{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:47:34Z","timestamp":1788173254140,"version":"build-2803163510"},"reference-count":46,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"First Affiliated Hospital of Guangzhou Medical University","award":["ZH201822"],"award-info":[{"award-number":["ZH201822"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,5,15]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe 6-min walk test (6MWT) outcomes, and to investigate their correlations with cardiopulmonary and lung function among patients with interstitial lung disease (ILD) which was not limited to idiopathic pulmonary fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected patients\u2019 demographic data and obtained minute-by-minute 6MWT outcomes. Modified Borg scale was employed to assess patients\u2019 dyspnoea, whereas New York Heart Association (NYHA) classification and pulmonary function test were used to evaluate patients\u2019 cardiopulmonary functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Heart rate (HR) exhibited a continuous upward trend, while SpO\n                      <jats:sub>2<\/jats:sub>\n                      exhibited an overall downward with a slight increase at the fifth minute. The SpO\n                      <jats:sub>2<\/jats:sub>\n                      nadir for 70 patients (9.3%) was lower than 80%. Further, the SpO\n                      <jats:sub>2<\/jats:sub>\n                      nadir for 78.27% of the participants appeared at the end of the fourth minute. The 6-min walk distance (6MWD) had the strongest correlation with NYHA classification (\n                      <jats:italic>r=<\/jats:italic>\n                      0.82, p\n                      <jats:italic>&lt;<\/jats:italic>\n                      0.01). The ratio of 6MWD to predicted 6MWD was most correlated to forced expiratory volume in the first second (\n                      <jats:italic>r=<\/jats:italic>\n                      0.30, p\n                      <jats:italic>&lt;<\/jats:italic>\n                      0.01) and forced vital capacity (\n                      <jats:italic>r=<\/jats:italic>\n                      0.30, p\n                      <jats:italic>&lt;<\/jats:italic>\n                      0.01). SpO\n                      <jats:sub>2<\/jats:sub>\n                      at 3\u2009min had the strongest correlation to patients\u2019 diffusing capacity of the lungs for carbon monoxide (\n                      <jats:italic>r=<\/jats:italic>\n                      0.41, p\n                      <jats:italic>&lt;<\/jats:italic>\n                      0.01). We found significant differences in 6MWD (\n                      <jats:italic>F<\/jats:italic>\n                      =2.44, p=0.033), SpO\n                      <jats:sub>2<\/jats:sub>\n                      change (\n                      <jats:italic>F<\/jats:italic>\n                      =2.58, p=0.025), HR at 0\u2009min (\n                      <jats:italic>F<\/jats:italic>\n                      =2.87, p=0.014), HR at end of 6\u2009min (\n                      <jats:italic>F<\/jats:italic>\n                      =2.58, p=0.025) and HR zenith (\n                      <jats:italic>F<\/jats:italic>\n                      =2.64, p=0.022) between the subtypes of ILD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This observation provided an important evidence regarding oxygen titration. It is better to maintain SpO\n                      <jats:sub>2<\/jats:sub>\n                      above 88% for 4\u2009min instead of 3\u2009min. SpO\n                      <jats:sub>2<\/jats:sub>\n                      at the third minute was the most valuable predictor of patients\u2019 lung function. 6MWD and SpO\n                      <jats:sub>2<\/jats:sub>\n                      changes were more discriminative in subtypes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055077","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T13:05:45Z","timestamp":1655298345000},"page":"e055077","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Features and predictive value of 6-min walk test outcomes in interstitial lung disease: an observation study using wearable monitors"],"prefix":"10.1136","volume":"12","author":[{"given":"Jiaying","family":"Li","sequence":"first","affiliation":[{"name":"School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaozhen","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyin","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqun","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4644-2325","authenticated-orcid":false,"given":"Xiaobing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"2025121222583550000_12.6.e055077.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000212"},{"key":"2025121222583550000_12.6.e055077.2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/resp.12320","article-title":"Transbronchial cryobiopsy in the diagnosis of interstitial lung disease: a cool new 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