{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:18:56Z","timestamp":1774379936064,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,5,25]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore the potential use of body mass index (BMI), proteinuria and total lymphocyte count changes in predicting immunological and virological response in individuals with HIV initiated on antiretroviral treatment (ART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three urban HIV care and treatment centres in Dar es Salaam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals with HIV initiating ART.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>HIV viral load \u22651000 copies\/mL (viral non-suppression) at 6\u2009months after ART initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 215 (out of 220 enrolled) participants who returned for evaluation at 6\u2009months, 147 (66.8%) were women. At 6\u2009months of follow-up, 89.4% (76\/85) of participants with sustained weight gain were virally suppressed compared with 31.8% (7\/22) with sustained loss, p&lt;0.001. In participants who were lymphopaenic at baseline, an increase to normal total lymphocyte counts at 6\u2009months was associated with an increase in CD4 count compared with participants who remained lymphopaenic, 96.2% (50\/52) versus 54.8% (17\/31), p&lt;0.001. At baseline, 50.0% (110\/220) had proteinuria. In participants without proteinuria from baseline to 6\u2009months, 89.8% (79\/88) were virally suppressed compared with participants with proteinuria at baseline and\/or 3\u2009months, 85.6% (77\/90), those with persistent proteinuria, 30.8% (8\/26), and proteinuria at 6\u2009months only, 45.5% (5\/11), p&lt;0.001. In modified Poisson regression, the independent predictors other than CD4 cell counts for viral non-suppression at 6\u2009months among individuals with HIV initiating on ART were BMI loss &gt;5% from baseline to 6\u2009months (adjusted RR 2.73, 95%\u2009CI (1.36 to 5.47)), lymphopaenia at 6\u2009months (adjusted RR=4.54, 95%\u2009CI (2.19 to 9.39)) and proteinuria at 6\u2009months (adjusted RR=2.63, 95%\u2009CI (1.25 to 5.54)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Change in BMI, total lymphocyte count and presence of proteinuria can monitor and predict ART response and may be particularly helpful in settings when CD4 counts and viral load monitoring are unavailable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-059193","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T11:12:59Z","timestamp":1654686779000},"page":"e059193","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Body mass index, proteinuria and total lymphocyte counts in predicting treatment responses among ART na\u00efve individuals with HIV initiated on antiretroviral treatment in Dar es Salaam, Tanzania, 2019: a cohort study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-2755","authenticated-orcid":false,"given":"Patricia","family":"Munseri","sequence":"first","affiliation":[{"name":"Internal Medicine, Muhimbili University of Health and Allied Sciences School of Medicine, Dar es Salaam, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazaro","family":"Jassely","sequence":"additional","affiliation":[{"name":"Internal Medicine, Muhimbili University of Health and Allied Sciences School of Medicine, Dar es Salaam, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-1684","authenticated-orcid":false,"given":"Basil","family":"Tumaini","sequence":"additional","affiliation":[{"name":"Internal Medicine, Muhimbili University of Health and Allied Sciences School of Medicine, Dar es Salaam, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Hertzmark","sequence":"additional","affiliation":[{"name":"Global Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"2025121508141847000_12.6.e059193.1","unstructured":"UNAIDS . 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