{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:36:51Z","timestamp":1760834211292,"version":"build-2065373602"},"reference-count":9,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"unspecified","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81960219"],"award-info":[{"award-number":["81960219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical research project of the Second Affiliated Hospital of Kunming Medical University","award":["2020ynlc009","ynIIT2021006"],"award-info":[{"award-number":["2020ynlc009","ynIIT2021006"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,10,10]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Mechanical thrombectomy (MT) using stent retrievers or a direct aspiration first-pass technique has proven to yield better results over intravenous thrombolysis in treating acute ischaemic stroke caused by large vessel occlusion (LVO). However, the treatment of intracranial atherosclerotic stenosis-related LVO remains unclear and has been a critical problem in daily clinical practice, as it can cause a relatively high failure rate for MT. Whether direct angioplasty and\/or stenting is clinically feasible and shows advantage in reducing delay to revascularisation with better functional outcome compared with MT with rescue angioplasty and\/or stenting remains unclear. This study seeks to provide direct and practical clinical evidence for clinicians.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The main databases of PubMed, the Cochrane library, Embase and Web of Science will be screened for related studies published after1 January 2015. Primary outcomes include successful recanalisation and 90-day favourable outcome. Secondary outcomes include puncture to revascularisation time, vascular complication (perforation, dissection and vasospasm), intracerebral haemorrhage, hospital-related complications and 90-day mortality. The Newcastle-Ottawa Scale will be adopted to assess risk bias of observational studies. The <jats:italic>I<\/jats:italic>\n                     <jats:sup>2<\/jats:sup> statistic will be used to assess heterogeneity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>No primary data of patients are needed. Therefore, ethics approval is unnecessary. The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD42021268061.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-060136","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T12:35:34Z","timestamp":1667219734000},"page":"e060136","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical thrombectomy first versus direct angioplasty or stenting for the treatment of intracranial atherosclerotic stenosis-related large vessel occlusion: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"12","author":[{"given":"Xiaoli","family":"Min","sequence":"first","affiliation":[{"name":"Department of Cerebrovascular Diseases, The Second Affiliated Hospital, Kunming Medical University, Kunming, China"},{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Department of Neurosurgery, Liaocheng Brain Hospital, Liaocheng, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengxiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Department of Neurosurgery, China International Neuroscience Institute, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bazhong Central Hospital, 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