{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:17:59Z","timestamp":1777976279068,"version":"3.51.4"},"reference-count":49,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Clinical Research Plan of SHDC","award":["SHDC2020CR2052B"],"award-info":[{"award-number":["SHDC2020CR2052B"]}]},{"name":"National Key Research and Development Program of China","award":["2016YFC0105409"],"award-info":[{"award-number":["2016YFC0105409"]}]},{"name":"Scientific and Technological Innovation Action Plan of Shanghai Science and Technology Committee","award":["19411950900"],"award-info":[{"award-number":["19411950900"]}]},{"name":"Scientific and Technological Innovation Action Plan of Shanghai Science and Technology Committee","award":["19411950901"],"award-info":[{"award-number":["19411950901"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,8,9]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Short course regimen has become the major trend in the field of adjuvant radiotherapy for patients with breast cancer. Hypofractionated radiotherapy (HF-RT) regimen of 40\u201342.5\u2009Gy in 15\u201316 fractions has been established as a preferred option for whole breast irradiation. However, few evidences of hypofractionated regional nodal irradiation (RNI), especially involving internal mammary nodes (IMNs), could be available during the era of intensity-modulated radiation therapy (IMRT). Against this background, we design this trial to explore the hypothesis that HF-RT regimen involving RNI (including infraclavicular, supraclavicular nodes and IMNs) will be non-inferior to a standard schedule by using IMRT technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This is an open-label randomised, non-inferior, multicentre phase III trial. Patients with breast cancer with an indication for RNI after breast conserving surgery or mastectomy are randomised at a ratio of 1:1 into the following two groups: hypofractionated regimen of 2.67\u2009Gy for 16 fractions or conventional regimen of 2\u2009Gy for 25 fractions. The dose was prescribed to ipsilateral chest wall or whole breast and RNI (including infraclavicular, supraclavicular nodes and IMNs, lower axilla if indicated). The trial plans to enrol a total of 801 patients and all patients will be treated using IMRT technique. The primary endpoint is 5-year locoregional recurrence. The secondary endpoints include 5-year distant metastasis free survival, invasive recurrence-free survival, overall survival, accumulative acute radiation-induced toxicity and accumulative late radiation-induced toxicity, cosmetic outcomes and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study has been approved by the Ethical Committee of Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine (version 2018-95-3) and approvals from ethical committee of each participating centre have also been obtained. Research findings will be submitted for publication in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\" xlink:href=\"NCT03829553\">NCT03829553<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-062034","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T12:53:16Z","timestamp":1662036796000},"page":"e062034","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Hypofractionated versus conventional intensity-modulated radiation irradiation (HARVEST-adjuvant): study protocol for a randomised non-inferior multicentre phase III trial"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct03829553","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-7367","authenticated-orcid":false,"given":"Jinrong","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Yat-Sen Breast Tumor Hospital, Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University, Guangzhou, Guangdong, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Tenth People's Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, Ruijin Hospital, Shanghai Jiaotong university School of Medicine, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Comprehensive Breast Health Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Xiang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Huang","sequence":"additional","affiliation":[{"name":"Yat-Sen Breast Tumor Hospital, Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University, Guangzhou, Guangdong, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China"},{"name":"Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"2025121402425480000_12.9.e062034.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025121402425480000_12.9.e062034.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415369"},{"key":"2025121402425480000_12.9.e062034.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415340"},{"key":"2025121402425480000_12.9.e062034.4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.6456"},{"key":"2025121402425480000_12.9.e062034.5","first-page":"2127","article-title":"Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials","volume":"383","author":"McGale","year":"2014"},{"key":"2025121402425480000_12.9.e062034.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2"},{"key":"2025121402425480000_12.9.e062034.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66544-0"},{"key":"2025121402425480000_12.9.e062034.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.01.005"},{"key":"2025121402425480000_12.9.e062034.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70386-3"},{"key":"2025121402425480000_12.9.e062034.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70077-9"},{"key":"2025121402425480000_12.9.e062034.11","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(08)60348-7","article-title":"The UK standardisation of breast radiotherapy (start) trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial","volume":"371","author":"group","year":"2008","journal-title":"The Lancet"},{"key":"2025121402425480000_12.9.e062034.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906260"},{"key":"2025121402425480000_12.9.e062034.13","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1200\/JCO.20.01024","article-title":"Hypofractionated versus conventional fractionated radiotherapy after breast-conserving surgery in the modern treatment era: a multicenter, randomized controlled trial from China","volume":"38","author":"Wang","year":"2020","journal-title":"J Clin Oncol"},{"key":"2025121402425480000_12.9.e062034.14","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4118-7"},{"key":"2025121402425480000_12.9.e062034.15","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0060"},{"key":"2025121402425480000_12.9.e062034.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2018.01.012"},{"key":"2025121402425480000_12.9.e062034.17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz173"},{"key":"2025121402425480000_12.9.e062034.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30932-6"},{"key":"2025121402425480000_12.9.e062034.19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.radonc.2020.07.038","article-title":"Variation in the use of radiotherapy fractionation for breast cancer: survival outcome and cost implications","volume":"152","author":"Batumalai","year":"2020","journal-title":"Radiother Oncol"},{"key":"2025121402425480000_12.9.e062034.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.16616"},{"key":"2025121402425480000_12.9.e062034.21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijrobp.2016.10.002","article-title":"Nation-Scale adoption of shorter breast radiation therapy schedules can increase survival in resource constrained economies: results from a Markov chain analysis","volume":"97","author":"Khan","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025121402425480000_12.9.e062034.22","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djx068","article-title":"Cost-Effectiveness analysis comparing conventional, Hypofractionated, and intraoperative radiotherapy for early-stage breast cancer","volume":"109","author":"Deshmukh","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"2025121402425480000_12.9.e062034.23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ijrobp.2017.12.015","article-title":"A Phase 2 Study of 2\u00a0Weeks of Adjuvant Whole Breast\/Chest Wall and\/or Regional Nodal Radiation Therapy for Patients With Breast Cancer","volume":"100","author":"Yadav","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025121402425480000_12.9.e062034.24","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30813-1"},{"key":"2025121402425480000_12.9.e062034.25","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ijrobp.2020.03.020","article-title":"5-Year update of a Multi-Institution, prospective phase 2 Hypofractionated postmastectomy radiation therapy trial","volume":"107","author":"Poppe","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025121402425480000_12.9.e062034.26","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1200\/JCO.2016.70.7158","article-title":"Hypofractionated postmastectomy radiation therapy is safe and effective: first results from a prospective phase II trial","volume":"35","author":"Khan","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025121402425480000_12.9.e062034.27","doi-asserted-by":"crossref","unstructured":"Dodwell CT D , McGale P , Coles C . Regional lymph node irradiation in early stage breast cancer: an EBCTCG meta-analysis of 13,000 women in 14 trials. In: San Antonio Breast Cancer Symposium ; December 4-8, 2018. San Antonio, Texas: American Association for Cancer Research, 2020: GS4\u201302.","DOI":"10.1158\/1538-7445.SABCS18-GS4-02"},{"key":"2025121402425480000_12.9.e062034.28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1748-717X-8-81","article-title":"Post mastectomy linac IMRT irradiation of chest wall and regional nodes: dosimetry data and acute toxicities","volume":"8","author":"Ma","year":"2013","journal-title":"Radiat Oncol"},{"key":"2025121402425480000_12.9.e062034.29","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0299"},{"key":"2025121402425480000_12.9.e062034.30","unstructured":"Group. RTO . Breast cancer atlas for radiation therapy planning: consensus definitions. 2013."},{"key":"2025121402425480000_12.9.e062034.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.10.058"},{"key":"2025121402425480000_12.9.e062034.32","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0016"},{"key":"2025121402425480000_12.9.e062034.33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.7552"},{"key":"2025121402425480000_12.9.e062034.34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.90"},{"key":"2025121402425480000_12.9.e062034.35","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70460-7"},{"key":"2025121402425480000_12.9.e062034.36","doi-asserted-by":"crossref","unstructured":"Rutgers MD EJ , Poncet C , Straver ME , et al . Abstract GS4-01: radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer patients: 10 year follow up results of the EORTC AMAROS trial (EORTC 10981\/22023). San Antonio Breast Cancer Symposium; December 6; San Antonio, TX 2018.","DOI":"10.1158\/1538-7445.SABCS18-GS4-01"},{"key":"2025121402425480000_12.9.e062034.37","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1200\/JCO.20.00459","article-title":"Quantifying the impact of axillary surgery and nodal irradiation on breast Cancer\u2013Related lymphedema and local tumor control: long-term results from a prospective screening trial","volume":"38","author":"Naoum","year":"2020","journal-title":"Journal of Clinical Oncology"},{"key":"2025121402425480000_12.9.e062034.38","doi-asserted-by":"crossref","first-page":"e742","DOI":"10.1016\/S1470-2045(17)30617-4","article-title":"Radiotherapy in the setting of breast reconstruction: types, techniques, and timing","volume":"18","author":"AY","year":"2017","journal-title":"The Lancet Oncology"},{"key":"2025121402425480000_12.9.e062034.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.09.023"},{"key":"2025121402425480000_12.9.e062034.40","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.5.532"},{"key":"2025121402425480000_12.9.e062034.41","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.bjps.2017.05.057","article-title":"Determining the outcomes of post-mastectomy radiation therapy delivered to the definitive implant in patients undergoing one- and two-stage implant-based breast reconstruction: A\u00a0systematic review and meta-analysis","volume":"70","author":"Magill","year":"2017","journal-title":"Journal of Plastic, Reconstructive & Aesthetic Surgery"},{"key":"2025121402425480000_12.9.e062034.42","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s00432-019-02938-8","article-title":"HALFMOON tomotherapy (helical altered fractionation for iMplant partial omission): iMplant-sparing post-mastectomy radiotherapy reshaping the clinical target volume in the reconstructed breast","volume":"145","author":"Leonardi","year":"2019","journal-title":"J Cancer Res Clin Oncol"},{"key":"2025121402425480000_12.9.e062034.43","doi-asserted-by":"crossref","first-page":"S492","DOI":"10.1016\/S0167-8140(18)31228-3","article-title":"PO-0918: consensus on target volume delineation and treatment planning strategy for the DBCG RT RECON trial","volume":"127","author":"Nissen","year":"2018","journal-title":"Radiotherapy and Oncology"},{"key":"2025121402425480000_12.9.e062034.44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.radonc.2019.04.010","article-title":"ESTRO ACROP consensus guideline for target volume delineation in the setting of postmastectomy radiation therapy after implant-based immediate reconstruction for early stage breast cancer","volume":"137","author":"Kaidar-Person","year":"2019","journal-title":"Radiotherapy and Oncology"},{"key":"2025121402425480000_12.9.e062034.45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.clon.2020.09.004","article-title":"Postmastectomy radiation therapy planning after immediate implant-based reconstruction using the European Society for radiotherapy and Oncology-Advisory Committee in radiation oncology practice consensus guidelines for target volume delineation","volume":"33","author":"Kaidar-Person","year":"2021","journal-title":"Clin Oncol"},{"key":"2025121402425480000_12.9.e062034.46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.breast.2020.11.020","article-title":"Hypofractionated versus conventional fractionated radiotherapy for breast cancer in patients with reconstructed breast: toxicity analysis","volume":"55","author":"Kim","year":"2021","journal-title":"The Breast"},{"key":"2025121402425480000_12.9.e062034.47","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.577136","article-title":"Hypofractionated radiotherapy with volumetric modulated Arc therapy decreases postoperative complications in prosthetic breast reconstructions: a clinicopathologic study","volume":"10","author":"Song","year":"2020","journal-title":"Front Oncol"},{"key":"2025121402425480000_12.9.e062034.48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1748-717X-8-81","article-title":"Post mastectomy linac IMRT irradiation of chest wall and regional nodes: dosimetry data and acute toxicities","volume":"8","author":"Ma","year":"2013","journal-title":"Radiation Oncology"},{"key":"2025121402425480000_12.9.e062034.49","first-page":"1048","article-title":"Dosimetric study of cardioulmonary volume dose of internal mammary node irradiation under inverse-planned intensity-modulated radiation therapy","volume":"29","author":"Wu","year":"2020","journal-title":"Chin J Radial Oncol"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2022-062034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:43:06Z","timestamp":1765708986000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2022-062034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,1]]},"published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1136\/bmjopen-2022-062034"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2022-062034","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}