{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:47Z","timestamp":1787017067693,"version":"build-2736575974"},"reference-count":37,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ALF-agreement","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,10,12]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Ambidirectional observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>All 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Findings on brain MRI, neurocognitive test results and reported fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and\/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055164","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T13:16:23Z","timestamp":1635340583000},"page":"e055164","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4099-9456","authenticated-orcid":false,"given":"Lovisa","family":"Hellgren","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine in J\u00f6nk\u00f6ping, J\u00f6nk\u00f6ping Region, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Birberg Thornberg","sequence":"additional","affiliation":[{"name":"Department of Rehabiliation Medicine in Link\u00f6ping, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kersti","family":"Samuelsson","sequence":"additional","affiliation":[{"name":"Department of Rehabiliation Medicine in Link\u00f6ping, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Rehabiliation Medicine in Link\u00f6ping, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anestis","family":"Divanoglou","sequence":"additional","affiliation":[{"name":"Department of Rehabiliation Medicine in Link\u00f6ping, and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Blystad","sequence":"additional","affiliation":[{"name":"Department of Radiology in Link\u00f6ping and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Centre for Medical Image Science and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"2025120600171008000_11.10.e055164.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.028"},{"key":"2025120600171008000_11.10.e055164.2","doi-asserted-by":"crossref","first-page":"e1060","DOI":"10.1212\/WNL.0000000000009937","article-title":"Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry","volume":"95","author":"Romero-S\u00e1nchez","year":"2020","journal-title":"Neurology"},{"key":"2025120600171008000_11.10.e055164.3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa240"},{"key":"2025120600171008000_11.10.e055164.4","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202422"},{"key":"2025120600171008000_11.10.e055164.5","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.2020202791","article-title":"Nervous system involvement in coronavirus disease 2019: results from a retrospective consecutive neuroimaging cohort","volume":"297","author":"Klironomos","year":"2020","journal-title":"Radiology"},{"key":"2025120600171008000_11.10.e055164.6","doi-asserted-by":"crossref","first-page":"100484","DOI":"10.1016\/j.eclinm.2020.100484","article-title":"Cerebral micro-structural changes in COVID-19 Patients - 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