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Respiratory physiotherapy may improve lung function in this population. This study aims to investigate the effects of respiratory physiotherapy on lung function, cough efficacy and functional status of patients with ALS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>A protocol was published on the International prospective register of systematic reviews (PROSPERO). The research will cover randomised controlled trials, with no language or publication date restriction, available in the following databases: MEDLINE\/PubMed, EMBASE, Cochrane Library, Web of Science and Physiotherapy Evidence Database. The research question will be answered using a search strategy adapted for each database. Searches in databases will be conducted from January 2021 to December 2022. Two authors using the Cochrane risk of bias tool for randomised trials V.2 and Grading of Recommendations, Assessment, Development and Evaluations, respectively, will assess risk of bias and quality of evidence independently. According to the results obtained, data will be reported as a meta-analysis or a narrative report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>No previous ethical approval is required for this publication since data used are already published. Results of this review will be disclosed via peer-reviewed publications and conference presentations.<\/jats:p><\/jats:sec><jats:sec><jats:title>PROSPERO registration number<\/jats:title><jats:p>CRD42021251842.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2022-061624","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T15:50:52Z","timestamp":1653925852000},"page":"e061624","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of respiratory physiotherapy in patients with amyotrophic lateral sclerosis: protocol for a systematic review of randomised controlled trials"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-1096","authenticated-orcid":false,"given":"Karen","family":"Pondofe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Aline","family":"Marcelino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Souza","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Torres-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Vera-Uribe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme AF","family":"Fregonezi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-9364","authenticated-orcid":false,"given":"Vanessa R","family":"Resqueti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"2024032108200743000_12.5.e061624.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02717.x"},{"key":"2024032108200743000_12.5.e061624.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"2024032108200743000_12.5.e061624.3","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201506-375CC"},{"key":"2024032108200743000_12.5.e061624.4","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.apmr.2017.04.015","article-title":"Effects of air stacking maneuver on cough peak flow and chest wall compartmental volumes of subjects with amyotrophic lateral sclerosis","volume":"98","author":"Sarmento","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"key":"2024032108200743000_12.5.e061624.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.06.035"},{"key":"2024032108200743000_12.5.e061624.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-314OC"},{"key":"2024032108200743000_12.5.e061624.7","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1212\/WNL.0b013e3181c1df1e","article-title":"Lower serum lipid levels are related to respiratory impairment in patients with ALS","volume":"73","author":"Chi\u00f2","year":"2009","journal-title":"Neurology"},{"key":"2024032108200743000_12.5.e061624.8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/17482968.2011.626052","article-title":"Respiratory exercise in amyotrophic lateral sclerosis","volume":"13","author":"Pinto","year":"2012","journal-title":"Amyotrophic Lateral Sclerosis"},{"key":"2024032108200743000_12.5.e061624.9","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06827"},{"key":"2024032108200743000_12.5.e061624.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2206020"},{"key":"2024032108200743000_12.5.e061624.11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2952G"},{"key":"2024032108200743000_12.5.e061624.12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.213157"},{"key":"2024032108200743000_12.5.e061624.13","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.012716"},{"key":"2024032108200743000_12.5.e061624.14","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000437305.37850.f9"},{"key":"2024032108200743000_12.5.e061624.15","unstructured":"National Institute for Health and Care Excellence . 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