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Such tools could be derived from neurophysiological measurements of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The New Therapeutics in Alzheimer\u2019s Disease study (NTAD) aims to identify a biomarker set from magneto\/electroencephalography that is sensitive to disease and progression over 1\u2009year. The study will recruit 100 people with amyloid-positive mild cognitive impairment or early-stage Alzheimer\u2019s disease and 30 healthy controls aged between 50 and 85 years. Measurements of the clinical, cognitive and imaging data (magnetoencephalography, electroencephalography and MRI) of all participants will be taken at baseline. These measurements will be repeated after approximately 1\u2009year on participants with Alzheimer\u2019s disease or mild cognitive impairment, and clinical and cognitive assessment of these participants will be repeated again after approximately 2\u2009years. To assess reliability of magneto\/electroencephalographic changes, a subset of 30 participants with mild cognitive impairment or early-stage Alzheimer\u2019s disease will also undergo repeat magneto\/electroencephalography 2\u2009weeks after baseline. Baseline and longitudinal changes in neurophysiology are the primary analyses of interest. Additional outputs will include atrophy and cognitive change and estimated numbers needed to treat each arm of simulated clinical trials of a future disease-modifying therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and data statement<\/jats:title>\n                    <jats:p>The study has received a favourable opinion from the East of England Cambridge Central Research Ethics Committee (REC reference 18\/EE\/0042). Results will be disseminated through internal reports, peer-reviewed scientific journals, conference presentations, website publication, submission to regulatory authorities and other publications. Data will be made available via the Dementias Platform UK Data Portal on completion of initial analyses by the NTAD study group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055135","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:10:55Z","timestamp":1671106255000},"page":"e055135","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["New Therapeutics in Alzheimer\u2019s Disease Longitudinal Cohort study (NTAD): study protocol"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-7686","authenticated-orcid":false,"given":"Juliette 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