthroMark\u2019 TP7.","award":["01EC1401A (funding code)"],"award-info":[{"award-number":["01EC1401A (funding code)"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,7,7]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the ability of fluorescence optical imaging (FOI) Xiralite in the discrimination between rheumatoid arthritis (RA) patients with and without need of rituximab (RTX) retherapy\u2014in comparison to clinical, laboratory and musculoskeletal ultrasound parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Patients with established RA were prospectively followed over 1 year by Disease Activity Score 28, patient\u2019s global disease activity (visual analogue scale 0\u2013100 mm), C reactive protein and erythrocyte sedimentation rate, ultrasound seven joint (US7) score and FOI in phases 1\u20133 and automatically generated PrimaVista mode (PVM) at baseline (before RTX) and after 3, 6 and 12 months. The need for RTX retherapy was decided by the treating rheumatologist\u2014blinded to imaging data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>31 patients (female 77.4%, mean age 60.1\u00b111.4, mean disease duration 14.9\u00b17.1 years) were included. Fourteen (45.2%) patients received RTX retherapy within 12 months. In the group with RTX retherapy, FOI in PVM mode was the only parameter that presented significant increase over time (\u03b2: 0.40, 95% CI: 0.08 to 0.71, p=0.013)\u2014compared with the group without retherapy. In the prediction model via ROC analysis, FOI in PVM reached the highest values of all imaging, clinical and laboratory parameters which was associated with retherapy over 1 year with an area under the curve (AUC) of 0.78 (OR: 0.84, 95% CI: 0.72 to 0.98, p=0.031). US7 GS synovitis score revealed similar association with an AUC of 0.73 (p=0.049).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>US7 GS synovitis score and FOI in PVM are able to discriminate between patients with and without need for RTX retherapy better than clinical and laboratory parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-047713","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T12:02:18Z","timestamp":1627992138000},"page":"e047713","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Is the fluorescence optical imaging (FOI) able to discriminate between rheumatoid arthritis patients with and without need of rituximab retherapy? A cohort study"],"prefix":"10.1136","volume":"11","author":[{"given":"Schahrasad Lisa","family":"Ridha Ali","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Glimm","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-1131","authenticated-orcid":false,"given":"Gerd R","family":"Burmester","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Hoff","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Schmittat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Backhaus","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Internal Medicine - Rheumatology and Clinical Immunology, Park-Klinik Wei\u00dfensee, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Klotsche","sequence":"additional","affiliation":[{"name":"Deutsches Rheumaforschungszentrum (DRFZ) Berlin, A Leibniz Institute, Berlin, Germany"},{"name":"Institute for Social Medicine, Epidemiology and Health Economics, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-4688","authenticated-orcid":false,"given":"Sarah","family":"Ohrndorf","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"2025121411070898000_11.8.e047713.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210715"},{"key":"2025121411070898000_11.8.e047713.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144998"},{"key":"2025121411070898000_11.8.e047713.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.22025"},{"key":"2025121411070898000_11.8.e047713.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390105"},{"key":"2025121411070898000_11.8.e047713.5","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22103"},{"key":"2025121411070898000_11.8.e047713.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.24646"},{"key":"2025121411070898000_11.8.e047713.7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201397"},{"key":"2025121411070898000_11.8.e047713.8","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/acr.21679","article-title":"Reliability of the novel 7-joint ultrasound score: results from an inter- and intraobserver study performed by rheumatologists","volume":"64","author":"Ohrndorf","year":"2012","journal-title":"Arthritis Care Res"},{"key":"2025121411070898000_11.8.e047713.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep139"},{"key":"2025121411070898000_11.8.e047713.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126953"},{"key":"2025121411070898000_11.8.e047713.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2010-148288"},{"key":"2025121411070898000_11.8.e047713.12","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1002\/art.38175","article-title":"Indocyanine green\u2013enhanced fluorescence optical imaging in patients with early and very early arthritis","volume":"66","author":"Werner","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2025121411070898000_11.8.e047713.13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"2025121411070898000_11.8.e047713.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2025121411070898000_11.8.e047713.15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148759"},{"key":"2025121411070898000_11.8.e047713.16","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-019-1989-5","article-title":"Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period","volume":"21","author":"Glimm","year":"2019","journal-title":"Arthritis Res Ther"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-047713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:07:13Z","timestamp":1765739233000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-047713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":16,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,3]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/bmjopen-2020-047713"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-047713","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}