{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:36:14Z","timestamp":1760834174160,"version":"build-2065373602"},"reference-count":45,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Psychiatric Research Unit","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Region Zealand Psychiatry East","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,9,20]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The atypical antipsychotic clozapine has shown superior efficacy compared with other antipsychotics and is the gold standard for treating otherwise treatment resistant schizophrenia. However, multiple studies have found that clozapine is underutilised in most parts of the world. A few reviews of literature addressing barriers to clozapine prescribing have been conducted. While there is some variation in the literature included in these reviews, a common feature of the studies included is that they primarily focus on clinical staff\u2019s attitudes and perceived barriers for prescribing. Studies of patient perspectives are only sparsely included. A preliminary literature search revealed though, that additional literature on the subject exists, including literature on patient perspectives. It is therefore difficult to conclude if the formerly synthesised literature is representative of current evidence or if the topic has been adequately investigated to inform clinical practice. A scoping review is warranted in order to map and synthesise primary literature on patients\u2019 and psychiatrists\u2019 perspectives on clozapine treatment, and to identify gaps for future research.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The electronic databases Cochrane Library, CINAHL, Web of Science, Psychinfo, MEDLINE and EMBASE will be searched for relevant publications, supplied with searches of Google scholar, The Networked Digital Library of Theses and Dissertations and OpenGrey. Citation tracking of selected studies will furthermore be undertaken. Two researchers will independently screen and extract data. Data will be collated to provide a descriptive summary of the literature, along with a qualitative content analysis of key findings. Identified gaps in research will be accompanied by recommendations for future investigations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>Findings will be disseminated through a peer-reviewed journal and conference presentations. The scoping review does not require ethics approval.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-054308","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T23:59:16Z","timestamp":1633823956000},"page":"e054308","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Patients\u2019 and psychiatrists\u2019 perspectives on clozapine treatment\u2014a scoping review protocol"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-9074","authenticated-orcid":false,"given":"Michelle Iris","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Kobenhavn, Denmark"},{"name":"Early Psychosis Intervention Center, Psychiatric Services Region Zealand East, Roskilde, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-7745","authenticated-orcid":false,"given":"Ole Jakob","family":"Storeb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Southern Denmark, Faculty of Health Sciences, Odense, Denmark"},{"name":"Psychiatric Research Unit, Psychiatric Services Region Zealand, Slagelse, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Fitzgerald","family":"Austin","sequence":"additional","affiliation":[{"name":"Early Psychosis Intervention Center, Psychiatric Services Region Zealand East, Roskilde, Denmark"},{"name":"Psychiatric Research Unit, Psychiatric Services Region Zealand, Slagelse, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmi","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Kobenhavn, Denmark"},{"name":"Psychiatric Centre Glostrup, Unit for Complicated Schizophrenia, Mental Health Services in the Capital Region of Denmark, Kobenhavn, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Kobenhavn, Denmark"},{"name":"Psychiatric Research Unit, Psychiatric Services Region Zealand, Slagelse, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"doi-asserted-by":"publisher","key":"2025101811055960000_11.10.e054308.1","DOI":"10.1093\/schbul\/sbz041"},{"key":"2025101811055960000_11.10.e054308.2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/jamapsychiatry.2018.0623","article-title":"Comparison of early intervention services vs treatment as usual for early-phase psychosis: a systematic review, meta-analysis, and meta-regression","volume":"75","author":"Correll","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"2025101811055960000_11.10.e054308.3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1176\/appi.ps.201400558","article-title":"Early predictors of ten-year course in First-Episode psychosis","volume":"67","author":"Friis","year":"2016","journal-title":"Psychiatr Serv"},{"doi-asserted-by":"crossref","unstructured":"Kane JM , Agid O , Baldwin ML , et al . 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