{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:15:08Z","timestamp":1787879708518,"version":"build-2784847793"},"reference-count":58,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Royal Golden Jubilee Ph.D. Program\u2013RGJ","award":["PHD\/0183\/2561"],"award-info":[{"award-number":["PHD\/0183\/2561"]}]},{"name":"Targeted Research Grants Program of the Faculty of Medicine, Prince of Songkla University"},{"name":"TSRI Research Career Development Grand\u2013RSA","award":["RSA6180009"],"award-info":[{"award-number":["RSA6180009"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,6,1]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the levels of blood pressure, cardiovascular biomarkers and their correlations measured within 7 years postpartum in women with previous pre-eclamptic pregnancies compared with women with previous normotensive pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Two tertiary hospitals in the southern region of Thailand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Women with pre-eclamptic and normotensive pregnancies in the past 7 years were enrolled from 1 October 2019 to 30 April 2021. Eligible women were interviewed, examined for body mass index (BMI) and blood pressure, and donated morning spot urine and blood samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome measures<\/jats:title>\n                    <jats:p>\n                      Serum high-sensitivity C reactive protein, creatinine, fasting blood glucose (FBS), glycated haemoglobin (HbA1c), low-density lipoprotein (LDL) cholesterol, urine microalbumin to creatinine ratio (UACR) and sodium were measured. Group differences in biomarkers were tested using unpaired t-test, Wilcoxon rank-sum test or \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test. The levels of blood pressure and biomarkers between the two study groups at &lt;2 years, 2\u20134 years and &gt;4 years were also compared. The correlations between blood pressure and biomarkers were analysed using Pearson\u2019s correlation and partial correlation methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 206 women included in the analysis, 88 had pre-eclamptic pregnancies and 118 had normotensive pregnancies. Compared with women with previous normotensive pregnancies, women with previous pre-eclamptic pregnancies had significantly increased rates of hypertension (31.8% vs 7.6%, p&lt;0.001) and obesity (55.7% vs 40.7%, p=0.038), as well as higher serum levels of FBS (p&lt;0.001), HbA1c (p&lt;0.001), LDL cholesterol (p=0.03), creatinine (p&lt;0.001) and UACR (p&lt;0.001). Correlation coefficients of BMI, serum creatinine and UACR with blood pressure ranged from 0.27 to 0.31.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The risk of hypertension after a pre-eclamptic pregnancy increased. Blood pressure measurement combined with BMI, serum creatinine and UACR screening at least once during 7 years postpartum is suggested for early detection of cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055534","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T13:05:58Z","timestamp":1655298358000},"page":"e055534","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Levels of blood pressure, cardiovascular biomarkers and their correlations in women with previous pre-eclamptic pregnancy within 7 years postpartum: a cross-sectional study in Thailand"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-2465","authenticated-orcid":false,"given":"Jarawee","family":"Sukmanee","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, 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