{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:56:15Z","timestamp":1773071775511,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"unspecified","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2019-00198"],"award-info":[{"award-number":["2019-00198"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish heart-Lung Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Odense University Hospital","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,11,11]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Emerging evidence supports that PR interval prolongation is associated with increased mortality. However, most previous studies have limited confounder control, and clinical impact in a population of acute ill patients is unknown. The aim of this study was to investigate whether 1-year all-cause mortality was increased in patients presenting with PR interval prolongation in the emergency department (ED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>We conducted a register-based cohort study in two Swedish and two Danish EDs. We included all adult patients with an ECG performed at arrival to the Danish EDs during March 2013 to May 2014 and Swedish EDs during January 2010 to January 2011. Using propensity score matching, we analysed HR for 1-year all-cause mortality comparing patients with PR interval prolongation (&gt;200 ms) and normal PR interval (120\u2013200 ms).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants and results<\/jats:title>\n                    <jats:p>We included 106\u2009124 patients. PR interval prolongation occurred in 8.9% (95% CI 8.7% to 9.0%); these patients were older and had more comorbidity than those with a normal PR interval. The absolute 1-year risk of death was 13% (95% CI 12.3% to 13.7%) for patients with PR interval prolongation and 7.9% (95% CI 7.7% to 8.0%) for those without. After confounder adjustments by propensity score matching, PR interval prolongation showed no association with 1-year mortality with a HR of 1.00 (95% CI 0.93% to 1.08%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PR interval prolongation does not constitute an independent risk factor for 1-year mortality in ED patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-054238","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:51:49Z","timestamp":1639482709000},"page":"e054238","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["PR interval prolongation and 1-year mortality among emergency department patients: a multicentre transnational cohort study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-856X","authenticated-orcid":false,"given":"Rune","family":"Vad","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Odense University Hospital, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias Malte","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Odense University Hospital, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Kildegaard","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"Brabrand","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Southwest Jutland Hospital Esbjerg, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Lundager Forberg","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Prehospital Care, Helsingborgs lasarett, Helsingborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Lunds Universitet, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Pottegard","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4942-6152","authenticated-orcid":false,"given":"Annmarie Touborg","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Odense University Hospital, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"2025121604591957000_11.12.e054238.1","first-page":"932","article-title":"2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: Executive summary: a report of the American College of Cardiology\/American heart association Task force on clinical practice guidelines, and the heart rhythm Society","volume":"140","author":"Kusumoto","year":"2019","journal-title":"Circulation"},{"key":"2025121604591957000_11.12.e054238.2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308956"},{"key":"2025121604591957000_11.12.e054238.3","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318207a35f"},{"key":"2025121604591957000_11.12.e054238.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht176"},{"key":"2025121604591957000_11.12.e054238.5","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-017-0667-2","article-title":"PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights","volume":"17","author":"Chan","year":"2017","journal-title":"BMC Cardiovasc Disord"},{"key":"2025121604591957000_11.12.e054238.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.975342"},{"key":"2025121604591957000_11.12.e054238.7","article-title":"Diagnostic packages can be assigned accurately in emergency departments. 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