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Even though functional consequences directly related to neurological impairment are well studied, post-stroke trajectories of functional health according to the International Classification of Functioning, Disability and Health are poorly understood. Particularly, no study investigated the relationship between post-stroke trajectories of activities of daily living (ADL) and self-rated health (SRH). However, such knowledge is of major importance to identify patients at risk of unfavourable courses. This prospective observational study aims to investigate trajectories of ADL and SRH, and their modifying factors in the course of the first year after stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>The study will consecutively enrol 300 patients admitted to a tertiary care hospital with acute ischaemic stroke or transient ischaemic attack (TIA; Age, Blood Pressure, Clinical Features, Duration of symptoms, Diabetes score \u22653). Patient inclusion is planned from May 2021 to September 2022. All participants will complete an interview assessing ADL, SRH, mental health, views on ageing and resilience-related concepts. Participants will be interviewed face-to-face 1\u20135 days post-stroke\/TIA in the hospital; and will be followed up after 6 weeks, 3 months, 6 months and 12 months via telephone. The 12-month follow-up will also include a neurological assessment. Primary endpoints are ADL operationalised by modified Rankin Scale scores and SRH. Secondary outcomes are further measures of ADL, functional health, physical activity, falls and fatigue. Views on ageing, social support, resilience-related concepts, affect, frailty, illness perceptions and loneliness will be examined as modifying factors. Analyses will investigate the bidirectional relationship between SRH and ADL using bivariate latent change score models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The study has been approved by the institutional review board of the University Medicine Greifswald (Ref. BB 237\/20). The results will be disseminated through scientific publications, conferences and media. Moreover, study results and potential implications will be discussed with patient representatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04704635\">NCT04704635<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2021-049944","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T17:03:21Z","timestamp":1624986201000},"page":"e049944","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between trajectories of post-stroke disability and self-rated health (NeuroAdapt): protocol for a prospective observational study"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct04704635","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-3252","authenticated-orcid":false,"given":"Sarah K","family":"Sch\u00e4fer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"von Sarnowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Bl\u00e4sing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Fl\u00f6el","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Wurm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"2024112411564474000_11.6.e049944.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309278"},{"key":"2024112411564474000_11.6.e049944.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308413"},{"key":"2024112411564474000_11.6.e049944.3","doi-asserted-by":"crossref","first-page":"e551","DOI":"10.1016\/S2468-2667(20)30190-0","article-title":"The burden of neurological diseases in Europe: an analysis for the global burden of disease study 2017","volume":"5","author":"Deuschl","year":"2020","journal-title":"Lancet Public Health"},{"key":"2024112411564474000_11.6.e049944.4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.658922"},{"key":"2024112411564474000_11.6.e049944.5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ea9f03"},{"key":"2024112411564474000_11.6.e049944.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.36"},{"key":"2024112411564474000_11.6.e049944.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"2024112411564474000_11.6.e049944.8","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jamaneurol.2017.2802","article-title":"Disability trajectories before and after stroke and myocardial infarction: the cardiovascular health study","volume":"74","author":"Dhamoon","year":"2017","journal-title":"JAMA Neurol"},{"key":"2024112411564474000_11.6.e049944.9","doi-asserted-by":"publisher","DOI":"10.1159\/000451034"},{"key":"2024112411564474000_11.6.e049944.10","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0467-5"},{"key":"2024112411564474000_11.6.e049944.11","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.038","article-title":"Trends in long-term mortality and morbidity in patients with no early complications after stroke and transient ischemic attack","volume":"26","author":"Edwards","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2024112411564474000_11.6.e049944.12","unstructured":"World Health Organization . 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