{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:58:39Z","timestamp":1765731519002,"version":"3.48.0"},"reference-count":40,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1G1A11003"],"award-info":[{"award-number":["NRF-2019R1G1A11003"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,6,6]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) generally requires lifelong treatment; however, its medication complexity might affect non-adherence. Pharmacist-led telehealth services were as effective as face-to-face services and reduced potential side effects in outpatients with chronic diseases. This study aims to analyse the effect of a telepharmacy service with a customised mobile device in comparison with the usual pharmacist service on the humanistic and clinical outcomes in patients with RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The study is designed as a prospective, randomised, open-label, and controlled trial to compare the humanistic and clinical outcomes of the pharmaceutical care service with monthly telecommunications and a customised mobile application (telepharmacy care group) against the usual service by community pharmacists (usual care group) in 256 patients with RA and prescribed at least one of the disease-modifying antirheumatic drugs. Participants will be recruited from a tertiary hospital in Republic of Korea with written informed consent. The primary outcome will be the changes in health-related quality of life as measured by the Korean version of the EuroQoL\u2019s five-dimensional questionnaire at 6 months compared with baseline. The secondary outcomes will be the changes in the following: scores of the Korean version of the Compliance Questionnaire-Rheumatology and medication knowledge at 3 and 6 months compared with baseline; scores of the Korean version of the Pharmacy Service Questionnaire at 6 months compared with baseline; clinical parameters such as erythrocyte sedimentation rate, C reactive protein level, and pain score at 3 and 6 months compared with baseline; frequency of acute care utilisation over 6 months. Analysis will be carried out with intent-to-treat and per-protocol principles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study protocol was reviewed and approved by the Institutional Review Board (IRB) of Daegu Catholic University Medical Center (IRB no. CR-21-082-L, 14 July 2021). The study findings will be published in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>KCT0006508.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-061917","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T11:26:54Z","timestamp":1655810814000},"page":"e061917","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of a pharmaceutical care service for patients with rheumatoid arthritis using a customised mobile device (the PROUD trial): study protocol for a randomised controlled trial"],"prefix":"10.1136","volume":"12","author":[{"given":"Ji-Eun","family":"Park","sequence":"first","affiliation":[{"name":"College of Pharmacy, Daegu Catholic University, Gyeongsan, South Korea"},{"name":"Department of Pharmacy, Daegu Catholic University Medical Center, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Daegu Catholic University Medical Center, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Kyung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Daegu Catholic University Medical Center, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwajeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Yoon","family":"Choe","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-4052","authenticated-orcid":false,"given":"Yun-Kyoung","family":"Song","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Daegu Catholic University, Gyeongsan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"2025121408554686000_12.6.e061917.1","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2025121408554686000_12.6.e061917.2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216655"},{"key":"2025121408554686000_12.6.e061917.3","unstructured":"Health Insurance Review & Assessment Service . 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