{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:31:11Z","timestamp":1740162671736,"version":"3.37.3"},"reference-count":10,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"unspecified","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171303"],"award-info":[{"award-number":["82171303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mechanical thrombectomy (MT) had been regarded as the first-line therapy for acute ischaemic stroke patients. The sex differences in post-MT treatment outcomes were analysed by randomised controlled trial (RCT) studies with inconsistent conclusions. We suggest the results from the real-world data may differ from RCT containing studies. Therefore, the sex difference in non-clinical trial populations needs to be clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>In order to obtain relative studies comprehensively, we will search the main document databases, consisting of Web of Science, Medline in Ovid, Embase in Ovid and Cochrane Library, and trials registers, including Clinical Trails register. The clinical outcomes of real-world studies published between January 2015 and March 2022 will be included. The assessment methods of bias risk will be performed according to study type. The inclusion of studies, evaluation of risk and publication bias, data extraction will be implemented by two reviewers, respectively. The primary outcomes include successful recanalisation and 90-day favourable outcome. Secondary outcomes include vascular complication, hospital-related complications, death during hospital stay and follow-up, and intracerebral haemorrhage. The risk bias of observational studies will be evaluated by Newcastle-Ottawa Scale. I<jats:sup>2<\/jats:sup> statistic will be used to perform the assessment of study heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>With no need of ethics approval in this review, results in this review ground on public data. The results of the study will be eventually presented at international conferences or in a related journal.<\/jats:p><\/jats:sec><jats:sec><jats:title>PROSPERO registration number<\/jats:title><jats:p>CRD42021242597.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2021-056025","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T15:30:32Z","timestamp":1650036632000},"page":"e056025","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sex differences in outcomes after mechanical thrombectomy for acute ischemic stroke in the \u2018real world\u2019: protocol for a systematic review and meta-analysis study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-018X","authenticated-orcid":false,"given":"Lixin","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-5699","authenticated-orcid":false,"given":"Adam Andrew","family":"Dmytriw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-0173","authenticated-orcid":false,"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-9185","authenticated-orcid":false,"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-6295","authenticated-orcid":false,"given":"Liqun","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"2022051704442017000_12.4.e056025.1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"2022051704442017000_12.4.e056025.2","doi-asserted-by":"publisher","DOI":"10.1159\/000447331"},{"key":"2022051704442017000_12.4.e056025.3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023743"},{"key":"2022051704442017000_12.4.e056025.4","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00062-020-00983-2","article-title":"Sex differences in outcome after thrombectomy for acute ischemic stroke are explained by confounding factors","volume":"31","author":"Deb-Chatterji","year":"2021","journal-title":"Clin Neuroradiol"},{"key":"2022051704442017000_12.4.e056025.5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105240","article-title":"Sex-Related Differences after Endovascular Treatment of Acute Ischemic Stroke in the 'Real World'","volume":"29","author":"Ciardi","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2022051704442017000_12.4.e056025.6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000484098","article-title":"Is the efficacy of endovascular treatment for acute ischemic stroke sex-related","volume":"7","author":"Carvalho","year":"2018","journal-title":"Interv Neurol"},{"key":"2022051704442017000_12.4.e056025.7","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025344"},{"key":"2022051704442017000_12.4.e056025.8","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014050"},{"key":"2022051704442017000_12.4.e056025.9","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7075"},{"key":"2022051704442017000_12.4.e056025.10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014425","article-title":"Mortality risk in acute ischemic stroke patients with large vessel occlusion treated with mechanical thrombectomy","volume":"8","author":"Katsanos","year":"2019","journal-title":"J Am Heart Assoc"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-056025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T11:45:59Z","timestamp":1652787959000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-056025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,15]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bmjopen-2021-056025"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-056025","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}