{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:31:44Z","timestamp":1767853904155,"version":"3.49.0"},"reference-count":43,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"unspecified","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC1000204"],"award-info":[{"award-number":["2016YFC1000204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,6,2]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Anhui Maternal\u2013Child Health Study (AMCHS) aims to examine determinants of reproduction, pregnancy and postpartum maternal and child health outcomes in Chinese women who received assisted reproductive technology (ART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design and participants<\/jats:title>\n                    <jats:p>AMCHS is an ongoing cohort study starting from May 2017. AMCHS recruits participants from all couples who sought ART treatment in the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. The participants are interviewed to document baseline sociodemography, lifestyles, dietary intake and environmental exposure. Their clinical characteristics are obtained from hospital records. Samples of blood, follicular fluid and semen are collected at the clinic. Participants receive a standard long pituitary downregulation or a short protocol with an antagonist for the treatment. They are followed up from preconception to delivery, or discontinuation of ART treatment. Details of their children\u2019s health are documented through a questionnaire focusing on developmental status and anthropometry measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>Until April 2021, AMCHS had recruited 2042 couples in the study. 111\u2009women withdrew from the study and 19 failed to retrieve oocytes. Among the 1475 confirmed pregnancies, 146 had miscarriages or terminated their pregnancies, 9 had stillbirths and 263 were ongoing pregnancies. The implantation failure increased with maternal age; adjusted OR was 1.43 (95% CI 1.16 to 1.77) in the age of 31\u201335 years, 1.97 (95% CI 1.46 to 2.66) in 35\u201339 years and 6.52 (95% CI 3.35 to 12.68) in \u226540 years compared with those aged 20\u201330 years. Among the 1057 couples with successful ART who were followed up for delivering babies, 576 had their children examined at age 30\u201342\u2009days, 459 at 6 months and 375 at 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The AMCHS will identify comprehensive risk factors for poor ART outcomes and explore potential interaction effects of multiple factors including sociopsychological aspects of environmental exposure, dietary intake and genetics on maternal and child health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-060091","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:28Z","timestamp":1656460828000},"page":"e060091","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Cohort profile: Anhui Maternal\u2013Child Health Study in China"],"prefix":"10.1136","volume":"12","author":[{"given":"Jiaqian","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-6774","authenticated-orcid":false,"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Anhui Medical University, Hefei, China"},{"name":"National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Liang","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, China"},{"name":"Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Peng","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiju","family":"Zhou","sequence":"additional","affiliation":[{"name":"Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK"},{"name":"The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit","family":"Khutan","sequence":"additional","affiliation":[{"name":"Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Biao","family":"Tao","sequence":"additional","affiliation":[{"name":"Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoling","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Health and Social Care Improvement, University of Wolverhampton, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"2025121600072848000_12.6.e060091.1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1089\/jwh.2015.5355","article-title":"CDC releases a national public health action plan for the detection, prevention, and management of infertility","volume":"24","author":"Warner","year":"2015","journal-title":"J Womens Health"},{"key":"2025121600072848000_12.6.e060091.2","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.18632\/aging.102497","article-title":"Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990-2017: results from a global burden of disease study, 2017","volume":"11","author":"Sun","year":"2019","journal-title":"Aging"},{"key":"2025121600072848000_12.6.e060091.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"2025121600072848000_12.6.e060091.4","unstructured":"WHO . 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