{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T13:01:03Z","timestamp":1765890063699,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["19\/690"],"award-info":[{"award-number":["19\/690"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,6,27]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Routinely collected data can be linked to research data to create a rich dataset and inform practice. However, consent is normally required to link identifiable data. Reported rates of consent to data linkage for children ranged from 21% to 96%, but no studies have investigated different approaches to seeking consent for data linkage for school-age children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>A<\/jats:italic>\n                      pproaches to\n                      <jats:italic>Co<\/jats:italic>\n                      nsent for\n                      <jats:italic>R<\/jats:italic>\n                      outine Data Linkage in\n                      <jats:italic>N<\/jats:italic>\n                      eonatal Follow-up (ACORN) trial is a 2\u00d72 factorial randomised trial to assess whether, for children who participated in neonatal randomised trials (pre-hypoglycaemia Prevention with Oral Dextrose Gel (hPOD), hPOD and The Impact of Protein Intravenous Nutrition on Development in Extremely Low Birth Weight Babies (ProVIDe)) and are approached to participate in an in-person assessment at 6\u20137 years of age, parental consent to data linkage is higher if consent is sought (1) after the in-person assessment (delayed) or concurrently and (2) for health and education data combined or separately. The primary outcomes will be rates of consent to linkage of (1) either health or education data and (2) both health and education data. A pilot study indicates the potentially available cohort size of 2110 (80% follow-up of the neonatal trial cohorts) would be adequate to detect an absolute difference of 6%\u20135%\u20134% from a baseline consent rate of 70%\u201385%\u201390%,\u2009respectively (2-tailed alpha 0.05, 90% power). With at least 1136 participants, the ACORN trial would have 90% power to detect an absolute difference of 5% in the primary outcome for each factor, assuming a consent rate of 90% in the control groups and alpha 0.05. Data are categorical and will be presented as number and per cent. The effects of factors will be tested using generalised linear models and presented as ORs and 95% CIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval by the New Zealand Health and Disability Ethics Committee (19\/STH\/202). Dissemination will be via peer-reviewed publications, scientific meetings, educational sessions and public fora.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12621000571875 (Australian New Zealand Clinical Trials Registry).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-060476","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T12:04:03Z","timestamp":1657713843000},"page":"e060476","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Different\n                    <i>A<\/i>\n                    pproaches to requesting\n                    <i>Co<\/i>\n                    nsent for\n                    <i>R<\/i>\n                    outine data linkage in\n                    <i>N<\/i>\n                    eonatal follow-up (ACORN): protocol for a 2\u00d72 factorial randomised trial"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-1422","authenticated-orcid":false,"given":"Jane E","family":"Harding","sequence":"first","affiliation":[{"name":"Liggins Institute, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-2975","authenticated-orcid":false,"given":"Aakash Bajirao","family":"Rajay","sequence":"additional","affiliation":[{"name":"Liggins Institute, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0874-6654","authenticated-orcid":false,"given":"Jane Marie","family":"Alsweiler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Child and Youth Health, The University of Auckland, Auckland, New 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