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In this project, we aim to assess the efficacy of a web-based cognitive intervention targeting inhibitory control among problem gamblers, using a randomised controlled design. As impaired inhibitory control is involved in self-regulation difficulties in behavioural addictions, it represents a particularly relevant cognitive process to target for an online psychological intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This will be a single-blinded, randomised, comparative therapeutic web-based, controlled trial. Up to 200 non-treatment seeking adult problem gamblers with a Problem Gambling Severity Index-recent (PGSI-recent) score \u22655\u2009will be included. The intervention will be a computerised cognitive training program targeting inhibitory skills. The comparator, an active control, will be a computerised neutral sensorial program. Both programs will be carried out under similar conditions: biweekly online training for 6 weeks and optional telephone support will be offered to patients for debriefing. The main objective of the study is to assess the clinical efficacy of the online cognitive training program at 6 weeks, measured with the PGSI-recent. The secondary objectives are to assess the efficacy on the gambling behaviour assessed by the account-based gambling data, on the self-reported gambling practice, and on the inhibition performance at the neuropsychological level at 6, 14 and 52 weeks. We will also assess the acceptability of this program and the preferred level of guidance. Data analysis will be in intention-to-treat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This randomized controlled trial will be executed in compliance with the Helsinki Declaration, and was approved by the local ethics boards (Comit\u00e9 de Protection des Personnes) in October 2017. The findings will be published in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03673800\">NCT03673800<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-051641","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:18:51Z","timestamp":1638274731000},"page":"e051641","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Study protocol for an online randomised controlled trial among non-treatment seeking problem gamblers: training inhibition in online problem gambling (TRAIN-online) trial"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct03673800","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6533-1896","authenticated-orcid":false,"given":"Antoine","family":"Santiago","sequence":"first","affiliation":[{"name":"Addiction Team, CESP, Villejuif, \u00cele-de-France, France"},{"name":"Department of Addictology, N\u00eemes University Hospital, Nimes, Languedoc-Roussillon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Addiction Team, CESP, Villejuif, \u00cele-de-France, France"},{"name":"LIP\/PC2S, Universit\u00e9 Savoie Mont-Blanc, Chambery, Rh\u00f4ne-Alpes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Miranda","sequence":"additional","affiliation":[{"name":"Addiction Team, CESP, Villejuif, \u00cele-de-France, France"},{"name":"Adult Neurodeveloppment Center, Department of Psychiatry, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, AP-HP, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-4721","authenticated-orcid":false,"given":"C\u00e9dric","family":"Lemogne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Georges Pompidou European Hospital, AP-HP, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"LeStrat","sequence":"additional","affiliation":[{"name":"U1266, Institute of Psychiatry and Neurosciences of Paris, Paris, \u00cele-de-France, France"},{"name":"Department of Psychiatry, Louis-Mourier Hospital, AP-HP, Colombes, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"Benyamina","sequence":"additional","affiliation":[{"name":"Addiction Team, CESP, Villejuif, \u00cele-de-France, France"},{"name":"Department of Psychiatry and Addictology, Paul Brousse Hospital, AP-HP, Villejuif, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Perney","sequence":"additional","affiliation":[{"name":"Department of Addictology, N\u00eemes University Hospital, Nimes, Languedoc-Roussillon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Luquiens","sequence":"additional","affiliation":[{"name":"Addiction Team, CESP, Villejuif, \u00cele-de-France, France"},{"name":"Department of Addictology, N\u00eemes University Hospital, Nimes, Languedoc-Roussillon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"2025121513011105000_11.11.e051641.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1807"},{"key":"2025121513011105000_11.11.e051641.2","unstructured":"National council on problem gambling . 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