{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:20:56Z","timestamp":1789035656966,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hjerne- og Nervekirurgisk forskningspulje","award":["F-23026-02, N497"],"award-info":[{"award-number":["F-23026-02, N497"]}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["F-22218-19"],"award-info":[{"award-number":["F-22218-19"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n<jats:title>Introduction<\/jats:title>\n<jats:p>Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread treatment for hydrocephalus, but research is primarily based on paediatric populations. In 2009, Kulkarni<jats:italic>et al<\/jats:italic>created the ETV Success score to predict the outcome of ETV in children. The purpose of this study is to create a prognostic model to predict the success of ETV for adult patients with hydrocephalus. The ability to predict who will benefit from an ETV will allow better primary patient selection both for ETV and shunting. This would reduce additional second procedures due to primary treatment failure. A success score specific for adults could also be used as a communication tool to provide better information and guidance to patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods and analysis<\/jats:title>\n<jats:p>The study will adhere to the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis reporting guidelines and conducted as a retrospective chart review of all patients\u226518 years of age treated with ETV at the participating centres between 1 January 2010 and 31 December 2018. Data collection is conducted locally in a standardised database. Univariate analysis will be used to identify several strong predictors to be included in a multivariate logistic regression model. The model will be validated using K-fold cross validation. Discrimination will be assessed using area under the receiver operating characteristic curve (AUROC) and calibration with calibration belt plots.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Ethics and dissemination<\/jats:title>\n<jats:p>The study is approved by appropriate ethics or patient safety boards in all participating countries.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Trial registration number<\/jats:title>\n<jats:p>\n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\" xlink:href=\"NCT04773938\">NCT04773938<\/jats:ext-link>; Pre-results.<\/jats:p>\n<\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055570","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T12:26:47Z","timestamp":1669724807000},"page":"e055570","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Endoscopic third ventriculostomy for adults with hydrocephalus: creating a prognostic model for success: protocol for a retrospective multicentre study (Nordic ETV)"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct04773938","registry":"10.18810\/clinical-trials-gov","type":"preResults"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-4440","authenticated-orcid":false,"given":"Sondre","family":"Tefre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-249X","authenticated-orcid":false,"given":"Alexander","family":"Lilja-Cyron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Arvidsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-1914","authenticated-orcid":false,"given":"Jiri","family":"Bartek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-2392","authenticated-orcid":false,"given":"Alba","family":"Corell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0325-0262","authenticated-orcid":false,"given":"Axel","family":"Forsse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-6120","authenticated-orcid":false,"given":"Andreas N\u00f8rgaard","family":"Glud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-8357","authenticated-orcid":false,"given":"Sami Abu","family":"Hamdeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik Lundgaard","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7212-5780","authenticated-orcid":false,"given":"Antti","family":"Huotarinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-7173","authenticated-orcid":false,"given":"Conny","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-3725","authenticated-orcid":false,"given":"Olli-Pekka","family":"K\u00e4m\u00e4r\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5500-9200","authenticated-orcid":false,"given":"Tommi","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-7786","authenticated-orcid":false,"given":"Anna","family":"Kotkansalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-3275","authenticated-orcid":false,"given":"Nadia Mauland","family":"Mansoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Erasmo","family":"Mendoza Mireles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-3497","authenticated-orcid":false,"given":"Rares","family":"Miscov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4793-9803","authenticated-orcid":false,"given":"Sune","family":"Munthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-8107","authenticated-orcid":false,"given":"Henrietta","family":"Nittby-Redebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Obad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Kjelsberg","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-5193","authenticated-orcid":false,"given":"Jussi","family":"Posti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4243-9591","authenticated-orcid":false,"given":"Rahul","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-0301","authenticated-orcid":false,"given":"Jarno","family":"Satop\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"St\u00e5hl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-9136","authenticated-orcid":false,"given":"Sami","family":"Tetri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-846X","authenticated-orcid":false,"given":"Lovisa","family":"Tobieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-7495","authenticated-orcid":false,"given":"Marianne","family":"Juhler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"2022112903182190000_12.1.e055570.1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11060-010-0393-4","article-title":"Ventriculoperitoneal shunt complications in hydrocephalus patients with intracranial tumors: an analysis of relevant risk factors","volume":"103","author":"Reddy","year":"2011","journal-title":"J Neurooncol"},{"key":"2022112903182190000_12.1.e055570.2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.wneu.2016.10.136","article-title":"The rate of complications after ventriculoperitoneal shunt surgery","volume":"98","author":"Merkler","year":"2017","journal-title":"World Neurosurg"},{"key":"2022112903182190000_12.1.e055570.3","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31821ffa9e"},{"key":"2022112903182190000_12.1.e055570.4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1227\/NEU.0000000000000994","article-title":"Endoscopic third ventriculostomy in 250 adults with hydrocephalus: patient selection, outcomes, and complications","volume":"78","author":"Grand","year":"2016","journal-title":"Neurosurgery"},{"key":"2022112903182190000_12.1.e055570.5","first-page":"643","article-title":"Complications of endoscopic third ventriculostomy","volume":"7","author":"Bouras","year":"2011","journal-title":"J Neurosurg"},{"key":"2022112903182190000_12.1.e055570.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.08.024"},{"key":"2022112903182190000_12.1.e055570.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.048"},{"key":"2022112903182190000_12.1.e055570.8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/02688697.2016.1229744","article-title":"Is the endoscopic third ventriculostomy success score an appropriate tool to inform clinical decision-making?","volume":"31","author":"Foley","year":"2017","journal-title":"Br J Neurosurg"},{"key":"2022112903182190000_12.1.e055570.9","doi-asserted-by":"crossref","DOI":"10.3171\/2016.6.FOCUS16193","article-title":"Endoscopic third ventriculostomy for treatment of adult hydrocephalus: long-term follow-up of 163 patients","volume":"41","author":"Isaacs","year":"2016","journal-title":"Neurosurg Focus"},{"key":"2022112903182190000_12.1.e055570.10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.wneu.2016.07.028","article-title":"Long-Term outcomes of endoscopic third ventriculostomy in adults","volume":"94","author":"Waqar","year":"2016","journal-title":"World Neurosurg"},{"key":"2022112903182190000_12.1.e055570.11","doi-asserted-by":"publisher","DOI":"10.3171\/2011.11.PEDS11495"},{"key":"2022112903182190000_12.1.e055570.12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-950382"},{"key":"2022112903182190000_12.1.e055570.13","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00381-013-2122-8","article-title":"An external validation of the ETVSS for both short-term and long-term predictive adequacy in 104 pediatric patients","volume":"29","author":"Breimer","year":"2013","journal-title":"Childs Nerv Syst"},{"key":"2022112903182190000_12.1.e055570.14","doi-asserted-by":"publisher","DOI":"10.3171\/2011.8.PEDS1166"},{"key":"2022112903182190000_12.1.e055570.15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3171\/2018.7.PEDS18220","article-title":"The long-term outcomes of endoscopic third ventriculostomy in pediatric hydrocephalus, with an emphasis on future intellectual development and shunt dependency","volume":"23","author":"Hong","year":"2018","journal-title":"J Neurosurg Pediatr"},{"key":"2022112903182190000_12.1.e055570.16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3171\/2017.1.PEDS16536","article-title":"The durability of endoscopic third ventriculostomy and ventriculoperitoneal shunts in children with hydrocephalus following posterior fossa tumor resection: a systematic review and time-to-failure analysis","volume":"19","author":"Dewan","year":"2017","journal-title":"J Neurosurg Pediatr"},{"key":"2022112903182190000_12.1.e055570.17","first-page":"734","article-title":"Long-Term follow-up of endoscopic third ventriculostomy performed in the pediatric population","volume":"17","author":"Stovell","year":"2016","journal-title":"J Neurosurg"},{"key":"2022112903182190000_12.1.e055570.18","doi-asserted-by":"crossref","DOI":"10.3171\/2011.1.FOCUS10303","article-title":"Long-Term operative failure of endoscopic third ventriculostomy in pediatric patients: the role of cine phase-contrast MR imaging","volume":"30","author":"Faggin","year":"2011","journal-title":"Neurosurg Focus"},{"key":"2022112903182190000_12.1.e055570.19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3171\/2017.2.PEDS16491","article-title":"Hydrocephalus treatment in children: long-term outcome in 975 consecutive patients","volume":"20","author":"Beuriat","year":"2017","journal-title":"J Neurosurg Pediatr"},{"key":"2022112903182190000_12.1.e055570.20","doi-asserted-by":"publisher","DOI":"10.3171\/2009.8.PEDS08108"},{"key":"2022112903182190000_12.1.e055570.21","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000159712.48093.AD"},{"key":"2022112903182190000_12.1.e055570.22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-2007-990305","article-title":"Long-Term outcome of endoscopic third ventriculostomy in obstructive hydrocephalus","volume":"50","author":"Gangemi","year":"2007","journal-title":"Minim Invasive Neurosurg"},{"key":"2022112903182190000_12.1.e055570.23","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3171\/2014.11.JNS14414","article-title":"Long-Term results of endoscopic third ventriculostomy: an outcome analysis","volume":"123","author":"Vulcu","year":"2015","journal-title":"J Neurosurg"},{"key":"2022112903182190000_12.1.e055570.24","first-page":"54","article-title":"The role of endoscopic third ventriculostomy in the treatment of hydrocephalus","volume":"12","author":"Vogel","year":"2013","journal-title":"J Neurosurg"},{"key":"2022112903182190000_12.1.e055570.25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000257525","article-title":"Endoscopic third ventriculostomy: the Lebanese experience","volume":"45","author":"Rahme","year":"2009","journal-title":"Pediatr Neurosurg"},{"key":"2022112903182190000_12.1.e055570.26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.clineuro.2014.03.022","article-title":"Ventriculocisternostomy versus ventriculoperitoneal shunt in the treatment of hydrocephalus: a retrospective, long-term observational study","volume":"122","author":"Gliemroth","year":"2014","journal-title":"Clin Neurol Neurosurg"},{"key":"2022112903182190000_12.1.e055570.27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.wneu.2011.09.018","article-title":"Predictors of surgery-free outcome in adult endoscopic third ventriculostomy","volume":"78","author":"Woodworth","year":"2012","journal-title":"World Neurosurg"},{"key":"2022112903182190000_12.1.e055570.28","doi-asserted-by":"crossref","unstructured":"Collins GS , Reitsma JB , Altman DG . Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ 2014;350.doi:10.1136\/bmj.g7594","DOI":"10.1136\/bmj.g7594"},{"key":"2022112903182190000_12.1.e055570.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m441"},{"key":"2022112903182190000_12.1.e055570.30","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/sim.6744","article-title":"A new test and graphical tool to assess the goodness of fit of logistic regression models","volume":"35","author":"Nattino","year":"2016","journal-title":"Stat Med"},{"key":"2022112903182190000_12.1.e055570.31","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S129785"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-055570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T12:27:15Z","timestamp":1669724835000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-055570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,31]]},"published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1136\/bmjopen-2021-055570"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-055570","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}