{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:02:16Z","timestamp":1765605736390,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","award":["AUFF-E-2020-7-20"],"award-info":[{"award-number":["AUFF-E-2020-7-20"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,6,9]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Since disseminated intravascular coagulation (DIC) was first described, it has been considered a serious disease of the coagulation system and a major challenge to clinicians. Currently, several important knowledge gaps remain. The DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study will aim to answer questions regarding the incidence and mortality of patients with DIC including time trends. The study will also identify prognostic factors that may guide personalised prevention and treatment. Furthermore, the study will describe treatment patterns and the safety and effectiveness of various treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will establish the DANDIC Cohort using data collected in daily clinical practice from the Central Denmark Region, which covers approximately 1.3\u2009million residents. The study period will encompass 1 January 2011 through 1 July 2021. Potential DIC cases will be identified from the hospital laboratory database, based on coagulation biomarkers, and diagnoses will be adjudicated by medical experts. The dataset will be enriched with detailed clinical data from electronic medical charts on aetiologies, bleeding, microthrombus formation, organ failure, thrombosis, treatments and comorbidities. The dataset will also take advantage of in-hospital data with longitudinal information on laboratory records, transfusions, microbiology and treatments. It will be possible to merge this dataset with other unique Danish health registries with more than 10 years of virtually complete follow-up. The project will use state-of-the-art epidemiological and biostatistical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The project has been approved by the Danish Patient Safety Authority (31-1521-452), the Central Denmark Region (1-45-70-83-21), the Danish Data Protection Agency (1-16-02-258-21) and all the hospital chairs. Register-based studies require no ethical approval in Denmark. The results will be disseminated in international peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-062623","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T11:00:30Z","timestamp":1657796430000},"page":"e062623","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the epidemiology of disseminated intravascular coagulation: protocol for the DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-336X","authenticated-orcid":false,"given":"Simon","family":"Fl\u00e6ng","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asger","family":"Granfeldt","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jecko","family":"Thachil","sequence":"additional","affiliation":[{"name":"Department of Haematology, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-7252","authenticated-orcid":false,"given":"Kasper","family":"Adelborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Biochemistry, Regional Hospital G\u00f8dstrup, Herning, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"2025121221571825000_12.7.e062623.1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/bjh.17172","article-title":"Disseminated intravascular coagulation: epidemiology, biomarkers, and management","volume":"192","author":"Adelborg","year":"2021","journal-title":"Br J Haematol"},{"key":"2025121221571825000_12.7.e062623.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000147769.07699.E3"},{"key":"2025121221571825000_12.7.e062623.3","first-page":"73","article-title":"Clinical aspects of DIC--disseminated intravascular coagulation","volume":"48","author":"Matsuda","year":"1996","journal-title":"Pol J Pharmacol"},{"key":"2025121221571825000_12.7.e062623.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2112"},{"key":"2025121221571825000_12.7.e062623.5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/1471-0528.16938","article-title":"Effect of antithrombin III among patients with disseminated intravascular coagulation in obstetrics: a nationwide observational study in Japan","volume":"129","author":"Iwasaki","year":"2022","journal-title":"BJOG"},{"key":"2025121221571825000_12.7.e062623.6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52968-y","article-title":"Effect of high-dose antithrombin supplementation in patients with septic shock and disseminated intravascular coagulation","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"key":"2025121221571825000_12.7.e062623.7","doi-asserted-by":"crossref","first-page":"180243","DOI":"10.1038\/sdata.2018.243","article-title":"Nationwide registry of sepsis patients in Japan focused on disseminated intravascular coagulation 2011-2013","volume":"5","author":"Hayakawa","year":"2018","journal-title":"Sci Data"},{"key":"2025121221571825000_12.7.e062623.8","unstructured":"International prospective registry of disseminated intravascular coagulation: ClinicalTrials.gov, 2018. Available: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03577015"},{"key":"2025121221571825000_12.7.e062623.9","unstructured":"Two SSC Subcommittees launch global registry of DIC in pregnancy: International Society on thrombosis and haemostasis, 2018. Available: https:\/\/www.isth.org\/news\/398948\/Two-SSC-Subcommittees-Launch-Global-Registry-of-DIC-in-Pregnancy.htm"},{"key":"2025121221571825000_12.7.e062623.10","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S179083"},{"key":"2025121221571825000_12.7.e062623.11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140197","article-title":"Comparison of the Five Danish Regions Regarding Demographic Characteristics, Healthcare Utilization, and Medication Use--A Descriptive Cross-Sectional Study","volume":"10","author":"Henriksen","year":"2015","journal-title":"PLoS One"},{"key":"2025121221571825000_12.7.e062623.12","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"2025121221571825000_12.7.e062623.13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-016-1468-1","article-title":"Revision of the Japanese association for acute medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity","volume":"20","author":"Iba","year":"2016","journal-title":"Crit Care"},{"key":"2025121221571825000_12.7.e062623.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00955.x"},{"key":"2025121221571825000_12.7.e062623.15","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000202209.42491.38"},{"key":"2025121221571825000_12.7.e062623.16","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S245060"},{"key":"2025121221571825000_12.7.e062623.17","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/17474086.2016.1203250","article-title":"Disseminated intravascular coagulation - new pathophysiological concepts and impact on management","volume":"9","author":"Thachil","year":"2016","journal-title":"Expert Rev Hematol"},{"key":"2025121221571825000_12.7.e062623.18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/jth.15572","article-title":"Vaccine-Induced immune thrombotic thrombocytopenia (VITT): update on diagnosis and management considering different resources","volume":"20","author":"Greinacher","year":"2022","journal-title":"J Thromb Haemost"},{"key":"2025121221571825000_12.7.e062623.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.09.002"},{"key":"2025121221571825000_12.7.e062623.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.09.004"},{"key":"2025121221571825000_12.7.e062623.21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"2025121221571825000_12.7.e062623.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"2025121221571825000_12.7.e062623.23","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1589"},{"key":"2025121221571825000_12.7.e062623.24","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"2025121221571825000_12.7.e062623.25","unstructured":"Rothman KJ . Modern epidemiology. Wolters Kluwer, 2021."},{"key":"2025121221571825000_12.7.e062623.26","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12636","article-title":"Disseminated intravascular coagulation diagnosis: positive predictive value of the ISTH score in a Danish population","volume":"5","author":"Larsen","year":"2021","journal-title":"Res Pract Thromb Haemost"},{"key":"2025121221571825000_12.7.e062623.27","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr213"},{"key":"2025121221571825000_12.7.e062623.28","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012832"},{"key":"2025121221571825000_12.7.e062623.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012817"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2022-062623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:57:27Z","timestamp":1765605447000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2022-062623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,14]]},"published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1136\/bmjopen-2022-062623"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2022-062623","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}