{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:26:02Z","timestamp":1783441562840,"version":"3.54.6"},"reference-count":47,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["90700303"],"award-info":[{"award-number":["90700303"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["916.10159"],"award-info":[{"award-number":["916.10159"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["ERC-2014-CoG-64916"],"award-info":[{"award-number":["ERC-2014-CoG-64916"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,10,18]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the associations between neighbourhood deprivation and fetal growth, including growth in the first trimester, and adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The Netherlands, Rotterdam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>8617 live singleton births from the Generation R cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Exposition<\/jats:title>\n                    <jats:p>Living in a deprived neighbourhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Fetal growth trajectories of head circumference, weight and length.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Secondary outcomes measures<\/jats:title>\n                    <jats:p>Small-for-gestational age (SGA) and preterm birth (PTB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neighbourhood deprivation was not associated with first trimester growth. However, a higher neighbourhood status score (less deprivation) was associated with increased fetal growth in the second and third trimesters (eg, estimated fetal weight; adjusted regression coefficient 0.04, 95% CI 0.02 to 0.06). Less deprivation was also associated with decreased odds of SGA (adjusted OR 0.91, 95% CI 0.86 to 0.97, p=0.01) and PTB (adjusted OR 0.89, 95% CI 0.82 to 0.96, p=0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found an association between neighbourhood deprivation and fetal growth in the second and third trimester pregnancy, but not with first trimester growth. Less neighbourhood deprivation is associated with lower odds of adverse pregnancy outcomes. The associations remained after adjustment for individual-level risk factors. This supports the hypothesis that living in a deprived neighbourhood acts as an independent risk factor for fetal growth and adverse pregnancy outcomes, above and beyond individual risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-049075","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T11:58:00Z","timestamp":1637063880000},"page":"e049075","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Association between neighbourhood deprivation, fetal growth, small-for-gestational age and preterm birth: a population-based prospective cohort study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-9031","authenticated-orcid":false,"given":"Dionne V","family":"Gootjes","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, Rotterdam, The Netherlands"},{"name":"Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke G","family":"Posthumus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, Rotterdam, The Netherlands"},{"name":"Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W V","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands"},{"name":"Department of Paediatrics, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A P","family":"Steegers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, Rotterdam, The Netherlands"},{"name":"Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"2025121605215416000_11.11.e049075.1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1990"},{"key":"2025121605215416000_11.11.e049075.2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.55.2.111"},{"key":"2025121605215416000_11.11.e049075.3","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12430"},{"key":"2025121605215416000_11.11.e049075.4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/14767058.2012.735722","article-title":"Living in deprived urban districts increases perinatal health inequalities","volume":"26","author":"de Graaf","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025121605215416000_11.11.e049075.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9542-5"},{"key":"2025121605215416000_11.11.e049075.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.78"},{"key":"2025121605215416000_11.11.e049075.7","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0184"},{"key":"2025121605215416000_11.11.e049075.8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp025"},{"key":"2025121605215416000_11.11.e049075.9","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1177\/1933719117728801","article-title":"Maternal lifestyle impairs embryonic growth: the Rotterdam Periconception cohort","volume":"25","author":"Van Dijk","year":"2018","journal-title":"Reprod Sci"},{"key":"2025121605215416000_11.11.e049075.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.6998.171"},{"key":"2025121605215416000_11.11.e049075.11","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(90)90154-K"},{"key":"2025121605215416000_11.11.e049075.12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1017\/S2040174418000557","article-title":"Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review","volume":"10","author":"Vehmeijer","year":"2019","journal-title":"J Dev Orig Health Dis"},{"key":"2025121605215416000_11.11.e049075.13","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-016-0224-9"},{"key":"2025121605215416000_11.11.e049075.14","unstructured":"National Institute for Public Health and the Environment . 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