{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:08:01Z","timestamp":1791288481481,"version":"4.3.0"},"reference-count":21,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,6,14]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the clinical benefit of endovascular revascularisation (EVR) in octogenarian (aged \u226580 years) patients with lower extremity artery disease (LEAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective single-centre study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University hospital with a specialised centre for vascular medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>681 LEAD patients undergoing EVR between 2010 and 2016 were stratified by age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>Technical success, complications and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 172 (25.3%) octogenarian and 509 (74.7%) non-octogenarian patients. Despite higher LEAD stages and complexity of EVR in octogenarians, primary technical success rate (79% octogenarians vs 86% non-octogenarians, p=0.006) and 1-year survival (87% vs 96%, p&lt;0.001) were overall on high levels. Especially for the octogenarians, 1-year survival depends on the presence of chronic limb-threatening ischaemia (CLTI) (octogenarians: non-CLTI 98%; CLTI 79% p&lt;0.001 vs non-octogenarians: non-CLTI 99%; CLTI 91%, p&lt;0.001). In octogenarians, female sex (HR 0.45; 95% CI (0.24 to 0.86); p=0.015), the intake of statins (HR 0.34; 95% CI 0.19 to 0.65; p=0.001) and platelet aggregation inhibitors (HR 0.10; 95% CI 0.02 to 0.45; p=0.003) were independently associated with improved survival after EVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EVR can be performed safely and with sustained clinical benefit also in octogenarian patients with LEAD. After-care including medical adherence is of particular importance to improve long-term survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-057630","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T12:18:37Z","timestamp":1659356317000},"page":"e057630","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Outcome in octogenarian patients with lower extremity artery disease after endovascular revascularisation: a retrospective single-centre cohort study using in-patient data"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1374-9275","authenticated-orcid":false,"given":"Antonia","family":"Lakomek","sequence":"first","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"K\u00f6ppe","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Barenbrock","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Volkery","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik","family":"Feld","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Makowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-5117","authenticated-orcid":false,"given":"Christiane","family":"Engelbertz","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser M","family":"Malyar","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Freisinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Nordrhein-Westfalen, 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