{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:10:26Z","timestamp":1790691026008,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MEDITECH INFRAMED Corporation","award":["no award\/grant number"],"award-info":[{"award-number":["no award\/grant number"]}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["0620212860"],"award-info":[{"award-number":["0620212860"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,8,21]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Even though the injection of diluted vasopressin into the uterus is expected to reduce intraoperative bleeding with decreased adverse effects during robot-assisted laparoscopic myomectomy (RALM), there is a lack of relevant trials to show its effect and safety. Thus, this study was designed to compare the effect and safety of vasopressin injection on bleedings based on dilution levels of vasopressin with constant volumes during RALM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This is a randomised controlled pilot trial, where a total of 39 patients will be randomly divided into three experimental groups in a 1:1:1 ratio. All patients will be classified into the three groups based on the dilution level of vasopressin: group 1\u2014a solution prepared by mixing 20 units of vasopressin with 100\u2009mL of normal saline to make a total of 100\u2009mL; group 2\u2014a solution prepared by mixing 20 units of vasopressin with 200\u2009mL of normal saline to make a total of 100\u2009mL and group 3\u2014a solution prepared by mixing 20 units of vasopressin with 400\u2009mL of normal saline to make a total of 100\u2009mL. During RALM, we will inject diluted vasopressin at different concentrations with a total of 100\u2009mL. As the primary endpoint, estimated blood loss would be compared. As secondary endpoints, we will check the level of haemoglobin and haematocrit, operation time, amount of transfusion, and the period of hospitalisation. In addition, we will check other complications related to vasopressin injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This pilot study has been approved by the Institutional Review Board of the Seoul National University Hospital (No. H-2011-107-1174). All potential subjects will be provided written informed consent. The results of this study will be published in peer-reviewed journals and be presented at academic conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration numbers<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04874246\">NCT04874246<\/jats:ext-link>\n                      and CKCT0006225.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-056145","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T07:25:57Z","timestamp":1663399557000},"page":"e056145","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Effect and safety of diluted vasopressin injection on bleeding during robot-assisted laparoscopic myomectomy: a protocol for a randomised controlled pilot trial"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct04874246","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04874246","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-8955","authenticated-orcid":false,"given":"Eun Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chung-Ang University Hospital, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrcis and Gynecology, Seoul National University Hospital, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yup","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrcis and Gynecology, Seoul National University Hospital, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunji","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrcis and Gynecology, Seoul National University Hospital, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Won","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Dongguk University College of Medicine, Goyang, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwonhwa","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"2025121221225861000_12.9.e056145.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.09.004"},{"key":"2025121221225861000_12.9.e056145.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70445-3"},{"key":"2025121221225861000_12.9.e056145.3","first-page":"7","article-title":"Robot-Assisted laparoscopic myomectomy: current status","volume":"4","author":"Arian","year":"2017","journal-title":"Robot Surg"},{"key":"2025121221225861000_12.9.e056145.4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5468\/ogs.2018.61.1.135","article-title":"Is robot-assisted laparoscopic myomectomy limited in multiple myomas?: a feasibility for ten or more myomas","volume":"61","author":"Kim","year":"2018","journal-title":"Obstet Gynecol Sci"},{"key":"2025121221225861000_12.9.e056145.5","first-page":"363","article-title":"Vasopressin as a hemostatic in gynecologic surgery; 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