{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T17:23:17Z","timestamp":1765732997323,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Key Project of Jinhua City Science and Technology Research Plan","award":["2021-3-051"],"award-info":[{"award-number":["2021-3-051"]}]},{"name":"The Major Project of Jinhua City Science and Technology Research Plan","award":["2020-3-028"],"award-info":[{"award-number":["2020-3-028"]}]},{"name":"The General Project of Zhejiang Province Medical Science and Technology Plan","award":["2021KY1181"],"award-info":[{"award-number":["2021KY1181"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,3,25]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer seriously threatens human health worldwide. Cancer cachexia is one of the life-threatening consequences that occurs commonly in patients with cancer, and severely worsens patient survival, prognosis and quality of life. Previous studies have demonstrated that cancer cachexia is closely related to differential metabolites and metabolic pathways based on metabolomics analysis. This scoping review protocol, therefore, aims to provide the strategy for a formal scoping review that will summarise the differential metabolites and related metabolic pathways of cachexia in patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      The proposed scoping review will follow the Arksey and O\u2019Malley\u2019s methodological framework, Levac\n                      <jats:italic>et al<\/jats:italic>\n                      \u2019s recommendations for applying this framework, and Peters\u2019 enhancements of the framework. The key information from the selected studies will be extracted, including author, year of publication, cachexia definition, country\/origin, study design, setting, population and sample size, biological specimens, independent variables, independent variables\u2019 measure and statistical analysis. A summary of metabolites will be divided into several sections depending on the biological specimen. Differential metabolites will be compared between paired groups, and the number and names of related metabolic pathways will be counted and described. The reporting of this scoping review will be in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. This is a scoping review protocol and describes the planned review process and provides data examples extracted from a pilot study to confirm the feasibility of further investigation of the subject.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>An ethical approval is not required for this scoping review protocol, nor for the scoping review. The results of this scoping review will be disseminated through publication in a peer-reviewed journal, or presentation at a national or international conference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-052125","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T13:42:49Z","timestamp":1649770969000},"page":"e052125","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolomics studies on cachexia in patients with cancer: a scoping review protocol"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-1419","authenticated-orcid":false,"given":"Liang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Nursing, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"},{"name":"Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rufang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nursing, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxia","family":"Xu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-1056","authenticated-orcid":false,"given":"Jianfei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-5082","authenticated-orcid":false,"given":"Xianghong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Nursing, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"2025121409203148000_12.4.e052125.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025121409203148000_12.4.e052125.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"2025121409203148000_12.4.e052125.3","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJCA.2018.07.005"},{"key":"2025121409203148000_12.4.e052125.4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"2025121409203148000_12.4.e052125.5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MPA.0000000000001507","article-title":"Landscape of health-related quality of life in patients with early-stage pancreatic cancer receiving adjuvant or neoadjuvant chemotherapy: a systematic literature review","volume":"49","author":"Macarulla","year":"2020","journal-title":"Pancreas"},{"key":"2025121409203148000_12.4.e052125.6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00611"},{"key":"2025121409203148000_12.4.e052125.7","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1200\/JCO.20.01670","article-title":"Management of cancer cachexia: ASCO Guideline-Time to address the elephant in the room","volume":"38","author":"Huillard","year":"2020","journal-title":"J Clin Oncol"},{"key":"2025121409203148000_12.4.e052125.8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s13539-014-0164-8","article-title":"Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014","volume":"5","author":"von Haehling","year":"2014","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2025121409203148000_12.4.e052125.9","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01516-6"},{"key":"2025121409203148000_12.4.e052125.10","first-page":"1871","article-title":"A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer","volume":"26","author":"Vagnildhaug","year":"2018","journal-title":"Support Care Cancer"},{"key":"2025121409203148000_12.4.e052125.11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jcsm.12307","article-title":"Three cachexia phenotypes and the impact of fat-only loss on survival in Folfirinox therapy for pancreatic cancer","volume":"9","author":"Kays","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2025121409203148000_12.4.e052125.12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jcsm.12391","article-title":"Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? A prospective study","volume":"10","author":"da Rocha","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2025121409203148000_12.4.e052125.13","article-title":"Cachexia is associated with depression, anxiety and quality of life in cancer patients","author":"Sun","year":"2020","journal-title":"BMJ Support Palliat Care"},{"key":"2025121409203148000_12.4.e052125.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.018"},{"key":"2025121409203148000_12.4.e052125.15","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328352694f"},{"key":"2025121409203148000_12.4.e052125.16","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000065"},{"key":"2025121409203148000_12.4.e052125.17","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11091272","article-title":"Cancer takes a Toll on skeletal muscle by releasing heat shock Proteins-An emerging mechanism of cancer-induced cachexia","volume":"11","author":"Sin","year":"2019","journal-title":"Cancers"},{"key":"2025121409203148000_12.4.e052125.18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-016-1933-3","article-title":"Molecular mechanism of sarcopenia and cachexia: recent research advances","volume":"469","author":"Sakuma","year":"2017","journal-title":"Pflugers Arch"},{"key":"2025121409203148000_12.4.e052125.19","first-page":"181","article-title":"Omics and cachexia","volume":"20","author":"Twelkmeyer","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2025121409203148000_12.4.e052125.20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-47656-8_1","article-title":"Metabolomics: definitions and significance in systems biology","volume":"965","author":"Klassen","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"2025121409203148000_12.4.e052125.21","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101594","article-title":"Plasma metabolomics identifies lipid and amino acid markers of weight loss in patients with upper gastrointestinal cancer","volume":"11","author":"Miller","year":"2019","journal-title":"Cancers"},{"key":"2025121409203148000_12.4.e052125.22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcsm.12246","article-title":"Serum and urine metabolomics study reveals a distinct diagnostic model for cancer cachexia","volume":"9","author":"Yang","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2025121409203148000_12.4.e052125.23","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-008-0113-7"},{"key":"2025121409203148000_12.4.e052125.24","doi-asserted-by":"crossref","first-page":"92438","DOI":"10.1039\/C5RA19004E","article-title":"Integrated analysis of serum and intact muscle metabonomics identify metabolic profiles of cancer cachexia in a dynamic mouse model","volume":"5","author":"QuanJun","year":"2015","journal-title":"RSC Adv"},{"key":"2025121409203148000_12.4.e052125.25","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-016-0116-4"},{"key":"2025121409203148000_12.4.e052125.26","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"2025121409203148000_12.4.e052125.27","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-5-69"},{"key":"2025121409203148000_12.4.e052125.28","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000050"},{"key":"2025121409203148000_12.4.e052125.29","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"2025121409203148000_12.4.e052125.30","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-052125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T17:20:41Z","timestamp":1765732841000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-052125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,12]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bmjopen-2021-052125"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-052125","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}