{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:16:56Z","timestamp":1765077416476,"version":"3.46.0"},"reference-count":35,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001311"],"award-info":[{"award-number":["82001311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,11,30]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Delayed cerebral ischaemia (DCI) caused by aneurysmal subarachnoid haemorrhage (aSAH) is the most frequent complication and typically contributes to poor neurological outcome or deterioration of patients\u2019 condition. Therefore, early accurate and effective prediction of DCI is urgently needed. This study aims to construct a dynamic nomogram for precisely calculating the risk of DCI in patients with aSAH. Internal validation of this tool is conducted using the training cohort, and independent external validation is completed by using other medical centre datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This study is a multicentre, retrospective, observational cohort study using data from patients with aSAH. The participants include all adult patients who received surgical treatment in neurosurgery of multiple medical centres from 1 September 2019 to 1 April 2021, including Renmin Hospital of Wuhan University, Huzhou Central Hospital, First Affiliated Hospital of Harbin Medical University, General Hospital of Northern Theatre Command and Affiliated Hospital of Panzhihua University. Clinical information is collected via the electronic medical record system, including demographic data, clinical state on admission and serum laboratory tests. Modified Fisher grade at admission, admission subarachnoid clot and cerebral oedema density, and residual postoperative subarachnoid clot density are determined using the electronic imagine record software. The primary outcome is DCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study protocol was reviewed and approved by the Medical Ethics Committee of Renmin Hospital of Wuhan University, which is the principal affiliation of this study (approval number: WDRM2021-K022). The other Ethics Committees, including Huzhou Central Hospital (approval number: 202108005\u201301), First Affiliated Hospital of Harbin Medical University (approval number: H202156), General Hospital of Northern Theater Command (approval number: Y2021060) and Affiliated Hospital of Panzhihua University (approval number: 202105002), also approved the protocol. The results of this research will be published in a peer-reviewed medical journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ChiCTR2100044448.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-051956","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T12:25:45Z","timestamp":1640262345000},"page":"e051956","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Development and external validation of a dynamic nomogram for delayed cerebral ischaemia after aneurysmal subarachnoid hemorrhage: a study protocol for a multicentre retrospective cohort study"],"prefix":"10.1136","volume":"11","author":[{"given":"Ping","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China"},{"name":"Department of Neurosurgery, Huzhou Central Hospital, Huzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzhou","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huzhou Central Hospital, Huzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shancai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huizhou Third People's Hospital, Huizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General Hospital of Northern Theatre Command, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangfan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Hospital of Panzhihua University, Panzhihua, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liguo","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-1030","authenticated-orcid":false,"given":"Qianxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"2025120618195339000_11.12.e051956.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30668-7"},{"key":"2025120618195339000_11.12.e051956.2","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000130"},{"key":"2025120618195339000_11.12.e051956.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.246"},{"key":"2025120618195339000_11.12.e051956.4","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199911000-00032"},{"key":"2025120618195339000_11.12.e051956.5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307711"},{"key":"2025120618195339000_11.12.e051956.6","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1447-46"},{"key":"2025120618195339000_11.12.e051956.7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105005","article-title":"Nomogram for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage in the Chinese population","volume":"29","author":"Liu","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2025120618195339000_11.12.e051956.8","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589275"},{"key":"2025120618195339000_11.12.e051956.9","doi-asserted-by":"crossref","unstructured":"Lee H , Perry JJ , English SW . 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