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The prevalence and incidence of dry eye are major determinants of the magnitude of economic and societal costs of the disease. This protocol proposes a systematic review and meta-analysis of the prevalence and incidence of dry eye in the USA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>Working with an information specialist, we will develop search strategies for Ovid Medline and Embase for population-based cross-sectional and cohort studies involving US-based populations that report the prevalence and\/or incidence of dry eye. We will include studies involving persons of all ages from 1 January 2010 to the current date with no language restrictions. We will also hand-search references of included studies, dry eye epidemiology-related systematic reviews, clinical practice guidelines and literature provided by agencies and organisations. Two investigators will independently screen the titles and abstracts, and then full-text reports to determine eligibility. One investigator will extract study data and perform risk of bias assessments using tools designed specifically for prevalence and incidence studies. A second investigator will verify all extracted study data and risk of bias assessments. We will assess heterogeneity, qualitatively and quantitatively. When appropriate, we will meta-analyse prevalence and incidence estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>This review does not require approval by an ethics committee because it will use published studies. We will publish our results in a peer-reviewed journal and present at relevant conferences.<\/jats:p><\/jats:sec><jats:sec><jats:title>PROSPERO registration number<\/jats:title><jats:p>CRD42021256934.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2021-056203","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T18:01:15Z","timestamp":1637690475000},"page":"e056203","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and incidence of dry eye in the USA: a systematic review protocol"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-4288","authenticated-orcid":false,"given":"Paul","family":"McCann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison G","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren G","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hauswirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristos","family":"Ifantides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hsun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J","family":"Saldanha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"2024102804522038000_11.11.e056203.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008"},{"key":"2024102804522038000_11.11.e056203.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.033"},{"key":"2024102804522038000_11.11.e056203.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00462-7"},{"key":"2024102804522038000_11.11.e056203.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.060"},{"key":"2024102804522038000_11.11.e056203.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.02.009"},{"key":"2024102804522038000_11.11.e056203.6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181f7f363"},{"key":"2024102804522038000_11.11.e056203.7","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1167\/iovs.16-19419","article-title":"Impact of dry eye disease on work productivity, and patients\" satisfaction with over-the-counter dry eye treatments","volume":"57","author":"Nichols","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024102804522038000_11.11.e056203.8","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0915"},{"key":"2024102804522038000_11.11.e056203.9","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000134183.47687.75"},{"key":"2024102804522038000_11.11.e056203.10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jtos.2015.11.002","article-title":"Economic and humanistic burden of dry eye disease in Europe, North America, and Asia: a systematic literature review","volume":"14","author":"McDonald","year":"2016","journal-title":"Ocul Surf"},{"key":"2024102804522038000_11.11.e056203.11","unstructured":"Mulcahy AW , Whaley CM , Gizaw M . 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