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Measures to limit the spread of the virus were implemented, including complete lockdown (26 March). Nonetheless, the virus spread throughout the country, with a first peak of almost a million cases in October. On 30 November, the government\u2019s recommendation switched from social, preventive and compulsory isolation, to social, preventive and compulsory distancing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe a tailored public health strategy to mitigate the spread of SARS-CoV-2 and determine its behaviour in San Antonio de Areco district from Buenos Aires province (Argentina) through a private\u2013public association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting and participants<\/jats:title>\n                    <jats:p>Surveillance of the virus was performed with the local healthcare system, through early identification of cases and the systematic study of each infected individual and contact, regardless of symptomatology, using telemedicine and a COVID-19-specific outpatient clinic. Real-time PCR was used for detection using both individual and pooled samples, with a 12-hour turnaround time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Up to 30 November, a total of 2426 suspected cases were analysed and 578 were confirmed. Surveillance of health personnel and at-risk populations proved effective, mitigating viral spread. Pooling samples allowed reduction of operator time, helped reduce costs, and allowed detection of both symptomatic and asymptomatic cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After 8 months of protocol implementation, the strategy to intensively survey groups at higher epidemiological risk and the systematic search for asymptomatic cases with the incorporation of pooled PCR for diagnosis, in combination with individual testing, is an efficient and viable option in populations with similar characteristics, in the frame of social isolation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-053595","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T12:20:37Z","timestamp":1637929237000},"page":"e053595","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a public health intervention for active surveillance and mitigation of SARS-CoV-2 in a district from Buenos Aires province, Argentina: a descriptive epidemiological study"],"prefix":"10.1136","volume":"11","author":[{"given":"Favio","family":"Crudo","sequence":"first","affiliation":[{"name":"Mundo Sano Foundation, Buenos Aires, Argentina"},{"name":"Association for Regional Health Development (ADESAR), San Antonio de Areco, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Mundo Sano Foundation, Buenos Aires, Argentina"},{"name":"Association for Regional Health Development (ADESAR), San Antonio de Areco, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Rodr\u00edguez Fermep\u00edn","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry, Chair of Clinical Microbiology\/INFIBIOC, Buenos Aires University, Buenos Aires, Argentina"},{"name":"Hospital de Cl\u00ednicas \u2018Jos\u00e9 de San Mart\u00edn\u2019, Laboratory of Immunology and Clinical Virology, Buenos Aires University, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Carolina","family":"Entrocassi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry, Chair of Clinical Microbiology\/INFIBIOC, Buenos Aires University, Buenos Aires, Argentina"},{"name":"Hospital de Cl\u00ednicas \u2018Jos\u00e9 de San Mart\u00edn\u2019, Laboratory of Immunology and Clinical Virology, Buenos Aires University, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Angela","family":"Cardone","sequence":"additional","affiliation":[{"name":"Health Secretariat of San Antonio de Areco, San Antonio de Areco, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Spina Markmann","sequence":"additional","affiliation":[{"name":"Health Secretariat of San Antonio de Areco, San Antonio de Areco, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-5146","authenticated-orcid":false,"given":"Maria Victoria","family":"Periago","sequence":"additional","affiliation":[{"name":"Mundo Sano Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technical Research, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Chuit","sequence":"additional","affiliation":[{"name":"Institute of Epidemiological Research, National Academy of Medicine, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Claudio","family":"Abril","sequence":"additional","affiliation":[{"name":"Mundo Sano Foundation, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"2025121223592964000_11.11.e053595.1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000507423","article-title":"COVID-19 outbreak: an overview","volume":"64","author":"Ciotti","year":"2019","journal-title":"Chemotherapy"},{"key":"2025121223592964000_11.11.e053595.2","unstructured":"WHO coronavirus disease (COVID-19) Dashboard. 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