{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:14:09Z","timestamp":1777029249928,"version":"3.51.4"},"reference-count":33,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006387","name":"Leenaards Foundation","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006392","name":"Lausanne University Hospital","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100006392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Emergency Department","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Early identification of SARS-CoV-2 infection is important to guide quarantine and reduce transmission. This study evaluates the diagnostic performance of lung ultrasound (LUS), an affordable, consumable-free point-of-care tool, for COVID-19 screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting and participants<\/jats:title>\n                    <jats:p>This prospective observational cohort included adults presenting with cough and\/or dyspnoea at a SARS-CoV-2 screening centre of Lausanne University Hospital between 31 March and 8 May 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Investigators recorded standardised LUS images and videos in 10 lung zones per patient. Two blinded independent experts reviewed LUS recording and classified abnormal findings according to prespecified criteria to investigate their predictive value to diagnose SARS-CoV-2 infection according to PCR on nasopharyngeal swabs (COVID-19 positive vs COVID-19 negative).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>We finally combined LUS and clinical findings to derive a multivariate logistic regression diagnostic score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 134 included patients, 23% (n=30\/134) were COVID-19 positive and 77% (n=103\/134) were COVID-19 negative; 85%, (n=114\/134) cases were previously healthy healthcare workers presenting within 2\u20135\u2009days of symptom onset (IQR). Abnormal LUS findings were significantly more frequent in COVID-19 positive compared with COVID-19 negative (45% vs 26%, p=0.045) and mostly consisted of focal pathologic B lines. Combining clinical findings in a multivariate logistic regression score had an area under the receiver operating curve of 80.3% to detect COVID-19, and slightly improved to 84.5% with the addition of LUS features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>COVID-19-positive patients are significantly more likely to have lung pathology by LUS. However, LUS has an insufficient sensitivity and is not an appropriate screening tool in outpatients. LUS only adds little value to clinical features alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-060181","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:50:20Z","timestamp":1656067820000},"page":"e060181","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-071X","authenticated-orcid":false,"given":"Sim\u00e9on","family":"Schaad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brahier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary-Anne","family":"Hartley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Baptiste","family":"Cordonnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanguy","family":"Espejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Pantet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-1625","authenticated-orcid":false,"given":"Olivier","family":"Hugli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Nicolas","family":"Carron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Meuwly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Boillat-Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"2022070101300844000_12.6.e060181.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"2022070101300844000_12.6.e060181.2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200642"},{"key":"2022070101300844000_12.6.e060181.3","article-title":"Chest CT findings in cases from the Cruise Ship Diamond Princess with Coronavirus Disease (COVID-19)","volume":"2","author":"Inui","year":"2020","journal-title":"Radiol Cardiothorac Imaging"},{"key":"2022070101300844000_12.6.e060181.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30086-4"},{"key":"2022070101300844000_12.6.e060181.5","article-title":"Thoracic imaging tests for the diagnosis of COVID-19","volume":"11","author":"Islam","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"2022070101300844000_12.6.e060181.6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/MEJ.0000000000000517","article-title":"Lung ultrasound in diagnosing pneumonia in the emergency department: a systematic review and meta-analysis","volume":"25","author":"Orso","year":"2018","journal-title":"Eur J Emerg Med"},{"key":"2022070101300844000_12.6.e060181.7","doi-asserted-by":"crossref","unstructured":"Peng Q-Y , Wang X-T , Zhang L-N . 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