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Unfortunately, it has never been adapted to acute care despite compelling preclinical evidence showing that it is safe and effective for promoting neurological recovery when started within days after SCI. This article provides the protocol for a study that will determine the feasibility and explore potential benefits of early ABT in the form of in-bed leg cycling initiated within 48 hours after the end of spinal surgery for SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>PROMPT-SCI (protocol for rapid onset of mobilisation in patients with traumatic SCI) is a single-site single-arm proof-of-concept trial. Forty-five patients aged 18 years or older with a severe traumatic SCI (American Spinal Injury Association Impairment Scale grade A, B or C) from C0 to L2 undergoing spinal surgery within 48 hours of the injury will be included. Participants will receive daily 30\u2009min continuous sessions of in-bed leg cycling for 14 consecutive days, initiated within 48 hours of the end of spinal surgery. The feasibility outcomes are: (1) absence of serious adverse events associated with cycling, (2) completion of 1 full session within 48 hours of spinal surgery for 90% of participants and (3) completion of 11 sessions for 80% of participants. Patient outcomes 6 weeks and 6 months after the injury will be measured using neurofunctional assessments, quality of life questionnaires and inpatient length of stay. Feasibility and patient outcomes will be analysed with descriptive statistics. Patient outcomes will also be compared with a matched historical cohort that has not undergone in-bed cycling using McNemar and Student\u2019s t-tests for binary and continuous outcomes, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>PROMPT-SCI is approved by the Research Ethics Board of the CIUSSS NIM. Recruitment began in April 2021. Dissemination strategies include publications in scientific journals and presentations at conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04699474\">NCT04699474<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-049884","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T13:15:56Z","timestamp":1635772556000},"page":"e049884","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Protocol for rapid onset of mobilisation in patients with traumatic spinal cord injury (PROMPT-SCI) study: a single-arm proof-of-concept trial of early in-bed leg cycling following acute traumatic spinal cord injury"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct04699474","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-3893","authenticated-orcid":false,"given":"Jean-Marc","family":"Mac-Thiong","sequence":"first","affiliation":[{"name":"Department of Surgery, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Surgery, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreane","family":"Richard-Denis","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Research Centre, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Petit","sequence":"additional","affiliation":[{"name":"Research Centre, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Mechanical Engineering, \u00c9cole de technologie sup\u00e9rieure, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Barth\u00e9lemy","sequence":"additional","affiliation":[{"name":"Research Centre, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"School of Rehabilitation, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Dionne","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Research Centre, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S K","family":"Magnuson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"2025121411035331000_11.11.e049884.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0475-6"},{"key":"2025121411035331000_11.11.e049884.2","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2017.00517","article-title":"A systematic review of investigations into functional brain connectivity following spinal cord injury","volume":"11","author":"Athanasiou","year":"2017","journal-title":"Front Hum Neurosci"},{"key":"2025121411035331000_11.11.e049884.3","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.0233"},{"key":"2025121411035331000_11.11.e049884.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.02.009"},{"key":"2025121411035331000_11.11.e049884.5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh160"},{"key":"2025121411035331000_11.11.e049884.6","unstructured":"Weil MH . 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