{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:05:39Z","timestamp":1790665539715,"version":"4.1.0"},"reference-count":40,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,5,7]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Mycoplasma genitalium<\/jats:italic>\n                      is a sexually transmitted infection (STI) pathogen. There have been no published studies concerning symptomatology, prevalence data, antibiotic resistance profiling or reports of co-infection with other STI in pregnant women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe these characteristics among pregnant women attending prenatal clinics in a large tertiary care centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Remnant genital samples collected from pregnant women between August 2018 and November 2019 were tested for\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      and\n                      <jats:italic>Trichomonas vaginalis<\/jats:italic>\n                      by the transcription-mediated amplification technique. Specimens with detectable\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      RNA were sequenced for 23S rRNA mutations associated with azithromycin resistance and\n                      <jats:italic>parC<\/jats:italic>\n                      and\n                      <jats:italic>gyrA<\/jats:italic>\n                      mutations associated with resistance to moxifloxacin. Demographic, obstetric and STI co-infection data were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 719 samples, 41 (5.7 %) were positive for\n                      <jats:italic>M. genitalium. M. genitalium<\/jats:italic>\n                      infection was associated with black race, Hispanic ethnicity and young age (p=0.003, p=0.008 and p=0.004, respectively).\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      infection was also associated with\n                      <jats:italic>T. vaginalis<\/jats:italic>\n                      co-infection and\n                      <jats:italic>Streptococcus agalactiae<\/jats:italic>\n                      (group B\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      ) colonisation (p\u22640.001 and p=0.002, respectively). Of the 41 positive samples, 26 (63.4%) underwent successful sequencing. Eight (30.8%) had 23S rRNA mutations related to azithromycin resistance. One of 26 (3.8%) positive samples with sequencing results had the gyrA gene mutation and 1 of 18 sequenced samples (5.6%) had the parC gene mutation associated with moxifloxacin resistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Prevalence rates of\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      in pregnant women was 5.7%.\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      infection disproportionately affects young black women co-infected with\n                      <jats:italic>T. vaginalis<\/jats:italic>\n                      . Pregnant women remain at risk for persistent infection with\n                      <jats:italic>M. genitalium<\/jats:italic>\n                      due to decreased azithromycin susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-050475","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T12:42:04Z","timestamp":1623674524000},"page":"e050475","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Retrospective analysis of infection and antimicrobial resistance patterns of\n                    <i>Mycoplasma genitalium<\/i>\n                    among pregnant women in the southwestern USA"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-7329","authenticated-orcid":false,"given":"Irene A","family":"Stafford","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Muldrew","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Berra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, 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