{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:11:08Z","timestamp":1783033868627,"version":"3.54.6"},"reference-count":56,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Korea Ministry of Health and Welfare","award":["NRCRSP-21TB01 and NRCRSP-22TB03"],"award-info":[{"award-number":["NRCRSP-21TB01 and NRCRSP-22TB03"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,12,2]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although various treatments exist for depression in patients with spinal cord injury (SCI), the comparative effects and relationships between these treatments have not been clearly presented. This study aims to present comprehensive evidence for the treatment of major depressive disorder or dysthymic disorder in patients with SCI by comparing the therapeutic and adverse effects of pharmacological and non-pharmacological treatments through a systematic review and network meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      We will search for studies in five databases (Medline, Central, Embase, PsycINFO and CHINAL) as well as clinical trial registries (US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n                      ), WHO International Clinical Trials Registry Platform (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.who.int\/trialsearch\">www.who.int\/trialsearch<\/jats:ext-link>\n                      )) and grey literature (Google Scholar). The references of the included studies, previous systematic reviews and meta-analyses will be reviewed. Study selection, data extraction and quality and risk of bias assessments will be independently performed by two authors (JMH and WSC), and disagreements will be resolved by discussion with JHK. Moreover, a Bayesian network meta-analysis will be performed using R software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Our systematic review and network meta-analysis will be performed based on existing studies; thus, we did not seek ethical approval. Our results will be published in a peer-reviewed journal and presented at both domestic and international conferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055800","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T09:55:37Z","timestamp":1671011737000},"page":"e055800","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of major depressive disorder (MDD) or dysthymic disorder (DD) in spinal cord injury (SCI) patients: a protocol for a systematic review and network meta-analysis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-2000","authenticated-orcid":false,"given":"Ji Min","family":"Han","sequence":"first","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seuk","family":"Choi","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2141-3483","authenticated-orcid":false,"given":"Bo-Hyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Kyung Hee University, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hyoung","family":"Son","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Park","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-6039","authenticated-orcid":false,"given":"Jung Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center, Korea Ministry of Health and Welfare, Sejong, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"2025120518393434000_12.12.e055800.1","unstructured":"Edition F . Diagnostic and statistical manual of mental disorders. Am Psychiatric Assoc 2013;21."},{"key":"2025120518393434000_12.12.e055800.2","first-page":"505","article-title":"Current status and diagnosis of depression","volume":"30","author":"Minsoo","year":"2013","journal-title":"Journal of Korean Society of Health-System Pharmacists"},{"key":"2025120518393434000_12.12.e055800.3","unstructured":"Psycom . Available: https:\/\/www.psycom.net\/depression-definition-dsm-5-diagnostic-criteria\/"},{"key":"2025120518393434000_12.12.e055800.4","unstructured":"Kwon J , Kim J , Nam G , et al . Diagnostic and statistical manual of mental disorders. 5th ed. Hakjisa, 2015."},{"key":"2025120518393434000_12.12.e055800.5","unstructured":"Substance Abuse and Mental Health Services Administration . Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health [Internet]. Rockville (MD) Substance Abuse and Mental Health Services Administration (US); 2016. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519704\/table\/ch3.t6\/"},{"key":"2025120518393434000_12.12.e055800.6","unstructured":"GHDx . Available: http:\/\/ghdx.healthdata.org\/gbd-results-tool?params=gbd-api-2019-permalink\/d780dffbe8a381b25e1416884959e88b [Accessed 01 May 2021]."},{"key":"2025120518393434000_12.12.e055800.7","unstructured":"WHO . Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression"},{"key":"2025120518393434000_12.12.e055800.8","unstructured":"WHO . The glossary of terms used, 2015. Available: https:\/\/www.who.int\/hia\/about\/glos\/en\/"},{"key":"2025120518393434000_12.12.e055800.9","first-page":"150","article-title":"10-Year Trajectories of Depressive Symptoms and Their Predictors:Inequity between People with and without Disabilities","volume":"37","author":"Changmin","year":"2017","journal-title":"Korea Institute for Health and Social Affairs"},{"key":"2025120518393434000_12.12.e055800.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.08.002"},{"key":"2025120518393434000_12.12.e055800.11","doi-asserted-by":"crossref","unstructured":"Bandura A . Self-efficacy: the exercise of control. New York, NY, US W H Freeman\/Times Books\/Henry Holt & Co; 1999: 158\u201366.","DOI":"10.1891\/0889-8391.13.2.158"},{"key":"2025120518393434000_12.12.e055800.12","unstructured":"Yongbum K . Correlates of depressive symptoms and suicidal ideation among Korean adults Jeju university graduate school; 2008."},{"key":"2025120518393434000_12.12.e055800.13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175141","article-title":"Incidence, risk, and associated factors of depression in adults with physical and sensory disabilities: a nationwide population-based study","volume":"12","author":"Shen","year":"2017","journal-title":"PLoS One"},{"key":"2025120518393434000_12.12.e055800.14","unstructured":"Bryce TN . Spinal cord injury Demos Medical; 2010."},{"key":"2025120518393434000_12.12.e055800.15","unstructured":"Orenczuk S , Mehta S , Slivinski J , et al . Depression Following Spinal Cord Injury. In: Eng JJ , Teasell RW , Miller WC , eds. Spinal cord injury rehabilitation evidence, 2014: Version5.0:1-35."},{"key":"2025120518393434000_12.12.e055800.16","first-page":"1","article-title":"Study on factors affecting on the spinal cord injuries\u2019 social integration using the structural equation model: Analyzing mediating effect of depression, disability identity","volume":"11","author":"Eunkyoung","year":"2007","journal-title":"Journal of Rehabilitation Research"},{"key":"2025120518393434000_12.12.e055800.17","first-page":"185","article-title":"A study on variables relating to marital satisfaction of the spinal cord injury couples","volume":"5","author":"Yangsook","year":"2000","journal-title":"Korean Academy of Family Social Work"},{"key":"2025120518393434000_12.12.e055800.18","first-page":"91","article-title":"Chronologic age, time since injury, and time of measurement: effect on adjustment after spinal cord injury","volume":"72","author":"Krause","year":"1991","journal-title":"Arch Phys Med Rehabil"},{"key":"2025120518393434000_12.12.e055800.19","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.115"},{"key":"2025120518393434000_12.12.e055800.20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/jamapsychiatry.2014.2482","article-title":"Venlafaxine extended-release for depression following spinal cord injury: a randomized clinical trial","volume":"72","author":"Fann","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"2025120518393434000_12.12.e055800.21","doi-asserted-by":"publisher","DOI":"10.1159\/000086284"},{"key":"2025120518393434000_12.12.e055800.22","unstructured":"Trieschmann RB . Spinal cord injuries: psychological, social, and vocational rehabilitation Demos Medical Publishing; 1988."},{"key":"2025120518393434000_12.12.e055800.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90263-4"},{"key":"2025120518393434000_12.12.e055800.24","first-page":"573","article-title":"Significant events in the rehabilitation process: the spinal cord patient's point of view","volume":"59","author":"Lawson","year":"1978","journal-title":"Arch Phys Med Rehabil"},{"key":"2025120518393434000_12.12.e055800.25","first-page":"359","article-title":"Psychologic prediction of duration of inpatient spinal cord injury rehabilitation and performance of self-care","volume":"64","author":"Malec","year":"1983","journal-title":"Arch Phys Med Rehabil"},{"key":"2025120518393434000_12.12.e055800.26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00002060-199406000-00006","article-title":"Predicting depression and psychological distress in persons with spinal cord injury based on indicators of handicap","volume":"73","author":"Tate","year":"1994","journal-title":"Am J Phys Med Rehabil"},{"key":"2025120518393434000_12.12.e055800.27","first-page":"488","article-title":"Behavioral and demographic predictors of suicide after traumatic spinal cord injury","volume":"72","author":"Charlifue","year":"1991","journal-title":"Arch Phys Med Rehabil"},{"key":"2025120518393434000_12.12.e055800.28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4306\/jknpa.2020.59.3.243","article-title":"Suicidal risk in depressed patients with the treatment by antipsychotics and antidepressant compared to antidepressant monotherapy: a pilot study using psychiatric common data model","volume":"59","author":"Jaeho","year":"2020","journal-title":"Journal of Korean Neuropsychiatric Association"},{"key":"2025120518393434000_12.12.e055800.29","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2048"},{"key":"2025120518393434000_12.12.e055800.30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.15.1683"},{"key":"2025120518393434000_12.12.e055800.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.09.009"},{"key":"2025120518393434000_12.12.e055800.32","doi-asserted-by":"crossref","DOI":"10.1007\/s11920-016-0715-0","article-title":"Suicidal behavior in mood disorders: response to pharmacological treatment","volume":"18","author":"Tondo","year":"2016","journal-title":"Curr Psychiatry Rep"},{"key":"2025120518393434000_12.12.e055800.33","unstructured":"Hongsik L , Daeyeop K . Clinical neuropsychiatry. ML Communications, 2009."},{"key":"2025120518393434000_12.12.e055800.34","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"2025120518393434000_12.12.e055800.35","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"2025120518393434000_12.12.e055800.36","first-page":"489","article-title":"DSM-III: the 3d edition of the diagnostic and statistical manual of mental disorders from the American psychiatric association","volume":"142","author":"Pichot","year":"1986","journal-title":"Rev Neurol"},{"key":"2025120518393434000_12.12.e055800.37","unstructured":"KDCA. K . Evidence-based recommendations for depression in primary care; 2021."},{"key":"2025120518393434000_12.12.e055800.38","unstructured":"American Psychiatric A . Committee on N, Statistics. DSM-II : Diagnostic and statistical manual of mental disorders. 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Cochrane Handbook for systematic reviews of interventions. version 5.1.0 The Cochrane Collaboration; 2011 [Accessed Mar 2011]."},{"key":"2025120518393434000_12.12.e055800.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.09.016"},{"key":"2025120518393434000_12.12.e055800.42","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6890"},{"key":"2025120518393434000_12.12.e055800.43","doi-asserted-by":"crossref","DOI":"10.4178\/epih.e2019013","article-title":"Network meta-analysis: application and practice using R software","volume":"41","author":"Shim","year":"2019","journal-title":"Epidemiol Health"},{"key":"2025120518393434000_12.12.e055800.44","unstructured":"Dias S , Welton NJ , Sutton AJ , et al . NICE DSU technical support document 2: a generalised linear modelling framework for pairwise and network meta-analysis of randomised controlled trials, 2011. Available: www.nicedsu.org.uk [Accessed Sep 2016]."},{"key":"2025120518393434000_12.12.e055800.45","unstructured":"STATA . Available: https:\/\/www.stata.com\/features\/overview\/gelman-rubin-convergence-diagnostic\/#references"},{"key":"2025120518393434000_12.12.e055800.46","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177011136"},{"key":"2025120518393434000_12.12.e055800.47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/10618600.1998.10474787","article-title":"General methods for monitoring convergence of iterative simulations","volume":"7","author":"Brooks","year":"1998","journal-title":"Journal of Computational and Graphical Statistics"},{"key":"2025120518393434000_12.12.e055800.48","unstructured":"Deeks JJ , Higgins JPT , Altman DG . Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JPT , Thomas J , Chandler J , et al , eds. Cochrane Handbook for systematic reviews of interventions version 6.3 (updated February 2022. 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