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The secondary outcomes included other measures of knee pain, physical function, quality of life, participant-perceived change in pain and function, and physical activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We planned to recruit 110 participants (55 per arm) but ceased recruitment at 40 (n=18 motion control shoes, n=22 neutral shoes) due to COVID-19-related impacts. All 40 participants completed 6-month outcomes. There was no evidence that motion control shoes were superior to neutral shoes for the primary outcome of pain (mean between-group difference 0.4 NRS units, 95%\u2009CI \u22121.0 to 1.7) nor for any secondary outcome. The number of participants experiencing any adverse events was similar between groups (motion control shoes: n=5, 28%; neutral shoes: n=4, 18.2%) and were minor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Motion control shoes were not superior to neutral shoes in improving knee pain on walking in symptomatic radiographic lateral tibiofemoral joint OA. Further research is needed to identify effective treatments in this important but under-researched knee OA subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12618001864213.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-061627","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:21:48Z","timestamp":1663978908000},"page":"e061627","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of motion control versus neutral walking footwear on pain associated with lateral tibiofemoral joint osteoarthritis: a comparative effectiveness randomised clinical trial"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-6129","authenticated-orcid":false,"given":"Kade L","family":"Paterson","sequence":"first","affiliation":[{"name":"Centre for Health, Exercise and Sports Medicine, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L","family":"Bennell","sequence":"additional","affiliation":[{"name":"Centre for Health, Exercise and Sports Medicine, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben R","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Centre for Health, Exercise and Sports Medicine, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny K","family":"Campbell","sequence":"additional","affiliation":[{"name":"Centre for Health, Exercise and Sports Medicine, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"McManus","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-8450","authenticated-orcid":false,"given":"Karen E","family":"Lamb","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Melbourne - Parkville Campus, Melbourne, Victoria, Australia"},{"name":"Methods and Implementation Support for Clinical Health research platform, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6368-9456","authenticated-orcid":false,"given":"Rana S","family":"Hinman","sequence":"additional","affiliation":[{"name":"Centre for Health, Exercise and Sports Medicine, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"2025121403121818000_12.9.e061627.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"2025121403121818000_12.9.e061627.2","unstructured":"National Clinical Guideline Centre . 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