{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:27:13Z","timestamp":1793388433809,"version":"4.5.0"},"reference-count":13,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001652","name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Global Services Union","award":["VS\/2019\/0440"],"award-info":[{"award-number":["VS\/2019\/0440"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,9,23]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hairdressers constitute a major subgroup in the service sector. They are exposed to various substances hazardous for skin, airways or systemically. Accordingly, skin and other occupational diseases are common. The present systematic review will compile and appraise evidence regarding skin, systemic and airways toxicity of an indicative set of specific, important product ingredients. Additionally, evidence concerning hand eczema morbidity among hairdressers will be reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Systematic searches will be performed in two electronic literature databases (Medline, Web of Science\u2013Core Collection), the Cochrane register and two collections of toxicological dossiers (Scientific Committee on Consumer Safety of the European Commission and the MAK Commission of the German Research Council). Additional literature sources will be retrieved using hand search of reference lists of included studies and snowballing methods. We will include studies with all types of quantitative study designs, including results from in vitro and in vivo experiments, chemical analysis, epidemiological findings and clinical results. We will assess the risk of bias within studies amalgamating an abbreviated version of the Mixed Methods Appraisal Tool, basic Cochrane criteria and US Environmental Protection Agency assessment factors for scientific information. As we expect large heterogeneity in methods and outcomes, we will conduct a narrative synthesis of results instead of a meta-analysis, except where quantitative pooling is feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval and patient consent are not required as this is a systematic review based on published studies. The results of this study will be published in international peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42021238118<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-050612","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T15:12:25Z","timestamp":1666710745000},"page":"e050612","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Protocol for a systematic review on systemic and skin toxicity of important hazardous hair and nail cosmetic ingredients in hairdressers"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-3710","authenticated-orcid":false,"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Skin and Allergy, Gentofte Hospital, University of Copenhagen, Kobenhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Havmose","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Skin and Allergy, Gentofte Hospital, University of Copenhagen, Kobenhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Kezic","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health, Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam UMC Location AMC Coronel Institute for Work and Health, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-2020","authenticated-orcid":false,"given":"Henk F.","family":"van der Molen","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health, Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam UMC Location AMC Coronel Institute for Work and Health, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Macan","sequence":"additional","affiliation":[{"name":"Occupational Health and Environmental Medicine, Institute for Medical Research and Occupational Health, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u017deljka","family":"Babi\u0107","sequence":"additional","affiliation":[{"name":"Occupational Health and Environmental Medicine, Institute for Medical Research and Occupational Health, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajka","family":"Turk","sequence":"additional","affiliation":[{"name":"Occupational Health and Environmental Medicine, Institute for Medical Research and Occupational Health, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Symanzik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine, Health Theory and Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm), University of Osnabr\u00fcck, Osnabruck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swen M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine, Health Theory and Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm), University of Osnabr\u00fcck, Osnabruck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"2025121406523784000_11.12.e050612.1","first-page":"895","article-title":"Occupational exposures and obstructive lung disease: a case-control study in hairdressers","volume":"55","author":"Hashemi","year":"2010","journal-title":"Respir Care"},{"key":"2025121406523784000_11.12.e050612.2","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2011.582027"},{"key":"2025121406523784000_11.12.e050612.3","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102437"},{"key":"2025121406523784000_11.12.e050612.4","doi-asserted-by":"crossref","first-page":"27319","DOI":"10.1007\/s11356-019-05402-9","article-title":"Hairdressers are exposed to high concentrations of formaldehyde during the hair straightening procedure","volume":"26","author":"Pexe","year":"2019","journal-title":"Environ Sci Pollut Res Int"},{"key":"2025121406523784000_11.12.e050612.5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/alr.21834","article-title":"High occurrence of rhinitis symptoms in hairdressing apprentices","volume":"7","author":"Foss-Skiftesvik","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"key":"2025121406523784000_11.12.e050612.6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s10900-014-9983-y","article-title":"Occupational respiratory and musculoskeletal symptoms among Egyptian female Hairdressers","volume":"40","author":"Hassan","year":"2015","journal-title":"J Community Health"},{"key":"2025121406523784000_11.12.e050612.7","article-title":"Some aromatic amines, organic dyes, and related exposures","volume":"99","year":"2010","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2025121406523784000_11.12.e050612.8","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"2025121406523784000_11.12.e050612.9","unstructured":"Anon . CRD\u2019s Guidance for Undertaking Reviews in Health Care, 2009, 2009."},{"key":"2025121406523784000_11.12.e050612.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2009.01.009"},{"key":"2025121406523784000_11.12.e050612.11","unstructured":"Sterne JAC , Hern\u00e1n MA , McAlleenan A , et al . Chapter 25: Assessing risk of bias in a non-randomized study. In: Cochrane Handbook for Systematic Reviews of Interventions. 6.1. The Cochrane Collaboration 2020."},{"key":"2025121406523784000_11.12.e050612.12","unstructured":"Anon . A Summary of General Assessment Factors for Evaluating the Quality of Scientificand Technical Information - Prepared for the U.S. Environmental Protection Agency by Members of the Assessment Factors Workgroup, a Group of the EPA\u2019s Science Policy Council. US EPA, 2003."},{"key":"2025121406523784000_11.12.e050612.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39490.551019.BE"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-050612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T14:52:45Z","timestamp":1765723965000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-050612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":13,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,6]]},"published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1136\/bmjopen-2021-050612"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-050612","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}