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This study aimed to explore FSW\u2019s acceptability and preferences for oral pills, long-acting (LA) injectable and vaginal ring PrEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Sequential, explanatory, mixed methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Iringa, Tanzania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>FSW aged above 18 were recruited from sex work venues using time-location sampling (n=496); HIV-uninfected (n=293) were included in this analysis. Subsequently, survey participants were recruited for in-depth interviews (n=10) and two focus group discussions (n=20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Primary outcome measures<\/jats:title><jats:p>(1) Acceptability of PrEP (Do you personally think it would be worth it to you to take ART if it could prevent HIV?: yes\/no) and (2) preference for LA injectable versus oral pills (If you personally were going to take ART to prevent HIV infection, would you prefer to take it in the form of a daily pill or an injection once every 3 months? Injection\/pill).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants were (92%) unaware of PrEP but 58% thought it would be worth it to personally take PrEP. Acceptability of PrEP was significantly associated with higher social cohesion (aOR 2.12; 95%\u2009CI 1.29 to 3.50) and STI symptoms in the past 6 months (aOR 2.52; 95%\u2009CI 1.38 to 4.62). Most (88%) preferred LA vs oral PrEP. Qualitative findings revealed generally positive reactions to all types of PrEP, and they were viewed as a welcome backup to condoms. Participants had concerns about pills (burden of daily use, stigma from clients), and the vaginal ring (fear of client noticing and becoming suspicious, fear of infertility) and overall preferred LA-PrEP (less frequent use, easy to hide, belief in higher efficacy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Offering multiple formulations of PrEP within the context of community-driven HIV prevention interventions among FSW may facilitate increased uptake and adherence. LA injectable PrEP may be a particularly preferred formulation among FSW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02281578\">NCT02281578<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2021-058611","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T15:05:32Z","timestamp":1660748732000},"page":"e058611","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Acceptability of multiple modalities of pre-exposure prophylaxis (PrEP) among female sex workers in Tanzania: a mixed-methods study"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct02281578","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-3091","authenticated-orcid":false,"given":"S Wilson","family":"Beckham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mantsios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noya","family":"Galai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Likindikoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Mbwambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna","family":"Kerrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"2022081708051077000_12.8.e058611.1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0140-6736(18)31439-9","article-title":"The global response and unmet actions for HIV and sex workers","volume":"392","author":"Shannon","year":"2018","journal-title":"Lancet"},{"key":"2022081708051077000_12.8.e058611.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063476"},{"key":"2022081708051077000_12.8.e058611.3","doi-asserted-by":"crossref","DOI":"10.7448\/IAS.16.1.17980","article-title":"Priority interventions to reduce HIV transmission in sex work settings in sub-Saharan Africa and delivery of these services","volume":"16","author":"Chersich","year":"2013","journal-title":"J Int AIDS Soc"},{"key":"2022081708051077000_12.8.e058611.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1728-4465.2015.00015.x"},{"key":"2022081708051077000_12.8.e058611.5","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2014.0077"},{"key":"2022081708051077000_12.8.e058611.6","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001145"},{"key":"2022081708051077000_12.8.e058611.7","doi-asserted-by":"crossref","DOI":"10.7448\/IAS.19.7.21104","article-title":"Prep as a feature in the optimal landscape of combination HIV prevention in sub-Saharan Africa","volume":"19","author":"McGillen","year":"2016","journal-title":"J Int AIDS Soc"},{"key":"2022081708051077000_12.8.e058611.8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.7448\/IAS.19.1.20942","article-title":"Potential impact of pre-exposure prophylaxis for female sex workers and men who have sex with men in Bangalore, India: a mathematical modelling study","volume":"19","author":"Mitchell","year":"2016","journal-title":"J Int AIDS Soc"},{"key":"2022081708051077000_12.8.e058611.9"},{"key":"2022081708051077000_12.8.e058611.10","unstructured":"Murray MI , Markowitz M , Frank I . 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