{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:20Z","timestamp":1790717120061,"version":"4.1.0"},"reference-count":78,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,2,23]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with metastatic non-small cell lung cancer (mNSCLC) suffer from numerous symptoms linked to disease and treatment which may further impair the patient\u2019s overall condition. In addition to its benefits on quality of life and fatigue, physical exercise may improve treatment response, notably due to its known effects on the immune system. The ERICA study is designed to assess the feasibility of a supervised acute physical exercise therapy realised immediately prior immune-chemotherapy infusion in patients with mNSCLC. Secondary objectives will examine the effects of acute exercise combined with an unsupervised home-walking programme on clinical, physical, psychosocial and biological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>ERICA is a prospective, monocentric, randomised controlled, open-label feasibility study conducted at the Centre L\u00e9on B\u00e9rard Comprehensive Cancer Center (France). Thirty patients newly diagnosed with mNSCLC will be randomised (2:1 ratio) to the \u2018exercise\u2019 or the \u2018control\u2019 group. At baseline and during the last treatment cycle, participants in both groups will receive Physical Activity recommendations, and two nutritional assessments. In the exercise group, participants will receive a 3-month programme consisting of a supervised acute physical exercise session prior to immune-chemotherapy infusion, and an unsupervised home-based walking programme with an activity tracker. The acute exercise consists of 35 min interval training at submaximal intensity scheduled to terminate 15 min prior to infusion. Clinical, physical, biological and psychosocial parameters will be assessed at baseline, 3 and 6 months after inclusion. Biological measures will include immune, inflammatory, metabolic, oxidative stress biomarkers and molecular profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      The study protocol was approved by the French ethics committee (Comit\u00e9 de protection des personnes Ile de France II, N\u00b0ID-RCB 20.09.04.65226, 8 December 2020). The study is registered on ClinicalTrials.gov (NCT number:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04676009\">NCT04676009<\/jats:ext-link>\n                      ) and is at the pre-results stage. All participants will sign an informed consent form. The findings will be disseminated in peer-reviewed journals and academic conferences.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-056819","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T12:55:54Z","timestamp":1649336154000},"page":"e056819","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of acute aerobic exercise before immunotherapy and chemotherapy infusion in patients with metastatic non-small-cell lung cancer: protocol for the ERICA feasibility trial"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct04676009","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04676009","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-269X","authenticated-orcid":false,"given":"Manon","family":"Gouez","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Environment, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"},{"name":"Inter-University Laboratory of Human Movement Biology, Universite Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"P\u00e9rol","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"P\u00e9rol","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Caux","sequence":"additional","affiliation":[{"name":"INSERM U1052, Lyon, Rh\u00f4ne-Alpes, France"},{"name":"Laboratory of Cancer Immunotherapy of LYON, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"M\u00e9n\u00e9trier-Caux","sequence":"additional","affiliation":[{"name":"INSERM U1052, Lyon, Rh\u00f4ne-Alpes, France"},{"name":"Laboratory of Cancer Immunotherapy of LYON, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Villard","sequence":"additional","affiliation":[{"name":"Inserm, U1111, CNRS UMR5308, Centre International de Recherche en Infectiologie, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Walzer","sequence":"additional","affiliation":[{"name":"Inserm, U1111, CNRS UMR5308, Centre International de Recherche en Infectiologie, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-5390","authenticated-orcid":false,"given":"Lidia","family":"Delrieu","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"},{"name":"Inter-University Laboratory of Human Movement Biology, Universite Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Saintigny","sequence":"additional","affiliation":[{"name":"INSERM U1052, Lyon, Rh\u00f4ne-Alpes, France"},{"name":"Department of Translational Medicine, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marijnen","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pialoux","sequence":"additional","affiliation":[{"name":"Inter-University Laboratory of Human Movement Biology, Universite Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, Centre L\u00e9on B\u00e9rard, Lyon, Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"2025121422485472000_12.4.e056819.1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy275"},{"key":"2025121422485472000_12.4.e056819.2","unstructured":"ASCO . 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