{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:51:30Z","timestamp":1791139890378,"version":"4.1.0"},"reference-count":57,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Franciscus Research Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100020406","name":"Dr. Falk Pharma","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100020406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research and Development Foundation of the Franciscus Gasthuis & Vlietland","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,12,10]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Biologics are effective for the treatment of inflammatory bowel disease (IBD). However, unwarranted variation in processes and outcomes has been reported in the treatment of IBD. A care pathway for the treatment of IBD has the potential to reduce practice variation and improve outcomes. This study aims to compare the effect of a uniform care pathway for the treatment of patients with IBD with biologics to the current situation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>IBD Value is a longitudinal multicentre non-randomised parallel cluster trial with a baseline period. The study takes place in eight centres in the Netherlands. The baseline period will run for 12 months, after which the care pathway will be implemented in 6 of the 8 participating hospitals during the implementation phase of 3 months. Hereafter, the effect of the care pathway will be assessed for 12 months. Total study period is 27 months. The primary outcome is the effect of the care pathway on disease control (IBD-Control questionnaire). Secondary outcomes are the effect of the care pathway on the other outcomes of the International Consortium of Health Outcomes Measurement IBD standard set, health-related generic quality of life, patient experiences and degree of variation; cost effectiveness of the care pathway; and the variation between hospitals in the aforementioned outcomes in the baseline period. Outcomes will be measured every 6\u2009months. The study started on 1 December 2020 and a minimum of 200 patients will be included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study was deemed not to be subject to Dutch law (WMO; Medical Research Involving Human Subjects Act) by the Medical Ethics Committee of the Erasmus MC, the Netherlands (registration number: MEC-2020\u2013075) and a waiver was provided. Results will be disseminated through peer-reviewed journals and presented at (inter)national conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NL8276.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-050539","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:50:17Z","timestamp":1641988217000},"page":"e050539","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Value-based care pathway for inflammatory bowel disease: a protocol for the multicentre longitudinal non-randomised parallel cluster IBD Value study with baseline period"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-596X","authenticated-orcid":false,"given":"Reinier Cornelis Anthonius","family":"van Linschoten","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Nieboer","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Birnie","sequence":"additional","affiliation":[{"name":"Department of Statistics and Education, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands"},{"name":"Department of Genetics, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menne","family":"Scherpenzeel","sequence":"additional","affiliation":[{"name":"Crohn & Colitis NL, Woerden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Evelyne","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Maasstad Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Albert Schweitzer Ziekenhuis, Dordrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Antonius","family":"Hazelzet","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Janneke","family":"van der Woude","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Louise","family":"West","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desir\u00e9e","family":"van Noord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"2025121219313828000_12.1.e050539.1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21815"},{"key":"2025121219313828000_12.1.e050539.2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.579"},{"key":"2025121219313828000_12.1.e050539.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03756.x"},{"key":"2025121219313828000_12.1.e050539.4","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20597"},{"key":"2025121219313828000_12.1.e050539.5","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"2025121219313828000_12.1.e050539.6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41575-018-0091-9","article-title":"Fatigue in IBD: epidemiology, pathophysiology and management","volume":"16","author":"Borren","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2025121219313828000_12.1.e050539.7","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx100"},{"key":"2025121219313828000_12.1.e050539.8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/apt.16445","article-title":"Systematic review: societal cost of illness of inflammatory bowel disease is increasing due to biologics and varies between continents","volume":"54","author":"van Linschoten","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121219313828000_12.1.e050539.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04303.x"},{"key":"2025121219313828000_12.1.e050539.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04466.x"},{"key":"2025121219313828000_12.1.e050539.11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.032"},{"key":"2025121219313828000_12.1.e050539.12","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31829936c2"},{"key":"2025121219313828000_12.1.e050539.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.08.029"},{"key":"2025121219313828000_12.1.e050539.14","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.cgh.2014.11.020","article-title":"Variation in treatment of patients with inflammatory bowel diseases at major referral centers in the United States","volume":"13","author":"Ananthakrishnan","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025121219313828000_12.1.e050539.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03445.x"},{"key":"2025121219313828000_12.1.e050539.16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/gastro\/gox005","article-title":"Variations in the medical treatment of inflammatory bowel disease among Gastroenterologists","volume":"6","author":"Singh","year":"2018","journal-title":"Gastroenterol Rep"},{"key":"2025121219313828000_12.1.e050539.17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1080\/14712598.2018.1537367","article-title":"Wide variation in the use and understanding of therapeutic drug monitoring for anti-TNF agents in inflammatory bowel disease: an inexact science?","volume":"18","author":"Samaan","year":"2018","journal-title":"Expert Opin Biol Ther"},{"key":"2025121219313828000_12.1.e050539.18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ygh2.331","article-title":"Barriers to anti\u2010TNFalpha prescription among Italian physicians managing inflammatory bowel disease","volume":"1","author":"Bezzio","year":"2019","journal-title":"GastroHep"},{"key":"2025121219313828000_12.1.e050539.19","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1097\/MIB.0000000000000933","article-title":"Variation in care of inflammatory bowel diseases patients in Crohn's and colitis foundation of America partners: role of gastroenterologist practice setting in disease outcomes and quality process measures","volume":"22","author":"Weaver","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"2025121219313828000_12.1.e050539.20","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv129"},{"key":"2025121219313828000_12.1.e050539.21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ajg.2016.524","article-title":"Improvements in the long-term outcome of Crohn's disease over the past two decades and the relation to changes in medical management: results from the population-based IBDSL cohort","volume":"112","author":"Jeuring","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"2025121219313828000_12.1.e050539.22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318440"},{"key":"2025121219313828000_12.1.e050539.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1011024"},{"key":"2025121219313828000_12.1.e050539.24","unstructured":"Lehtonen L , Wild C , Ricciardi W . Defining Value in \"Value-Based Healthcare\". In: Commission E , ed. Report of the Expert Panel on effective ways of investing in Health (EXPH). Luxembourg: European Commission, 2019."},{"key":"2025121219313828000_12.1.e050539.25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/ecco-jcc\/jjx161","article-title":"Developing a standard set of patient-centred outcomes for inflammatory bowel disease-an international, cross-disciplinary consensus","volume":"12","author":"Kim","year":"2018","journal-title":"J Crohns Colitis"},{"key":"2025121219313828000_12.1.e050539.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1511701"},{"key":"2025121219313828000_12.1.e050539.27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MEG.0000000000000782","article-title":"The impact of value-based healthcare for inflammatory bowel diseases on healthcare utilization: a pilot study","volume":"29","author":"van Deen","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121219313828000_12.1.e050539.28","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1093\/ibd\/izz066","article-title":"Improving the quality of inpatient ulcerative colitis management: promoting evidence-based practice and reducing care variation with an inpatient protocol","volume":"25","author":"Lewin","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"2025121219313828000_12.1.e050539.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.08.019"},{"key":"2025121219313828000_12.1.e050539.30","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzg057"},{"key":"2025121219313828000_12.1.e050539.31","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7586"},{"key":"2025121219313828000_12.1.e050539.32","unstructured":"IBD BeterKeten . IBD-zorg; gedeelde zorg 2020. Available: http:\/\/www.ibd-zorg.nl\/"},{"key":"2025121219313828000_12.1.e050539.33","unstructured":"Nederlandse Vereniging van Maag-Darm-Leverartsen . Handleiding Behandeling IBD - 2014-2015: Moderniseren van de Richtlijn IBD 2009: Nederlandse Vereniging van Maag-Darm-Leverartsen, 2015."},{"key":"2025121219313828000_12.1.e050539.34","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz180"},{"key":"2025121219313828000_12.1.e050539.35","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx009"},{"key":"2025121219313828000_12.1.e050539.36","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305600"},{"key":"2025121219313828000_12.1.e050539.37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/00365521.2020.1857430","article-title":"Cross-cultural translation and validation of the IBD-control questionnaire in the Netherlands: a patient-reported outcome measure in inflammatory bowel disease","volume":"56","author":"de Jong","year":"2021","journal-title":"Scand J Gastroenterol"},{"key":"2025121219313828000_12.1.e050539.38","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.197"},{"key":"2025121219313828000_12.1.e050539.39","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9496-9"},{"key":"2025121219313828000_12.1.e050539.40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2147\/PROM.S274015","article-title":"Patient experience monitor (Pem): the development of new short-form Picker experience questionnaires for hospital patients with a wide range of literacy levels","volume":"11","author":"Bastemeijer","year":"2020","journal-title":"Patient Relat Outcome Meas"},{"key":"2025121219313828000_12.1.e050539.41","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303376"},{"key":"2025121219313828000_12.1.e050539.42","unstructured":"Hakkaart-van Roijen L , van der Linden N , Bouwmans C . Richtlijn voor het uitvoeren van economische evaluaties in de gezondheidszorg. In: Authority DH , ed. Dutch healthcare authority, 2016: 1\u201373. https:\/\/www.zorginstituutnederland.nl\/over-ons\/publicaties\/publicatie\/2016\/02\/29\/richtlijn-voor-het-uitvoeren-van-economische-evaluaties-in-de-gezondheidszorg"},{"key":"2025121219313828000_12.1.e050539.43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jval.2016.01.003","article-title":"Dutch tariff for the five-level version of EQ-5D","volume":"19","author":"M Versteegh","year":"2016","journal-title":"Value Health"},{"key":"2025121219313828000_12.1.e050539.44","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"2025121219313828000_12.1.e050539.45","unstructured":"iMTA Productivity and Health Research Group . Handleiding iMTA medical cost questionnaire (iMCQ. Rotterdam: MTA, Erasmus Universiteit Rotterdam, 2018. www.imta.nl"},{"key":"2025121219313828000_12.1.e050539.46","unstructured":"UNESCO Institute for Statistics . International standard classification of education: ISCED 2011: UNESCO Institute for Statistics Montreal 2012."},{"key":"2025121219313828000_12.1.e050539.47","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"2025121219313828000_12.1.e050539.48","doi-asserted-by":"publisher","DOI":"10.1002\/art.10993"},{"key":"2025121219313828000_12.1.e050539.49","doi-asserted-by":"crossref","unstructured":"Mikocka-Walus A , Massuger W , Knowles SR . Quality of care in inflammatory bowel disease: actual health service experiences fall short of the Standards. J Intern Med 2019.doi:10.1111\/imj.14683","DOI":"10.1111\/imj.14683"},{"key":"2025121219313828000_12.1.e050539.50","doi-asserted-by":"crossref","unstructured":"Bodger K , Gledhill T , Driscoll R . PWE-054 independent validation of the ibd-control questionnaire: results from a large-scale electronic patient experience survey (ibd2020). BMJ Publishing Group, 2015.","DOI":"10.1136\/gutjnl-2015-309861.503"},{"key":"2025121219313828000_12.1.e050539.51","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200305000-00004"},{"key":"2025121219313828000_12.1.e050539.52","unstructured":"Hakkaart-van Roijen L , Van der Linden N , Bouwmans C . Kostenhandleiding. Methodologie van kostenonderzoek en referentieprijzen voor economische evaluaties in de gezondheidszorg. Zorginstituut Nederland, 2015."},{"key":"2025121219313828000_12.1.e050539.53","unstructured":"National Health Care Institute . Medicijnkosten 2019. Available: https:\/\/www.medicijnkosten.nl\/ [Accessed 18-06-2019]."},{"key":"2025121219313828000_12.1.e050539.54","unstructured":"Castor Electronic Data Capture [program]. Amsterdam 2016."},{"key":"2025121219313828000_12.1.e050539.55","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/j.gastro.2020.10.032","article-title":"Reduction in inflammatory bowel disease healthcare during the coronavirus disease 2019 pandemic: a nationwide retrospective cohort study","volume":"160","author":"Te Groen","year":"2021","journal-title":"Gastroenterology"},{"key":"2025121219313828000_12.1.e050539.56","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-182"},{"key":"2025121219313828000_12.1.e050539.57","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jval.2015.05.009","article-title":"The iMTA productivity cost questionnaire: a standardized instrument for measuring and Valuing health-related productivity losses","volume":"18","author":"Bouwmans","year":"2015","journal-title":"Value Health"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-050539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:31:48Z","timestamp":1765596708000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-050539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,12]]},"published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1136\/bmjopen-2021-050539"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-050539","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}