{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:54:56Z","timestamp":1793760896958,"version":"4.6.1"},"reference-count":43,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001921","name":"Public Health Research Programme","doi-asserted-by":"publisher","award":["11\/3002\/11"],"award-info":[{"award-number":["11\/3002\/11"]}],"id":[{"id":"10.13039\/501100001921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Measure effectiveness of family nurse partnership (FNP) home-visiting programme in reducing maltreatment and improving maternal health and child health, developmental and educational outcomes; explore effect moderators, mediators; describe costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Follow-up of BB:0\u20132 trial cohort (ISRCTN:23019866) up to age 7 years in England using record linkage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>1618 mothers aged 19 years or younger and their firstborn child(ren) recruited to BB:0\u20132 trial at less than 25 weeks gestation and not mandatorily withdrawn from trial or opted out. Intervention families were offered up to a maximum of 64 home visits by specially trained nurses from pregnancy until firstborn child was 2 years old, plus usually provided health and social care support. Comparator was usual care alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>Primary outcome: state-verified child-in-need status recorded at any time during follow-up. Secondary outcomes: referral to social services, child protection registration (plan), child-in-need categorisation, looked-after status, recorded injuries and ingestions any time during follow-up, early childcare and educational attendance, school readiness and attainment at key stage 1 (KS1), healthcare costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Match rates for 1547 eligible children (1517 singletons, 15 sets of twins) were 98.3% (NHS Digital) and 97.4% (National Pupil Database). There was no difference between study arms in the proportion of children being registered as in need (adjusted OR 0.98, 95% CI 0.74 to 1.31), or for any other measure of maltreatment. Children in the FNP arm were more likely to achieve a good level of development at reception age (school readiness) (adjusted OR 1.24, 95% CI 1.01 to 1.52). After adjusting for birth month, children in FNP arm were more likely to reach the expected standard in reading at KS1 (adjusted OR 1.26, 95% CI 1.02 to 1.57). We found no trial arm differences for resource use and costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FNP did not improve maltreatment or maternal outcomes. There was evidence of small advantages in school readiness and attainment at KS1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"ISRCTN23019866\">ISRCTN23019866<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2021-049960","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T17:15:13Z","timestamp":1644513313000},"page":"e049960","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Nurse-led home-visitation programme for first-time mothers in reducing maltreatment and improving child health and development (BB:2-6): longer-term outcomes from a randomised cohort using data linkage"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-036X","authenticated-orcid":false,"given":"Michael","family":"Robling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-9703","authenticated-orcid":false,"given":"Fiona V","family":"Lugg-Widger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Cannings-John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianna","family":"Angel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Channon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Fitzsimmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerenza","family":"Hood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Kenkre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenllian","family":"Moody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-4724","authenticated-orcid":false,"given":"Eleri","family":"Owen-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-7383","authenticated-orcid":false,"given":"Rhys D","family":"Pockett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6215-0870","authenticated-orcid":false,"given":"Jeremy","family":"Segrott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-2454","authenticated-orcid":false,"given":"Thomas","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"2022032701353424000_12.2.e049960.1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1542\/peds.78.1.65","article-title":"Preventing child abuse and neglect: a randomized trial of nurse home visitation","volume":"78","author":"Olds","year":"1986","journal-title":"Pediatrics"},{"key":"2022032701353424000_12.2.e049960.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550080054039"},{"key":"2022032701353424000_12.2.e049960.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.486"},{"key":"2022032701353424000_12.2.e049960.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550080047038"},{"key":"2022032701353424000_12.2.e049960.5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120182","article-title":"The effect of VoorZorg, the Dutch nurse-family partnership, on child maltreatment and development: a randomized controlled trial","volume":"10","author":"Mejdoubi","year":"2015","journal-title":"PLoS One"},{"key":"2022032701353424000_12.2.e049960.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00392-X"},{"key":"2022032701353424000_12.2.e049960.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015728"},{"key":"2022032701353424000_12.2.e049960.8","unstructured":"et al Robling M , Bekkers MJ , Bell K . 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