{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:04:58Z","timestamp":1792523098236,"version":"4.5.0"},"reference-count":38,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K17675"],"award-info":[{"award-number":["JP17K17675"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K11653"],"award-info":[{"award-number":["JP21K11653"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,4,6]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Functional ability, or the ability to live actively in older age, is essential for healthy ageing. This study assessed the association between the five types of lower urinary tract symptoms (LUTS) and functional ability among community-dwelling older adults (\u226565 years old).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Community-dwelling older adults (\u226565 years old) randomly selected from the basic resident register of Kashiwa city as part of the Kashiwa study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study included 916 community-dwelling older adults (481 male participants) in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>A self-administered questionnaire was used to collect data regarding LUTS, which included frequency, nocturia, urgency, urinary incontinence and overactive bladder (OAB). Functional ability was measured using the Japan Science and Technology Agency Index of Competence. Sex-stratified logistic regression analyses were conducted, adjusting age, obesity, alcohol consumption, polypharmacy and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Male participants experienced symptoms of frequency, nocturia, urgency, urinary incontinence and OAB at rates of 68.0%, 89.0%, 16.0%, 3.7% and 4.3%, respectively. Female participants experienced these symptoms at rates of 68.3%, 80.0%, 11.0%, 7.4% and 8.5%, respectively. Among male participants, lower functional ability was only associated with nocturia (\u22653 times\/night) (adjusted OR (AOR): 1.71, 95% CI 1.05 to 2.79). Contrarily, lower functional ability among female participants was significantly associated with frequency (AOR: 1.61, 95% CI 1.04 to 2.49), urgency (AOR: 2.06, 95% CI 1.08 to 3.95) and OAB (AOR: 2.43, 95% CI 1.15 to 5.11).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The different associations between LUTS and functional ability by sex might be related to differences in the effect of comorbidities and physical fatigue. Our results help clarify the multifaceted effects of LUTS in old age, the need for early detection and treatment of LUTS, and the importance of maintaining functional ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-054530","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T08:07:52Z","timestamp":1652774872000},"page":"e054530","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Lower urinary tract symptoms and functional ability in older adults: a community-based cross-sectional study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-1049","authenticated-orcid":false,"given":"Kyo","family":"Takahashi","sequence":"first","affiliation":[{"name":"Institute of Gerontology, The University of Tokyo, Bunkyo-ku, Japan"},{"name":"Department of Public Health, School of Medicine, Dokkyo Medical University, Shimotsuga-gun, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, The University of Tokyo, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"School of Nursing, Tokyo Women\u2019s Medical University, Shinjuku-ku, Japan"},{"name":"Sportology Center, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahiro","family":"Fujisaki-Sueda-Sakai","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, The University of Tokyo, Bunkyo-ku, Japan"},{"name":"Department of Public Health Nursing, School of Health Science, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Kyung","family":"Son","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, The University of Tokyo, Bunkyo-ku, Japan"},{"name":"Institute for Future Initiatives, The University of Tokyo, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Iijima","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, The University of Tokyo, Bunkyo-ku, Japan"},{"name":"Institute for Future Initiatives, The University of Tokyo, Bunkyo-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"2025121411370499000_12.4.e054530.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.03.008"},{"key":"2025121411370499000_12.4.e054530.2","unstructured":"World Health Organization . Ageing and life-course, 2020. Available: https:\/\/www.who.int\/ageing\/healthy-ageing\/en\/ [Accessed 06 Aug 2020]."},{"key":"2025121411370499000_12.4.e054530.3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/jgs.15644","article-title":"Healthy aging: American geriatrics Society white paper executive summary","volume":"67","author":"Friedman","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"2025121411370499000_12.4.e054530.4","unstructured":"Abrams P , Cardozo L , Wagg A . Incontinence. 6th ed. International Continence Society, 2017."},{"key":"2025121411370499000_12.4.e054530.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09993.x"},{"key":"2025121411370499000_12.4.e054530.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"2025121411370499000_12.4.e054530.7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/nau.23875","article-title":"Prevalence and impact of lower urinary tract symptoms: results of the EPIC survey in Egypt","volume":"38","author":"Mourad","year":"2019","journal-title":"Neurourol Urodyn"},{"key":"2025121411370499000_12.4.e054530.8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/nau.23035","article-title":"Can we define and characterize the aging lower urinary tract?-ICI-RS 2015","volume":"36","author":"Vahabi","year":"2017","journal-title":"Neurourol Urodyn"},{"key":"2025121411370499000_12.4.e054530.9","doi-asserted-by":"publisher","DOI":"10.1159\/000437336"},{"key":"2025121411370499000_12.4.e054530.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07601.x"},{"key":"2025121411370499000_12.4.e054530.11","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/nau.24004","article-title":"Impact of LUTS on treatment-related behaviors and quality of life: a population-based study in Brazil","volume":"38","author":"Soler","year":"2019","journal-title":"Neurourol Urodyn"},{"key":"2025121411370499000_12.4.e054530.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.065"},{"key":"2025121411370499000_12.4.e054530.13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00192-014-2505-8","article-title":"The interaction of stress and urgency urinary incontinence and its effect on quality of life","volume":"26","author":"Minassian","year":"2015","journal-title":"Int Urogynecol J"},{"key":"2025121411370499000_12.4.e054530.14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/nau.20913","article-title":"Nocturia research: current status and future perspectives","volume":"29","author":"Van Kerrebroeck","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"2025121411370499000_12.4.e054530.15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17843286.2019.1660022","article-title":"Prevalence and characteristics of incident falls related to nocturnal toileting in hospitalized patients","volume":"76","author":"Decalf","year":"2021","journal-title":"Acta Clin Belg"},{"key":"2025121411370499000_12.4.e054530.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.093"},{"key":"2025121411370499000_12.4.e054530.17","doi-asserted-by":"publisher","DOI":"10.5213\/inj.2010.14.3.133"},{"key":"2025121411370499000_12.4.e054530.18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/nau.22615","article-title":"Urinary incontinence and disability in community-dwelling women: a cross-sectional study","volume":"34","author":"Greer","year":"2015","journal-title":"Neurourol Urodyn"},{"key":"2025121411370499000_12.4.e054530.19","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/jgs.17633","article-title":"Lower urinary tract symptoms and incident functional limitations among older community-dwelling men","volume":"70","author":"Bauer","year":"2022","journal-title":"J Am Geriatr Soc"},{"key":"2025121411370499000_12.4.e054530.20","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"2025121411370499000_12.4.e054530.21","doi-asserted-by":"crossref","DOI":"10.1177\/2333721415609490","article-title":"Development of the Japan science and technology agency index of competence to assess functional capacity in older adults: conceptual definitions and preliminary items","volume":"1","author":"Iwasa","year":"2015","journal-title":"Gerontol Geriatr Med"},{"key":"2025121411370499000_12.4.e054530.22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s40520-017-0786-8","article-title":"Assessing competence at a higher level among older adults: development of the Japan science and technology agency index of competence (JST-IC)","volume":"30","author":"Iwasa","year":"2018","journal-title":"Aging Clin Exp Res"},{"key":"2025121411370499000_12.4.e054530.23","unstructured":"International Continence Society . Ics glossary, 2021. Available: https:\/\/www.ics.org\/glossary [Accessed 08 Mar 2020]."},{"key":"2025121411370499000_12.4.e054530.24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1464-410X.2009.08438.x","article-title":"Risk factors and comorbid conditions associated with lower urinary tract symptoms: EpiLUTS","volume":"103 Suppl 3","author":"Coyne","year":"2009","journal-title":"BJU Int"},{"key":"2025121411370499000_12.4.e054530.25","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/ijcp.12727","article-title":"Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study","volume":"69","author":"Madhu","year":"2015","journal-title":"Int J Clin Pract"},{"key":"2025121411370499000_12.4.e054530.26","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.juro.2011.11.085","article-title":"Alcohol consumption shows a J-shaped association with lower urinary tract symptoms in the general screening population","volume":"187","author":"Oh","year":"2012","journal-title":"J Urol"},{"key":"2025121411370499000_12.4.e054530.27","doi-asserted-by":"publisher","DOI":"10.1007\/s00391-012-0358-7"},{"key":"2025121411370499000_12.4.e054530.28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/luts.12046","article-title":"Men with hypertension are more likely to have severe lower urinary tract symptoms and large prostate volume","volume":"7","author":"Hwang","year":"2015","journal-title":"Low Urin Tract Symptoms"},{"key":"2025121411370499000_12.4.e054530.29","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.eururo.2016.07.007","article-title":"Male lower urinary tract symptoms and cardiovascular events: a systematic review and meta-analysis","volume":"70","author":"Gacci","year":"2016","journal-title":"Eur Urol"},{"key":"2025121411370499000_12.4.e054530.30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00152192-200611000-00005","article-title":"Urinary incontinence and diabetes: a review","volume":"33","author":"Smith","year":"2006","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"2025121411370499000_12.4.e054530.31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.urology.2013.03.001","article-title":"Risk factors for male lower urinary tract symptoms: the role of metabolic syndrome and androgenetic alopecia in a Latin American population","volume":"82","author":"Barbosa","year":"2013","journal-title":"Urology"},{"key":"2025121411370499000_12.4.e054530.32","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1016\/j.clinthera.2020.11.003","article-title":"Comorbidities, age, and polypharmacy limit the use by US older adults with nocturia of the only FDA-approved drugs for the symptom","volume":"42","author":"Suvada","year":"2020","journal-title":"Clin Ther"},{"key":"2025121411370499000_12.4.e054530.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.10.022"},{"key":"2025121411370499000_12.4.e054530.34","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/cncr.32590","article-title":"Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan","volume":"126","author":"Zaitsu","year":"2020","journal-title":"Cancer"},{"key":"2025121411370499000_12.4.e054530.35","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"2025121411370499000_12.4.e054530.36","unstructured":"World Health Organization . International classification of functioning, disability and health. World Health Organization, 2001."},{"key":"2025121411370499000_12.4.e054530.37","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1447-0756.2008.01000.x","article-title":"Urine leakage related to physical fatigue in women with urinary stress incontinence","volume":"35","author":"Deffieux","year":"2009","journal-title":"J Obstet Gynaecol Res"},{"key":"2025121411370499000_12.4.e054530.38","unstructured":"Japanese Society for the Study of Obesity . Guidelines for the management of obesity disease (in Japanese), 2016."}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-054530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:37:18Z","timestamp":1765741038000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-054530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,25]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bmjopen-2021-054530"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-054530","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}