{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:40:50Z","timestamp":1764999650126,"version":"3.46.0"},"reference-count":23,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research Foundation of Central Region Denmark","award":["A2682"],"award-info":[{"award-number":["A2682"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordic Foundation","doi-asserted-by":"crossref","award":["NNF19OC0057545"],"award-info":[{"award-number":["NNF19OC0057545"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008628","name":"Institut for Klinisk Medicin, Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,3,30]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Obesity is associated with many pregnancy complications, including both fetal macrosomia and prolonged labour. As a result, there is often also an increased risk of caesarean section. In other settings, labour induction near to term reduces adverse outcomes such as stillbirth and birth injury, without causing more caesarean deliveries. It has been suggested that induction will reduce adverse events in this setting too, but there have been no trials and the effect on caesarean section is unknown. The objective of this study is to compare induction of labour in gestational week 39 with expectant management on the risk of caesarean section in women with body mass index \u226530\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      An open label randomised controlled multicentre trial are conducted at Danish delivery departments with an in-house neonatal intensive care unit. Recruitment started October 2020. A total of 1900\u2009women with a prepregnancy body mass index \u226530\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      are randomised in a 1:1 ratio to either labour induction at 39 weeks and 0 to 3\u2009days of gestation or to expectant management; that is, waiting for spontaneous labour onset or induction if medically indicated. The primary outcome is caesarean section. Data will be analysed according to intention-to-treat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The Central Denmark Region Committee on Biomedical Research Ethics approved the study. The study is conducted in accordance with the ethical principles outlined in the latest version of the \u2018Declaration of Helsinki\u2019 and the \u2018Guideline for Good Clinical Practice\u2019 related to experiments on humans. The trial findings will be disseminated to participants, clinicians, commissioning groups and via peer-reviewed publications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04603859\">NCT04603859<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-057688","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T08:08:46Z","timestamp":1652774926000},"page":"e057688","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Induction of labour at 39 weeks versus expectant management in low-risk obese women: study protocol for a randomised controlled study"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct04603859","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-4576","authenticated-orcid":false,"given":"Lise Qvirin","family":"Krogh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidsel","family":"Boie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Randers Regional Hospital, Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-8294","authenticated-orcid":false,"given":"Tine Brink","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-6876","authenticated-orcid":false,"given":"Jim","family":"Thornton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Fuglsang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Glavind","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"2025120521381010000_12.4.e057688.1","unstructured":"WHO . 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