{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:28:25Z","timestamp":1765596505341,"version":"3.48.0"},"reference-count":15,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"unspecified","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,3,22]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction and objective<\/jats:title>\n                    <jats:p>Research activity was impacted by the novel COVID-19 pandemic, the PERCEPT myeloma trial was no exception. This pilot randomised trial delivered a face-to-face exercise intervention prior to and during autologous stem cell transplantation (ASCT) in myeloma patients, as a consequence of COVID-19 it required significant adaptions to continue. This brief communication describes how the previously published study protocol was adapted for virtual delivery. In addition, we highlight the challenge of continuing the study which was embedded within a clinical pathway also impacted by the pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The original trial protocol was amended and continued to recruit and deliver an exercise prehabilitation intervention virtually. Continued delivery of the intervention was deemed important to participants already enrolled within the trial and the adapted virtual version of the trial was acceptable to the research ethics committee as well as participants. Development of effective, remotely delivered rehabilitation and physical activity programmes are likely to benefit people living with myeloma. The COVID-19 pandemic provided an opportunity to explore the feasibility of a virtual programme for ASCT recipients, however, continued changes to the clinical pathway within which the study was embedded posed the greatest challenge and ultimately led to early termination of recruitment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"ISRCTN15875290\">ISRCTN15875290; pre-results<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-059516","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:17:33Z","timestamp":1649420253000},"page":"e059516","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Adaptation of the PERCEPT myeloma prehabilitation trial to virtual delivery: changes in response to the COVID-19 pandemic"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"isrctn15875290","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-2540","authenticated-orcid":false,"given":"Orla","family":"McCourt","sequence":"first","affiliation":[{"name":"Therapies & Rehabilitation, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"Research Department of Haematology, Cancer Institute, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Fisher","sequence":"additional","affiliation":[{"name":"Research Department of Behavoural Science and Health, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gita","family":"Ramdharry","sequence":"additional","affiliation":[{"name":"Queen Square Centre for Neuromuscular Diseases, National Hosital for Neurology and Neurosurger, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L","family":"Roberts","sequence":"additional","affiliation":[{"name":"Research Department of Behavoural Science and Health, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Land","sequence":"additional","affiliation":[{"name":"Research Department of Behavoural Science and Health, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Rabin","sequence":"additional","affiliation":[{"name":"Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Rowe","sequence":"additional","affiliation":[{"name":"Research Department of Haematology, Cancer Institute, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwee","family":"Yong","sequence":"additional","affiliation":[{"name":"Research Department of Haematology, Cancer Institute, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"2025121219271671000_12.4.e059516.1","doi-asserted-by":"publisher","DOI":"10.3126\/nje.v10i3.31622"},{"key":"2025121219271671000_12.4.e059516.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2020-000985"},{"key":"2025121219271671000_12.4.e059516.3","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04711-6"},{"key":"2025121219271671000_12.4.e059516.4","unstructured":"NHS Providers . Confronting coronavirus in the NHS: the story so far 2020."},{"key":"2025121219271671000_12.4.e059516.5","unstructured":"Dunn P et al . COVID-19 policy tracker 2020."},{"key":"2025121219271671000_12.4.e059516.6","first-page":"e224","article-title":"Assessing the impact of lockdown: fresh challenges for the care of haematology patients in the COVID-19 pandemic","volume":"189","author":"Willan","year":"2020","journal-title":"Br J Haematol"},{"key":"2025121219271671000_12.4.e059516.7","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2020-001359"},{"key":"2025121219271671000_12.4.e059516.8","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-021-05700-z","article-title":"Adapting the design of a web-based decision support clinical trial during the COVID-19 pandemic","volume":"22","author":"Meline","year":"2021","journal-title":"Trials"},{"key":"2025121219271671000_12.4.e059516.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-033176"},{"key":"2025121219271671000_12.4.e059516.10","doi-asserted-by":"crossref","DOI":"10.1007\/s10916-020-01593-8","article-title":"Using telehealth cardiopulmonary rehabilitation during the COVID-19 pandemic","volume":"44","author":"Bryant","year":"2020","journal-title":"J Med Syst"},{"key":"2025121219271671000_12.4.e059516.11","unstructured":"HSE National Clinical Programme Respiratory . Guidance for setting up virtual pulmonary rehabilitation for asthma and COPD during the Covid 19 pandemic. Ireland, 2020."},{"key":"2025121219271671000_12.4.e059516.12","unstructured":"Agency for Clinical Innovation . Delivering pulmonary rehabilitation via telehealth during COVID-19. Australia, 2020."},{"key":"2025121219271671000_12.4.e059516.13","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.1.M28"},{"key":"2025121219271671000_12.4.e059516.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(03)00082-7"},{"key":"2025121219271671000_12.4.e059516.15","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1249\/MSS.0000000000002276","article-title":"Cardiorespiratory response during the 1-min Sit-to-Stand test in chronic obstructive pulmonary disease","volume":"52","author":"Gephine","year":"2020","journal-title":"Med Sci Sports Exerc"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2021-059516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:27:23Z","timestamp":1765596443000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2021-059516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,8]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bmjopen-2021-059516"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2021-059516","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}