{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:07:17Z","timestamp":1765699637659,"version":"3.48.0"},"reference-count":72,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fund for Science (Fondo para la Ciencia - FONCI) from the Ministry of Science, Technology and Environment of Cuba","award":["77\/2017"],"award-info":[{"award-number":["77\/2017"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,4,28]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>According to the World Alzheimer\u2019s Report 2019, around 50\u2009million people suffer from dementia, worldwide. Observational analysis revealed the existence of particular factors associated with the onset and progression of Alzheimer\u2019s disease (AD). There are no international homogeneous principles for the early detection and evaluation of memory impairment and possible AD. This work aimed at (1) determining the prevalence of possible AD in the elderly residing in urban and rural regions in Cuba and (2) identifying the main factors that could significantly influence on its occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The study includes four neuropsychological tests (Clock Drawing Test, Mini-Mental Status Examination, Short Portable Mental Status Questionnaire, Cognitive and Non-Cognitive Alzheimer\u2032s Disease Assessment Scale) and two scales (Clinical Dementia Rating and Global Deterioration Scale). Moreover, the protocol includes a survey with demographic and socioeconomic information, educational level, occupation, health, neuropsychological status of subjects, familial pathological history, comorbidities and lifestyles. The study will comprise a total of 1092 subjects aged \u226560, of both genders, and from every ethnic group settled in rural and urban areas. Primary outcomes: prevalence of possible AD. Secondary outcomes: correlation among risk and protective factors and AD, and comparison of the performance of neuropsychological tests and scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This research met the ethical codes of the Declaration of Helsinki. The Scientific Research Council of the Promoting Research Institute and the Ethics Committee of the Health Authorities approved the protocol. The proper written informed consent is also incorporated. The results of the survey will be published in scientific papers and shared with the Health Authorities of each municipality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-052704","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T11:06:13Z","timestamp":1667387173000},"page":"e052704","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of Alzheimer\u2032s disease in rural and urban areas in Cuba and factors influencing on its occurrence: epidemiological cross-sectional protocol"],"prefix":"10.1136","volume":"12","author":[{"given":"Yudisleidy","family":"L\u00f3pez Ricardo","sequence":"first","affiliation":[{"name":"Research Direction, Centro Nacional de Biopreparados, Bejucal, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Carmen","family":"Reyes Zamora","sequence":"additional","affiliation":[{"name":"Clinical trials, Research Direction, Centro Nacional de Biopreparados, Bejucal, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Perodin Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Research Direction, Centro de Neurociencias de Cuba, Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-2103","authenticated-orcid":false,"given":"Claudio","family":"Rodr\u00edguez Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Research Direction, Centro Nacional de Biopreparados, Bejucal, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2025121400043745000_12.11.e052704.1","unstructured":"WHO (World Health Organization) . World report on ageing and health; 2015. https:\/\/apps.who.int\/iris\/handle\/10665\/186463 [Accessed 22 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.2","unstructured":"ADI (Alzheimer\u2019s Disease International) . World Alzheimer report 2019 Attitudes to dementia; 2019. https:\/\/www.alzint.org\/u\/WorldAlzheimerReport2019.pdf [Accessed 22 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.3","unstructured":"Garc\u00e9s M , Crespo C , Finkel L . Study on neurodegenerative diseases in Spain and their economic and social impact Complutense University of Madrid; 2016. https:\/\/neuroalianza.org\/wp-content\/uploads\/Informe-NeuroAlianza-Completo-v-5-optimizado.pdf [Accessed 22 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.4","unstructured":"CELADE (Centro Latinoamericano y Caribe\u00f1o de Demograf\u00eda) . Advances in the implementation of the montevideo consensus on population and development on the subject of ageing, social protection and socioeconomic challenges. Bolet\u00edn de Envejecimiento Y Derechos de las Personas Mayores en Am\u00e9rica Latina Y El Caribe: CEPAL, 2019; 2019. https:\/\/www.cepal.org\/es\/enfoques\/avances-la-implementacion-consenso-montevideo-poblacion-desarrollo-tema-envejecimiento [Accessed 22 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.5","unstructured":"ADI\/BUPA . Dementia in the Americas: Current and future cost and prevalence of Alzheimer\u2019s disease and other dementias; 2013. https:\/\/www.alzint.org\/u\/dementia-in-the-americas-ENGLISH.pdf [Accessed 03 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.regg.2018.12.007","article-title":"[Prevalence of dementia in the elderly in Latin America: a systematic review]","volume":"54","author":"Zurique S\u00e1nchez","year":"2019","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"2025121400043745000_12.11.e052704.7","unstructured":"ONEI (Oficina Nacional de Estad\u00edstica e Informaci\u00f3n) . The aging of the population. Cuba and its territories January-December 2019, 2021. http:\/\/www.onei.gob.cu\/node\/13821"},{"key":"2025121400043745000_12.11.e052704.8","unstructured":"MINSAP (Ministerio de Salud P\u00fablica) . Health statistical Yearbook. Direcci\u00f3n de Registros M\u00e9dicos Y Estad\u00edsticas de Salud 2015; 2016. http:\/\/www.sld.cu\/anuncio\/2016\/10\/11\/anuario-estadistico-de-salud-2015 [Accessed 04 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.14283\/jpad.2019.7","article-title":"Factors associated with alzheimer's disease: an overview of reviews","volume":"6","author":"Rochoy","year":"2019","journal-title":"J Prev Alzheimers Dis"},{"key":"2025121400043745000_12.11.e052704.10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-publhealth-040218-043758","article-title":"Causes and patterns of dementia: an update in the era of redefining alzheimer's disease","volume":"40","author":"James","year":"2019","journal-title":"Annu Rev Public Health"},{"key":"2025121400043745000_12.11.e052704.11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/JAD-2009-1046","article-title":"Alzheimer's disease research: scientific productivity and impact of the top 100 investigators in the field","volume":"16","author":"Sorensen","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"2025121400043745000_12.11.e052704.12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3233\/JAD-161149","article-title":"Recent progress in alzheimer's disease research, part 2: genetics and epidemiology","volume":"57","author":"Robinson","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"2025121400043745000_12.11.e052704.13","first-page":"329","volume-title":"Protein aggregation and fibrillogenesis in cerebral and systemic amyloid disease. subcellular biochemistry","volume":"65","author":"De-Paula","year":"2012"},{"key":"2025121400043745000_12.11.e052704.14","doi-asserted-by":"crossref","unstructured":"Men\u00e9ndez-Gonz\u00e1lez M . Early Diagnosis and Risk of Conversion from Presymptomatic Stages. 2. In: Cham S , ed. Atlas of Biomarkers for Alzheimer\u2019s Disease. Switzerland: International Publishing, 2014: 1\u201315.","DOI":"10.1007\/978-3-319-07989-9_1"},{"key":"2025121400043745000_12.11.e052704.15","first-page":"515","article-title":"Taupathy in Alzheimer\u2019s disease","volume":"33","author":"De la Fuente-Rocha","year":"2017","journal-title":"Med Int M\u00e9x"},{"key":"2025121400043745000_12.11.e052704.16","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.00265","article-title":"Mechanisms of pathogenic tau and A\u03b2 protein spreading in Alzheimer's disease","volume":"12","author":"D'Errico","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"2025121400043745000_12.11.e052704.17","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"2025121400043745000_12.11.e052704.18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2458-14-643","article-title":"Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis","volume":"14","author":"Beydoun","year":"2014","journal-title":"BMC Public Health"},{"key":"2025121400043745000_12.11.e052704.19","first-page":"378","article-title":"Dementias and Alzheimer\u2019s disease in Latin America and the Caribbean","volume":"40","author":"Llibre Rodr\u00edguez","year":"2014","journal-title":"Rev Cub Salud P\u00fablica"},{"key":"2025121400043745000_12.11.e052704.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.07.152"},{"key":"2025121400043745000_12.11.e052704.21","first-page":"29","article-title":"Prevalence of dementia and Alzheimer\u2019s disease in a havana municipality: a community-based study among elderly residents","volume":"11","author":"JdJ","year":"2009","journal-title":"MEDICC Rev"},{"key":"2025121400043745000_12.11.e052704.22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.37757\/MR2011V13.N4.7","article-title":"Dementia and other chronic diseases in older adults in havana and Matanzas: the 10\/66 study in Cuba","volume":"13","author":"Llibre","year":"2011","journal-title":"MEDICC Rev"},{"key":"2025121400043745000_12.11.e052704.23","first-page":"59","article-title":"Cognitive status assessment of adult persons aged over 60 made in a health area from \"plaza de la revoluci\u00f3n\" teaching polyclinic","volume":"48","author":"Monteagudo","year":"2009","journal-title":"Rev Cubana Med"},{"key":"2025121400043745000_12.11.e052704.24","first-page":"315","article-title":"Genetic epidemiology of aging associated with Alzheimer\u2019s disease in patients from Santa Clara","volume":"15","author":"Mart\u00ednez","year":"2011","journal-title":"Medicentro"},{"key":"2025121400043745000_12.11.e052704.25","unstructured":"Lanyau Y . Nutritional status of the elderly and its relationship with mild cognitive impairment and Alzheimer-type dementia in havana. (doctoral thesis): Universidad de Ciencias M\u00e9dicas de la habana La Habana; 2017. http:\/\/tesis.sld.cu\/index.php?P=DownloadFile&Id=807 [Accessed 21 Feb 2021]."},{"key":"2025121400043745000_12.11.e052704.26","first-page":"21","article-title":"Dependence for doing advanced and technological activitiesas a predictor of neurocognitive disorders in older adults","volume":"36","author":"Quispe-Ram\u00edrez","year":"2020","journal-title":"Med Int M\u00e9x"},{"key":"2025121400043745000_12.11.e052704.27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.regg.2014.09.004","article-title":"[An exploratory study on the use of cognitive and neuropsychological assessessments in centres for the elderly in Galicia]","volume":"50","author":"Facal","year":"2015","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"2025121400043745000_12.11.e052704.28","first-page":"1356","article-title":"A new rating scale for Alzheimer\u2019s disease","volume":"14","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"2025121400043745000_12.11.e052704.29","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001001000009"},{"key":"2025121400043745000_12.11.e052704.30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.47102\/annals-acadmedsg.V45N7p273","article-title":"Psychometric properties of Alzheimer's disease assessment scale-cognitive subscale for mild cognitive impairment and mild Alzheimer's disease patients in an Asian context","volume":"45","author":"Zainal","year":"2016","journal-title":"Ann Acad Med Singap"},{"key":"2025121400043745000_12.11.e052704.31","first-page":"598","article-title":"ADAS-cog (Alzheimer's disease assessment scale-cognitive subscale)--validation of the slovak version","volume":"101","author":"Kolibas","year":"2000","journal-title":"Bratisl Lek Listy"},{"key":"2025121400043745000_12.11.e052704.32","first-page":"139","article-title":"The Alzheimer\u2019s disease evaluation scale in Argentina: instructions for its administration","volume":"24","author":"Allegri","year":"1999","journal-title":"Rev Neurol Arg"},{"key":"2025121400043745000_12.11.e052704.33","unstructured":"Romero SJ . Validation of the instrument \"Alzheimer's Disease Assessment Scale\" (ADAS) for populations with Alzheimer's Disease and Mild Cognitive Impairment in Colombia. (Master's Thesis): Facultad de Ciencias Humanas \u2013 Departamento de Psicolog\u00eda Universidad Nacional de Colombia; 2014. https:\/\/repositorio.unal.edu.co\/handle\/unal\/49493https:\/\/repositorio.unal.edu.co\/bitstream\/handle\/unal\/49493\/4458670.2014.pdf?sequence=1&isAllowed=y [Accessed 24 Jan 2021]."},{"key":"2025121400043745000_12.11.e052704.34","first-page":"69","article-title":"[Adaptation and normalization of the Alzheimer's disease assessment scale for Spain (Normacodem) (II)]","volume":"12","author":"Pe\u00f1a-Casanova","year":"1997","journal-title":"Neurologia"},{"key":"2025121400043745000_12.11.e052704.35","first-page":"64","article-title":"[Spanish adaptation of the Alzheimer's disease assessment scale (ADAS)]","volume":"22","author":"Manzano","year":"1994","journal-title":"Actas Luso Esp Neurol Psiquiatr Cienc Afines"},{"key":"2025121400043745000_12.11.e052704.36","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"2025121400043745000_12.11.e052704.37","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.9.1136"},{"key":"2025121400043745000_12.11.e052704.38","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200304000-00008"},{"key":"2025121400043745000_12.11.e052704.39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1975.tb00927.x"},{"key":"2025121400043745000_12.11.e052704.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(01)72040-4"},{"key":"2025121400043745000_12.11.e052704.41","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"2025121400043745000_12.11.e052704.42","first-page":"767","article-title":"[Revalidation and standardization of the cognition mini-exam (first Spanish version of the Mini-Mental Status Examination) in the general geriatric population]","volume":"112","author":"Lobo","year":"1999","journal-title":"Med Clin"},{"key":"2025121400043745000_12.11.e052704.43","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/27.3.399"},{"key":"2025121400043745000_12.11.e052704.44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S1726-46342011000100005","article-title":"Validation of the clock drawing test - manos \u0301 version - as a screening test for detection of dementia in older persons of Lima; Peru","volume":"28","author":"Custodio","year":"2011","journal-title":"Rev Peru Med Exp Salud P\u00fablica"},{"key":"2025121400043745000_12.11.e052704.45","unstructured":"ONEI (Oficina Nacional de Estad\u00edstica e Informaci\u00f3n) . Statistical Yearbook of Baracoa, 2014. Guant\u00e1namo; 2015. http:\/\/www.onei.gob.cu\/node\/13577 [Accessed 21 Jan 2021]."},{"key":"2025121400043745000_12.11.e052704.46","unstructured":"ONEI (Oficina Nacional de Estad\u00edstica e Informaci\u00f3n) . Statistical Yearbook of Bejucal, 2014. Mayabeque; 2015. http:\/\/www.onei.gob.cu\/node\/13766 [Accessed 21 Jan 2021]."},{"key":"2025121400043745000_12.11.e052704.47","unstructured":"ONEI (Oficina Nacional de Estad\u00edstica e Informaci\u00f3n) . Statistical Yearbook of SANTA cruz del Norte, 2014. Mayabeque; 2015. http:\/\/www.onei.gob.cu\/node\/13449 [Accessed 21 Jan 2021]."},{"key":"2025121400043745000_12.11.e052704.48","unstructured":"Morales-Vallejo P . Necessary sample size: how many subjects do we need? In: Statistics applied to social sciences, 2008: 22\u201339. ISBN: 10: 8484682366."},{"key":"2025121400043745000_12.11.e052704.49","doi-asserted-by":"publisher","DOI":"10.3109\/00207459408986029"},{"key":"2025121400043745000_12.11.e052704.50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.14283\/jpad.2018.44","article-title":"Diet as a risk factor for cognitive decline in African Americans and Caucasians with a parental history of Alzheimer's disease: a cross-sectional pilot study dietary patterns","volume":"6","author":"Nutaitis","year":"2019","journal-title":"J Prev Alzheimers Dis"},{"key":"2025121400043745000_12.11.e052704.51","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515001452"},{"key":"2025121400043745000_12.11.e052704.52","first-page":"201","article-title":"Antioxidant potential of phenolic extracts of theobroma cacao L. (cocoa)","volume":"18","author":"Qui\u00f1ones","year":"2013","journal-title":"Rev Cubana Plant Med"},{"key":"2025121400043745000_12.11.e052704.53","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ajcn\/85.4.929","article-title":"The importance of fish and docosahexaenoic acid in Alzheimer disease","volume":"85","author":"Connor","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"2025121400043745000_12.11.e052704.54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3233\/JAD-2010-091315","article-title":"Is caffeine a cognitive enhancer?","volume":"20 Suppl 1","author":"Nehlig","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"2025121400043745000_12.11.e052704.55","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr118"},{"key":"2025121400043745000_12.11.e052704.56","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.9.1027"},{"key":"2025121400043745000_12.11.e052704.57","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1586\/14737175.2013.845086","article-title":"Non-pharmacological interventions and neuroplasticity in early stage Alzheimer's disease","volume":"13","author":"Herholz","year":"2013","journal-title":"Expert Rev Neurother"},{"key":"2025121400043745000_12.11.e052704.58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.nrl.2016.02.024","article-title":"The importance of behavioural and pyschological symptoms in Alzheimer disease","volume":"33","author":"P\u00e9rez Romero","year":"2018","journal-title":"Neurolog\u00eda"},{"key":"2025121400043745000_12.11.e052704.59","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1590\/0001-3765201520140716","article-title":"Alzheimer's disease associated with psychiatric comorbidities","volume":"87","author":"Garcez","year":"2015","journal-title":"An Acad Bras Cienc"},{"key":"2025121400043745000_12.11.e052704.60","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-3"},{"key":"2025121400043745000_12.11.e052704.61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000522042","article-title":"Sexuality and neurodegenerative disease: an unmet challenge for patients, caregivers, and treatment","volume":"21","author":"Eshmawey","year":"2021","journal-title":"Neurodegener Dis"},{"key":"2025121400043745000_12.11.e052704.62","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00619-0"},{"key":"2025121400043745000_12.11.e052704.63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/1877944111202010019","article-title":"Evidence that ingested aluminum additives contained in processed foods and alum-treated drinking water are a major risk factor for Alzheimers disease","volume":"2","author":"R. Walton","year":"2012","journal-title":"CIC"},{"key":"2025121400043745000_12.11.e052704.64","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.7.1377"},{"key":"2025121400043745000_12.11.e052704.65","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100013949"},{"key":"2025121400043745000_12.11.e052704.66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11910-020-01090-y","article-title":"Early-onset Alzheimer\u2019s disease: what Is missing in research?","volume":"21","author":"Ayodele","year":"2021","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2025121400043745000_12.11.e052704.67","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-1"},{"key":"2025121400043745000_12.11.e052704.68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2009.11.2\/cqiu","article-title":"Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention","volume":"11","author":"Qiu","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"key":"2025121400043745000_12.11.e052704.69","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319148"},{"key":"2025121400043745000_12.11.e052704.70","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-324306"},{"key":"2025121400043745000_12.11.e052704.71","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1563"},{"key":"2025121400043745000_12.11.e052704.72","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez J , Chaves R , G\u00f3rriz JM . SPECT Image Classification Techniques for Computer Aided Diagnosis of the Alzheimer Disease. In: Springer Cabestany J , Sandoval F , Prieto A , et al , eds. Bio-Inspired systems: computational and ambient intelligence. 5517. Berlin, Heidelberg: IWANN. Lecture Notes in Computer Science, 2009.","DOI":"10.1007\/978-3-642-02478-8_118"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-052704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:04:51Z","timestamp":1765699491000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-052704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":72,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/bmjopen-2021-052704"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-052704","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}